2. Apoptosis Epigenetics Cell Cycle/DNA Damage NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. PARP DNA/RNA Synthesis Reactive Oxygen Species (ROS) Caspase Apoptosis Mitochondrial Metabolism
  4. Aniline mustard

Aniline mustard  (Synonyms: N,N-Bis(2-chloroethyl)aniline)

製品番号: HY-121713 純度: 99.72%
COA 取扱説明書 Technical Support

Aniline mustard (N, n-BIS (2-chloroethyl) aniline) is an anticancer agent.

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Aniline mustard

Aniline mustard 構造式

CAS 番号 : 553-27-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
5 g $25 在庫あり
10 g $40 在庫あり
25 g $85 在庫あり
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Aniline mustard 関連抗体

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製品説明

Aniline mustard (N, n-BIS (2-chloroethyl) aniline) is an anticancer agent[1].

Cellular Effect
Cell Line Type Value Description References
CHO-AA8 IC50
10.5 μM
Compound: 1
Evaluated for cytotoxicity under aerobic conditions against AA8 cells using microassay
Evaluated for cytotoxicity under aerobic conditions against AA8 cells using microassay
[PMID: 2296009]
UV4 IC50
0.33 μM
Compound: 1
Evaluated for cytotoxicity under aerobic conditions against UV4 cells using microassay
Evaluated for cytotoxicity under aerobic conditions against UV4 cells using microassay
[PMID: 2296009]
分子量

218.13

分子式

C10H13Cl2N
CAS 番号
Appearance

Solid

Color

Off-white to pale purple

SMILES

ClCCN(C1=CC=CC=C1)CCCl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (458.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5845 mL 22.9224 mL 45.8449 mL
5 mM 0.9169 mL 4.5845 mL 9.1690 mL
10 mM 0.4584 mL 2.2922 mL 4.5845 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.46 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (11.46 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.72%

COA (246 KB) HNMR (129 KB) MS (154 KB) GC (231 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5845 mL 22.9224 mL 45.8449 mL 114.6121 mL
5 mM 0.9169 mL 4.5845 mL 9.1690 mL 22.9224 mL
10 mM 0.4584 mL 2.2922 mL 4.5845 mL 11.4612 mL
15 mM 0.3056 mL 1.5282 mL 3.0563 mL 7.6408 mL
20 mM 0.2292 mL 1.1461 mL 2.2922 mL 5.7306 mL
25 mM 0.1834 mL 0.9169 mL 1.8338 mL 4.5845 mL
30 mM 0.1528 mL 0.7641 mL 1.5282 mL 3.8204 mL
40 mM 0.1146 mL 0.5731 mL 1.1461 mL 2.8653 mL
50 mM 0.0917 mL 0.4584 mL 0.9169 mL 2.2922 mL
60 mM 0.0764 mL 0.3820 mL 0.7641 mL 1.9102 mL
80 mM 0.0573 mL 0.2865 mL 0.5731 mL 1.4327 mL
100 mM 0.0458 mL 0.2292 mL 0.4584 mL 1.1461 mL
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Aniline mustard Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aniline mustard553-27-5N,N-Bis(2-chloroethyl)anilinePARPDNA/RNA SynthesisReactive Oxygen Species (ROS)CaspaseApoptosisMitochondrial Metabolismpoly ADP ribose polymerase anticancerInhibitorinhibitorinhibit

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