2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Endogenous Metabolite Dopamine Receptor
  4. Creatine

Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

For research use only. We do not sell to patients.

CAS No. : 57-00-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
500 mg In-stock
5 g In-stock
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50 g   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Creatine:

Creatine Related Antibodies

Top Publications Citing Use of Products

    Creatine purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2426135122.  [Abstract]

    SPR analysis showed Creatine (25 μM) binding to hCRT, with a dissociation constant (KD) of 3.2 μM.

    Creatine purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956.  [Abstract]

    Creatine (10, 100, and 1,000 µmol/L; 24 h) stimulates type I IFN induction via the cGAMP–cGAS–STING–IRF3 signaling axis. 2030-cGAMP was robustly induced in monocytes following Creatine treatment.

    Creatine purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956.  [Abstract]

    Examination of cGAS-STING downstream signaling in monocytes by flow cytometry revealed activation of the STING-TBK1-IRF3 signaling axis following Creatine (10, 100, and 1,000 µmol/L; 24 h) treatment.

    Creatine purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956.  [Abstract]

    Combination of LNP-Gsdme and Creatine (10.5 mg/mice; once daily; IT) synergistically suppresses tumor growth. Tumor growth curves, tumor images, and tumor weights of B16F10 and 4T1 tumor–bearing mice treated with LNP-Gsdme/GFP or combined with Creatine.

    Creatine purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139.  [Abstract]

    The syngeneic mouse MC38 CRC model was utilized to examine how Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) supplementation, with or without the addition of anti-PD-1 antibody, affected tumor growth and survival. Tumor growth, tumor weights, and survival curves were recorded for the MC38 model mice given the different therapies. Combination therapy significantly suppressed tumor growth and prolonged survival of MC38 tumor-bearing immunocompetent C57BL/6 J mice compared to either single-agent or control-treated groups.

    Creatine purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139.  [Abstract]

    Tumor growth curve and tumor weights of DLD1 xenografts after indicated treatment.To ascertain whether Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) exhibits an inhibitory effect on tumor progression, a DLD-1 xenograft model was established, and Creatine was found to remarkably inhibit tumor development.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 EC50
    5 μM
    Compound: 586
    Substrate uptake by the Sodium- and Chloride-Dependent Creatine Transporter 1 (CRTR, SLC6A8) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A8 cells (PubChem AID: 1794823)
    Substrate uptake by the Sodium- and Chloride-Dependent Creatine Transporter 1 (CRTR, SLC6A8) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A8 cells (PubChem AID: 1794823)
    		10.5281/zenodo.7360539
    In Vitro

    Creatine (10-20 mM, 1-3 weeks) promotes the cell growth, differentiation and mineralization of osteoblast-like cells[2].
    Creatine (0.1-10 mM, 2-24 h) scanvages the free radicals, protects the DNA especially mtDNA from oxidative damage[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Creatine Related Antibodies
    In Vivo

    Creatine (0.1-1000 mg/kg, po, single dose) exhibits antidepressant-like activity in mouse tail suspension test, which could be enhanced by dopamine receptor agonist SKF38393 (HY-12520A) and Apomorphine (HY-12723)[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mouse tail suspension test[4]
    Dosage: 0.1-1000 mg/kg
    Administration: po, single dose
    Result: Reduced the immobility time of mice in the tail suspension test.
    Molecular Weight

    131.13

    Formula

    C4H9N3O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CN(C(N)=N)CC(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 6.25 mg/mL (47.66 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.6260 mL 38.1301 mL 76.2602 mL
    5 mM 1.5252 mL 7.6260 mL 15.2520 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 20 mg/mL (152.52 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.95%

    SDS (393 KB)

    COA (243 KB) HNMR (221 KB) RP-HPLC (258 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 7.6260 mL 38.1301 mL 76.2602 mL 190.6505 mL
    5 mM 1.5252 mL 7.6260 mL 15.2520 mL 38.1301 mL
    10 mM 0.7626 mL 3.8130 mL 7.6260 mL 19.0650 mL
    15 mM 0.5084 mL 2.5420 mL 5.0840 mL 12.7100 mL
    20 mM 0.3813 mL 1.9065 mL 3.8130 mL 9.5325 mL
    25 mM 0.3050 mL 1.5252 mL 3.0504 mL 7.6260 mL
    30 mM 0.2542 mL 1.2710 mL 2.5420 mL 6.3550 mL
    40 mM 0.1907 mL 0.9533 mL 1.9065 mL 4.7663 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Creatine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Creatine57-00-1Endogenous MetaboliteDopamine ReceptorInhibitorinhibitorinhibit

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