2. Metabolic Enzyme/Protease PI3K/Akt/mTOR
  3. Endogenous Metabolite PI3K Akt
  4. Creatine monohydrate

Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

For research use only. We do not sell to patients.

CAS No. : 6020-87-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water In-stock
Solid
100 mg In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Creatine monohydrate:

Creatine monohydrate Related Antibodies

Top Publications Citing Use of Products

    Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2426135122.  [Abstract]

    SPR analysis showed Creatine (25 μM) binding to hCRT, with a dissociation constant (KD) of 3.2 μM.

    Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956.  [Abstract]

    Creatine (10, 100, and 1,000 µmol/L; 24 h) stimulates type I IFN induction via the cGAMP–cGAS–STING–IRF3 signaling axis. 2030-cGAMP was robustly induced in monocytes following Creatine treatment.

    Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956.  [Abstract]

    Examination of cGAS-STING downstream signaling in monocytes by flow cytometry revealed activation of the STING-TBK1-IRF3 signaling axis following Creatine (10, 100, and 1,000 µmol/L; 24 h) treatment.

    Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956.  [Abstract]

    Combination of LNP-Gsdme and Creatine (10.5 mg/mice; once daily; IT) synergistically suppresses tumor growth. Tumor growth curves, tumor images, and tumor weights of B16F10 and 4T1 tumor–bearing mice treated with LNP-Gsdme/GFP or combined with Creatine.

    Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139.  [Abstract]

    The syngeneic mouse MC38 CRC model was utilized to examine how Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) supplementation, with or without the addition of anti-PD-1 antibody, affected tumor growth and survival. Tumor growth, tumor weights, and survival curves were recorded for the MC38 model mice given the different therapies. Combination therapy significantly suppressed tumor growth and prolonged survival of MC38 tumor-bearing immunocompetent C57BL/6 J mice compared to either single-agent or control-treated groups.

    Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139.  [Abstract]

    Tumor growth curve and tumor weights of DLD1 xenografts after indicated treatment.To ascertain whether Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) exhibits an inhibitory effect on tumor progression, a DLD-1 xenograft model was established, and Creatine was found to remarkably inhibit tumor development.

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    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    In Vitro

    Creatine monohydrate (10-20 mM, 1-3 weeks) promotes the cell growth, differentiation and mineralization of osteoblast-like cells[2].
    Creatine monohydrate (0.1-10 mM, 2-24 h) scanvages the free radicals, protects the DNA especially mtDNA from oxidative damage[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Creatine monohydrate Related Antibodies
    In Vivo

    Creatine monohydrate (0.1-1000 mg/kg, po, single dose) exhibits antidepressant-like activity in mouse tail suspension test, which could be enhanced by dopamine receptor agonist SKF38393 (HY-12520A) and Apomorphine (HY-12723)[4].
    Creatine monohydrate (0.03-0.3 mg/kg, drinking water for 8 weeks) stimulates the PI3K/AKT signaling pathways, promotes the protein synthesis and muscle hypertrophy, thereby promoting the performance of short-duration, high-intensity exercise in rats models[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Rats models[5]
    Dosage: 0.03-0.3 mg/kg
    Administration: drinking water for 8 weeks
    Result: Increased the perimeter and area of the soleus muscle.
    Clinical Trial
    Molecular Weight

    149.15

    Formula

    C4H11N3O3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)CN(C(N)=N)C.[H]O[H]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 16.67 mg/mL (111.77 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.7047 mL 33.5233 mL 67.0466 mL
    5 mM 1.3409 mL 6.7047 mL 13.4093 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.98%

    SDS (393 KB)

    COA (245 KB) HNMR (228 KB) RP-HPLC (206 KB) LCMS (95 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.7047 mL 33.5233 mL 67.0466 mL 167.6165 mL
    5 mM 1.3409 mL 6.7047 mL 13.4093 mL 33.5233 mL
    10 mM 0.6705 mL 3.3523 mL 6.7047 mL 16.7617 mL
    15 mM 0.4470 mL 2.2349 mL 4.4698 mL 11.1744 mL
    20 mM 0.3352 mL 1.6762 mL 3.3523 mL 8.3808 mL
    25 mM 0.2682 mL 1.3409 mL 2.6819 mL 6.7047 mL
    30 mM 0.2235 mL 1.1174 mL 2.2349 mL 5.5872 mL
    40 mM 0.1676 mL 0.8381 mL 1.6762 mL 4.1904 mL
    50 mM 0.1341 mL 0.6705 mL 1.3409 mL 3.3523 mL
    60 mM 0.1117 mL 0.5587 mL 1.1174 mL 2.7936 mL
    80 mM 0.0838 mL 0.4190 mL 0.8381 mL 2.0952 mL
    100 mM 0.0670 mL 0.3352 mL 0.6705 mL 1.6762 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Creatine monohydrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Creatine6020-87-7Endogenous MetabolitePI3KAktPhosphoinositide 3-kinasePKBProtein kinase BInhibitorinhibitorinhibit

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