2. GPCR/G Protein Neuronal Signaling PI3K/Akt/mTOR Apoptosis
  3. Dopamine Receptor PI3K Apoptosis
  4. Flupentixol dihydrochloride

Flupentixol (dihydrochloride)  (Synonyms: Flupenthixol (dihydrochloride); フルペンチキソール 二塩酸塩)

製品番号: HY-15856B 純度: 98.52%
COA 取扱説明書 Technical Support

Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research.

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Flupentixol dihydrochloride

Flupentixol (dihydrochloride) 構造式

CAS 番号 : 2413-38-9

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 56 在庫あり
Solution
10 mM * 1 mL in DMSO USD 56 在庫あり
Solid
5 mg $50 在庫あり
10 mg $70 在庫あり
25 mg $110 在庫あり
50 mg $150 在庫あり
100 mg $190 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

Other Forms of Flupentixol dihydrochloride:

Flupentixol (dihydrochloride) 関連抗体

Top Publications Citing Use of Products

Dopamine Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

PI3K アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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製品説明

Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research[1][2][3].

IC50 & Target[3]

PI3Kα

127 nM (IC50)

D1 Receptor

 

D2 Receptor

 

体外実験

Flupentixol (2.5-40 μM; 72 h) treatment inhibits the viability of lung cancer cells in a dose-dependent manner[3].
Flupentixol (2.5-40 μM; 24 h) induces apoptosis in lung cancer cells[3].
Flupentixol (2.5-15 μM; 24 h) inhibits p-AKT and Bcl-2 expression levels[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flupentixol (dihydrochloride) 関連抗体

Cell Viability Assay[3]

Cell Line: A549, H661, SK-SEM-1, and NCAL-H520 cells
Concentration: 2.5, 5, 10, 20, or 40 μM
Incubation Time: 72 hours
Result: Showed the IC50s of 5.708 μM and 6.374 μM for A549 and H661 cells, respectively.

Apoptosis Analysis[3]

Cell Line: A549 and H661 cells
Concentration: 5, 10, 20 and 40 μM
Incubation Time: 24 hours
Result: Increased the percentage of cells in early apoptosis compared with the negative control in both A549 and H661 (p<0.05).
Induced the cleavage of PARP and caspase-3 in a dose-dependent manner.

Western Blot Analysis[3]

Cell Line: A549 and H661 cells
Concentration: 2.5, 5, 10, and 15 μM
Incubation Time: 24 hours
Result: Decreased AKT phosphorylation levels in a dose-dependent manner, decreased the expression levels of Bcl-2.
体内実験

Flupentixol (intragastric injection; 40 mg/kg; once daily; 21 d) suppresses A549 xenografted tumor growth in nude mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C nude mice injected with A549 cells[3]
Dosage: 40 mg/kg
Administration: Intragastric injection; 40 mg/kg; once daily; 21 days
Result: Reduced tumor volumes compared to the vehicle control (p<0.05), reduced tumor weights by 64.1% (p<0.05).
分子量

507.44

分子式

C23H27Cl2F3N2OS
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OCCN1CCN(CC/C=C2C3=C(SC4=C/2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (197.07 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (65.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9707 mL 9.8534 mL 19.7068 mL
5 mM 0.3941 mL 1.9707 mL 3.9414 mL
10 mM 0.1971 mL 0.9853 mL 1.9707 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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C2

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.93 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.93 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (98.53 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.73%

COA (246 KB) HNMR (214 KB) LCMS (337 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.9707 mL 9.8534 mL 19.7068 mL 49.2669 mL
5 mM 0.3941 mL 1.9707 mL 3.9414 mL 9.8534 mL
10 mM 0.1971 mL 0.9853 mL 1.9707 mL 4.9267 mL
15 mM 0.1314 mL 0.6569 mL 1.3138 mL 3.2845 mL
20 mM 0.0985 mL 0.4927 mL 0.9853 mL 2.4633 mL
25 mM 0.0788 mL 0.3941 mL 0.7883 mL 1.9707 mL
30 mM 0.0657 mL 0.3284 mL 0.6569 mL 1.6422 mL
40 mM 0.0493 mL 0.2463 mL 0.4927 mL 1.2317 mL
50 mM 0.0394 mL 0.1971 mL 0.3941 mL 0.9853 mL
60 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8211 mL
H2O 80 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
100 mM 0.0197 mL 0.0985 mL 0.1971 mL 0.4927 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Flupentixol dihydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flupentixol2413-38-9FlupenthixolDopamine ReceptorPI3KApoptosisPhosphoinositide 3-kinaseanti-proliferative activityinduce apoptosisschizophreniaanxiolyticdepressiveA549H661SK-SEM-1NCAL-H520Inhibitorinhibitorinhibit

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