553-27-5
553-27-5
Chemical Structure
Aniline mustard
Synonym(s): N,N-Bis(2-chloroethyl)aniline
- CAS. Nr.: 553-27-5
- Formula:C10H13Cl2N
- Molecular Weight:218.13
IUPAC Name: N,N-bis(2-chloroethyl)aniline
InChIKey: ROSJKFFLIXTTAW-UHFFFAOYSA-N
SMILES: ClCCN(C1=CC=CC=C1)CCCl
Biological Activity: Aniline mustard (N,N-Bis(2-chloroethyl)aniline) is a DNA cross-linking agent. Aniline mustard can be released from quinone-based prodrugs after NQO1-mediated reduction. Aniline mustard exhibits antitumor activity in mice. Aniline mustard can be used for research on tumors[1][2][3][4].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Aniline mustard | 99.72% | Aniline mustard (N,N-Bis(2-chloroethyl)aniline) is a DNA cross-linking agent. Aniline mustard can be released from quinone-based prodrugs after NQO1-mediated reduction. Aniline mustard exhibits antitumor activity in mice. Aniline mustard can be used for research on tumors. | ||||||||||||||||||||
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References
- [1]. Niculescu-Duvaz D, et al. Self-immolative nitrogen mustard prodrugs for suicide gene therapy. Journal of medicinal chemistry. 1998 Dec 17;41(26):5297-309.
- [2]. Volpato M, et al. Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system. Molecular cancer therapeutics. 2007 Dec;6(12 Pt 1):3122-30.
- [3]. Dorough HW. Biological activity of pesticide conjugates.
- [4]. Ponnamperumage TNF, et al. Tumor-Selective and Chemical Activation Strategies for Nitrogen Mustard Prodrugs. Chemistry (Weinheim an der Bergstrasse, Germany). 2026 Apr 01;32(13):e03344.
