Pep19-2.5
Based on 1 publication(s) in Google Scholar
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis.
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- Pureza: 98.98%
- No. CAS: 1322711-38-5
- Fòrmula: C135H187N37O22S
- Peso molecular:2712.23
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pep19-2.5
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Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sepsis model in male New Zealand rabbits (2-2.5 kg)[2]
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Dosage:5 mg/kg, combinded with 15 mg/kg Ceftriaxone; total volume of 2 mL
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Administration:Intravenous injection; extracted blood from the marginal ear vein at different time points post challenge (0, 2, 30, 90 and 180 min)
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Result:Killed bacteria and eliminates bacteremia 30 min post challenge;
Inhibited Toll-like receptor 4 agonists in serum 90 min post challenge;
Reduced serum levels of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor α);
And reverted to hypothermia and gives rise to temperature values indistinguishable from basal levels 330 min post challenge.
Chemical Information
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No. CAS 1322711-38-5
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Appearance Solid
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Peso molecular 2712.23
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Fòrmula C135H187N37O22S
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Color White to off-white
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Sequence Shortening
GCKKYRRFRWKFKGKFWFWG
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Behav Brain Res
Serotonin mitigates depression in a rotenone-induced mouse Parkinson's disease model by inhibiting hippocampal neuronal pyroptosis and neuroinflammation. [Abstract]2025 Jul 26:490:115620. PMID: 40345554
Pureza y Documentación
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Ficha de datos (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Heinbockel L, et al. Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5. Front Immunol. 2018 Jul 26;9:1704. [Content Brief]
[2]. Bárcena-Varela S, et al. Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits. Exp Mol Med. 2017 Jun 16;49(6):e345. [Content Brief]
[3]. Jannadi H, et al. Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation. Microb Pathog. 2019 Aug;133:103546. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pep19-2.5 Related Classifications
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