2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. 4-Diethylaminobenzaldehyde

4-Diethylaminobenzaldehyde 

Cat. No.: HY-W016645 Purity: 98.82%
COA Handling Instructions

4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM).

For research use only. We do not sell to patients.

4-Diethylaminobenzaldehyde Chemical Structure

4-Diethylaminobenzaldehyde Chemical Structure

CAS No. : 120-21-8

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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
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ready for reconstitution
 USD 61 In-stock
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Solid
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Based on 1 publication(s) in Google Scholar

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Description

4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM)[1][2].

In Vitro

4-Diethylaminobenzaldehyde (DEAB) is reversible competitive inhibitor of ALDH1 (competitive with the aldehyde substrate) with a Ki value of 4 nM, and irreversibly inactivates ALDH7A1 via formation of a stable, covalent acyl-enzyme species[1].
The Temozolomide (TMZ)-resistant cell line LN18 is treated with a combination of TMZ and 4-Diethylaminobenzaldehyde for 10 days. As indicated by colony formation assay, the clonogenic capacity of LN18 cells exposed to TMZ in combination with 4-Diethylaminobenzaldehyde (DEAB) is significantly attenuated[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

177.24

Appearance

Solid

Formula

C11H15NO
CAS No.
SMILES

O=CC1=CC=C(N(CC)CC)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (564.21 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6421 mL 28.2103 mL 56.4207 mL
5 mM 1.1284 mL 5.6421 mL 11.2841 mL
10 mM 0.5642 mL 2.8210 mL 5.6421 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.25 mg/mL (18.34 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.82%

COA (248 KB) HNMR (95 KB) LCMS (113 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

4-Diethylaminobenzaldehyde120-21-8Aldehyde Dehydrogenase (ALDH)irreversibleglioblastomaanti-androgeniccompetitiveALDH1Inhibitorinhibitorinhibit

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4-Diethylaminobenzaldehyde
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