Creatine monohydrate

Name: Creatine monohydrate
Brand: MedChemExpress
SKU: HY-W017462
Rating: 5.0 (5 reviews)

製品番号: HY-W017462 純度: 99.98%: Data Sheet SDS COA 取扱説明書
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Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 6020-87-7

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 27	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 27	在庫あり	Estimated Time of Arrival: December 31
Solid
100 mg	$25	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 5 publication(s) in Google Scholar

Other Forms of Creatine monohydrate:

Creatine-d₅ monohydrate 在庫あり
Creatine 在庫あり
Creatine-¹³C monohydrate お問い合わせ
Creatine monohydrate (Standard) お問い合わせ

顧客検証

Bio/Physico-chemical Assay

ELISA

Flow Cytometry

In Vivo Efficacy Study

: Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2426135122. [Abstract]; SPR analysis showed Creatine (25 μM) binding to hCRT, with a dissociation constant (K_D) of 3.2 μM.

: Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]; Creatine (10, 100, and 1,000 µmol/L; 24 h) stimulates type I IFN induction via the cGAMP–cGAS–STING–IRF3 signaling axis. 2030-cGAMP was robustly induced in monocytes following Creatine treatment.

: Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]; Examination of cGAS-STING downstream signaling in monocytes by flow cytometry revealed activation of the STING-TBK1-IRF3 signaling axis following Creatine (10, 100, and 1,000 µmol/L; 24 h) treatment.

: Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]; Combination of LNP-Gsdme and Creatine (10.5 mg/mice; once daily; IT) synergistically suppresses tumor growth. Tumor growth curves, tumor images, and tumor weights of B16F10 and 4T1 tumor–bearing mice treated with LNP-Gsdme/GFP or combined with Creatine.

: Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139. [Abstract]; The syngeneic mouse MC38 CRC model was utilized to examine how Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) supplementation, with or without the addition of anti-PD-1 antibody, affected tumor growth and survival. Tumor growth, tumor weights, and survival curves were recorded for the MC38 model mice given the different therapies. Combination therapy significantly suppressed tumor growth and prolonged survival of MC38 tumor-bearing immunocompetent C57BL/6 J mice compared to either single-agent or control-treated groups.

: Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139. [Abstract]; Tumor growth curve and tumor weights of DLD1 xenografts after indicated treatment.To ascertain whether Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) exhibits an inhibitory effect on tumor progression, a DLD-1 xenograft model was established, and Creatine was found to remarkably inhibit tumor development.

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

PI3K アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

Akt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Akt Akt1 Akt2 Akt3

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain^[1].

IC₅₀ & Target

Human Endogenous Metabolite

Microbial Metabolite

体外実験

Creatine monohydrate (10-20 mM, 1-3 weeks) promotes the cell growth, differentiation and mineralization of osteoblast-like cells^[2].
Creatine monohydrate (0.1-10 mM, 2-24 h) scanvages the free radicals, protects the DNA especially mtDNA from oxidative damage^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Creatine monohydrate (0.1-1000 mg/kg, po, single dose) exhibits antidepressant-like activity in mouse tail suspension test, which could be enhanced by dopamine receptor agonist SKF38393 (HY-12520A) and Apomorphine (HY-12723)^[4].
Creatine monohydrate (0.03-0.3 mg/kg, drinking water for 8 weeks) stimulates the PI3K/AKT signaling pathways, promotes the protein synthesis and muscle hypertrophy, thereby promoting the performance of short-duration, high-intensity exercise in rats models^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats models^[5]
Dosage:	0.03-0.3 mg/kg
Administration:	drinking water for 8 weeks
Result:	Increased the perimeter and area of the soleus muscle.

臨床実験

分子量

149.15

分子式

C₄H₁₁N₃O₃

CAS 番号

6020-87-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CN(C(N)=N)C.[H]O[H]

Structure Classification

Amino acids

Initial Source

Endogenous metabolite

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 16.67 mg/mL (111.77 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7047 mL	33.5233 mL	67.0466 mL
5 mM	1.3409 mL	6.7047 mL	13.4093 mL
10 mM	0.6705 mL	3.3523 mL	6.7047 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.98%

Select Batch:

データシート (274 KB) SDS (393 KB)

COA (245 KB) HNMR (228 KB) RP-HPLC (206 KB) LCMS (95 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Nouioua S, et al. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency. Neuromuscul Disord. 2013 Aug;23(8):670-4. [Content Brief]

[2]. Gerber I, et al., Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. Eur Cell Mater. 2005 Jul 15;10:8-22. [Content Brief]

[3]. Guidi C, et al., Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA. Biochim Biophys Acta. 2008 Jan;1780(1):16-26. [Content Brief]

[4]. Cunha MP, et al., Antidepressant-like effect of creatine in mice involves dopaminergic activation. J Psychopharmacol. 2012 Nov;26(11):1489-501. [Content Brief]

[5]. ARRUDA I F S, et al. Histological effects of Creatine monohydrate supplementation on muscle tissue in Wistar rats[J]. Modern Medicine, 2023, 30(2).

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.7047 mL	33.5233 mL	67.0466 mL	167.6165 mL
	5 mM	1.3409 mL	6.7047 mL	13.4093 mL	33.5233 mL
	10 mM	0.6705 mL	3.3523 mL	6.7047 mL	16.7617 mL
	15 mM	0.4470 mL	2.2349 mL	4.4698 mL	11.1744 mL
	20 mM	0.3352 mL	1.6762 mL	3.3523 mL	8.3808 mL
	25 mM	0.2682 mL	1.3409 mL	2.6819 mL	6.7047 mL
	30 mM	0.2235 mL	1.1174 mL	2.2349 mL	5.5872 mL
	40 mM	0.1676 mL	0.8381 mL	1.6762 mL	4.1904 mL
	50 mM	0.1341 mL	0.6705 mL	1.3409 mL	3.3523 mL
	60 mM	0.1117 mL	0.5587 mL	1.1174 mL	2.7936 mL
	80 mM	0.0838 mL	0.4190 mL	0.8381 mL	2.0952 mL
	100 mM	0.0670 mL	0.3352 mL	0.6705 mL	1.6762 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.