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Results for "

( )-Irinotecan hydrochloride

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Payload (4) Adrenergic Receptor (1) Akt (1) Amyloid-β (1) Antibiotic (1) Apoptosis (4) ATP Synthase (1) Autophagy (15) Bacterial (2) BCRP (3) Biochemical Assay Reagents (5) Calcium Channel (1) Calmodulin (1) Carboxylesterase (CES) (3) Caspase (1) CDK (1) Cholinesterase (ChE) (6) Claudin (1) CRFR (1) Dopamine Receptor (2) Drug Derivative (1) Drug Intermediate (7) Drug Metabolite (10) Drug-Linker Conjugates for ADC (6) EGFR (1) Endogenous Metabolite (2) Environmental Pollutants (1) FKBP (1) Fluorescent Dye (1) FXR (1) GLUT (1) HDAC (1) iGluR (2) Imidazoline Receptor (1) Integrin (1) Isotope-Labeled Compounds (9) Lactate Dehydrogenase (1) Ligands for Target Protein for PROTAC (1) Liposome (1) mAChR (3) MAP4K (1) Mitochondrial Metabolism (1) Natriuretic Peptide Receptor (NPR) (1) PARP (1) Peptide-Drug Conjugates (PDCs) (1) Potassium Channel (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (10) Serotonin Transporter (1) Sodium Channel (1) Topoisomerase (24) Transthyretin (TTR) (1) Wnt (1) α-synuclein (1) β-catenin (1) β-glucuronidase (1)
By Research Areas:	Cancer (56) Cardiovascular Disease (2) Endocrinology (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (5) Neurological Disease (17)
Oligonucleotides:	Liposome (1) Polymers (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13704

SN-38 65+ Cited Publications 7-Ethyl-10-hydroxycamptothecin	Drug Metabolite Topoisomerase ADC Payload Autophagy	Infection Cancer
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .

HY-16562

*Irinotecan* Maximum Cited Publications 75 Publications Verification (+)-Irinotecan; CPT-11; VAL-413free base	Topoisomerase Autophagy	Neurological Disease Cancer
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-16562A

Irinotecan hydrochloride 70+ Cited Publications (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413	Topoisomerase Autophagy	Cancer
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-16568

Irinotecan hydrochloride trihydrate Maximum Cited Publications 75 Publications Verification (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate	Topoisomerase Autophagy	Cancer
Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity .

HY-126373

SN-38 glucuronide SN-38G	Drug Metabolite	Cancer
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-145514C

dTAGV-1 hydrochloride 5 Publications Verification	FKBP PROTACs	Cancer
dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12 ^F36V-tagged proteins PROTAC degrader. dTAGV-1 hydrochloride can induce degradation of FKBP12 ^F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A)) .

HY-101374A

AGN 192403 hydrochloride (+)-BRD4780	Imidazoline Receptor Caspase Mitochondrial Metabolism Lactate Dehydrogenase	Cardiovascular Disease Neurological Disease Cancer
AGN 192403 (BRD4780) hydrochloride is a potent and selective imidazoline-1 receptor antagonist with a K_i value of 42 nM. AGN 192403 hydrochloride is also a TMED9 inhibitor. AGN 192403 hydrochloride shows protective effects on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. AGN 192403 hydrochloride mitigates the proliferation and migration of differentiated glioma tumor cells. AGN 192403 hydrochloride can be used for glioma tumor and neurological diseases research .

HY-13704S

SN-38-d3 NK012-d₃	Topoisomerase ADC Payload Autophagy	Cancer
SN-38-d₃ is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively .

HY-107922

Ethopropazine hydrochloride 1 Publications Verification Isothazine	Cholinesterase (ChE) iGluR mAChR	Neurological Disease
Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease .

HY-113283

Homogentisic acid	Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin	Neurological Disease Metabolic Disease Cancer
Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ_1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .

HY-153013

SN38-COOH	Drug-Linker Conjugates for ADC	Cancer
SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis .

HY-B0194A

Tizanidine hydrochloride	Adrenergic Receptor Apoptosis Akt Wnt β-catenin	Neurological Disease Endocrinology Cancer
Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI) .

HY-12758

YHO-13351	BCRP	Cancer
YHO-13351 is an orally active ABCG2 inhibitor . YHO-13351 modulates the function of ABCG2, blocks BCRP-mediated compound efflux, downregulates the expression of breast cancer resistance protein at the post-transcriptional level, and reverses ABCG2-associated tolerance. YHO-13351 restores the toxicity of SN-38 to SN-38-resistant cancer cells and sensitizes cancer cells to Irinotecan. YHO-13351 is a water-soluble prodrug that is rapidly converted to YHO-13177 (HY-12757) in mice. YHO-13351 prolongs the median survival time of mice bearing cancer cell xenografts when combined with IMMU-132. YHO-13351 extends the survival time of tumor-bearing mice and inhibits the growth of xenograft tumors when combined with Irinotecan. YHO-13351 can be used for the research of breast cancer, gastric cancer, BCRP-mediated drug-resistant cancers, and cervical cancer .

HY-W250727

TNS sodium 1 Publications Verification 6-(p-Tolylamino)naphthalene-2-sulfonate sodium	Fluorescent Dye	Others
TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .

HY-139909A

CL2E-SN38 TFA 1 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
CL2E-SN-38 TFA, a highly releasable and structurally stable antibody-SN-38-conjugate, is a part of the antibody drug conjugate (ADC). SN-38, the active metabolite of Irinotecan from camptothecins, is an Topoisomerase I inhibitor .

HY-126534A

Abemaciclib metabolite M18 hydrochloride 2 Publications Verification LSN3106729 hydrochloride	Ligands for Target Protein for PROTAC CDK	Cancer
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .

HY-136170

MC-SN38 2 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks .

HY-13704R

SN-38 (Standard) 7-Ethyl-10-hydroxycamptothecin (Standard)	Drug Metabolite Reference Standards Topoisomerase ADC Payload Autophagy	Cancer
SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .

HY-12757

YHO-13177 2 Publications Verification	BCRP	Cancer
YHO-13177, a acrylonitrile derivative, is an orally active, potent and specific inhibitor of breast cancer resistance protein (BCRP) and ABCG2 with an IC₅₀ value of 10 nM. YHO-13177 potentiates the cytotoxicity of SN-38 in HCT116 and A549 cells that express BCRP. YHO-13177 combined with Irinotecan (HY-16562) significantly suppresses the tumor growth in an HCT116/BCRP xenograft model .

HY-W012161

Alanylphenylalanine L-Alanyl-L-phenylalanine; H-Ala-Phe-OH	Endogenous Metabolite Drug Intermediate	Others
Alanylphenylalanine (L-Alanyl-L-phenylalanine) is a dipeptide. Alanylphenylalanine forms a mononuclear Au (III) complex through bidentate coordination via its carboxyl oxygen atom and deprotonated amide nitrogen atom .

HY-145396

PLGA12000-PEG2000-NH2	Biochemical Assay Reagents	Cancer
PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma .

HY-U00443

SB 258719	5-HT Receptor	Neurological Disease Cancer
SB 258719 is a selective 5-HT₇ receptor antagonist with high affinity (pK_i=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease .

HY-16562S1

Irinotecan-d10 hydrochloride	Isotope-Labeled Compounds Topoisomerase Autophagy	Cancer
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-W012985

Methyl pyruvate	ATP Synthase Apoptosis	Metabolic Disease Cancer
Methyl pyruvate is a methyl ester derivative of pyruvic acid. Methyl pyruvate induces insulin release and membrane depolarization. Methyl pyruvate rescues proteasome damage and nuclear localization of TdP-43 caused by overexpression of σ1RE102Q by enhancing ATP synthesis. Methyl pyruvate selectively protects normal lung fibroblasts from cell death induced by Irinotecan (HY-16562). Methyl pyruvate promotes apoptosis and necrosis in cancer cells and downregulates angiogenesis and cell cycle pathways. Methyl pyruvate is an effective substrate for dihydrodihydrogen dehydrogenase.

HY-146269

11-Desethyl Irinotecan	Drug Metabolite	Cancer
11-Desethyl Irinotecan is a camptothecin (CPT) analog and one of the metabolites of irinotecan. It is promising for cancer research .

HY-100620

RPR121056 APC	Topoisomerase Cholinesterase (ChE)	Cancer
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE .

HY-173243A

Val-Ala-PAB-SN38 TFA	Drug-Linker Conjugates for ADC	Cancer
Val-Ala-PAB-SN38 TFA is a drug-linker conjugate for ADC, composed of ADC linker Val-Ala-PAB (HY-125933) and SN38 (HY-13704), which is the active metabolite of the Topoisomerase I inhibitor Irinotecan (HY-16562) .

HY-Y0024

4-Methoxyacetophenone	Environmental Pollutants Drug Intermediate	Others
4-Methoxyacetophenone is a versatile aromatic ketone that is widely used in the synthesis of various organic compounds. 4-Methoxyacetophenone has a pleasant aroma and can be used to create scents. 4-Methoxyacetophenone can also be used to make dyes and pigments .

HY-W145090

4-Dimethylaminopyridine N-oxide p-Dimethylaminopyridine N-oxide	Biochemical Assay Reagents	Others
4-Dimethylaminopyridine N-oxide (p-Dimethylaminopyridine N-oxide) is an Efficient Oxidizing Agent for Alkyl Halides .

HY-126373S1

SN-38 glucuronide-13C6 SN-38G-¹³C₆	Isotope-Labeled Compounds	Others
SN-38 glucuronide- ¹³C₆ is the ¹³C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-103123

SB 258719 hydrochloride	5-HT Receptor	Neurological Disease Cancer
SB 258719 hydrochloride is a selective 5-HT₇ receptor antagonist displayed high affnity (pK_i=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases .

HY-155181

CES2-IN-1	Carboxylesterase (CES)	Cancer
CES2-IN-1 (Compound 24) is a reversible and selective CES2 inhibitor (IC₅₀: 6.72 μM for human CES2). CES2-IN-1 reduces the level of CES2 in living cells. CES2-IN-1 is effective against Irinotecan (HY-16562)-induced delayed diarrhea and DSS-induced ulcerative colitis .

HY-A0236A

Aprindine hydrochloride	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-101100

Anpirtoline hydrochloride D-16949 hydrochloride	5-HT Receptor	Neurological Disease
Anpirtoline (D-16949) hydrochloride is a centrally acting 5-HT_1B receptor agonist, with K_is of 28 nM (5-HT_1B), 150 nM (5-HT_1A) and 1.49 μM (5-HT2). Anpirtoline hydrochloride has serotonergic, antinociceptive, antidepressant-like effects .

HY-139909

CL2E-SN38	Drug-Linker Conjugates for ADC	Cancer
CL2E-SN-38, a highly releasable and structurally stable antibody-SN-38-conjugate, is a part of the antibody drug conjugate (ADC). SN-38, the active metabolite of Irinotecan from camptothecins, is an Topoisomerase I inhibitor .

HY-19562A

PF-06260933 hydrochloride 4 Publications Verification	MAP4K	Inflammation/Immunology
PF-06260933 hydrochloride is the hydrochloride form of PF-06260933 (HY-19562). PF-06260933 hydrochloride is an orally active and highly selective inhibitor of MAP4K4 with IC₅₀s of 3.7 and 160 nM for kinase and cell, respectively .

HY-114549

(R)-SCH-23982 hydrochloride	Dopamine Receptor	Neurological Disease
(R)-SCH-23982 hydrochloride is the R-enantiomer of SCH-23982 hydrochloride. SCH-23982 hydrochloride is a selective dopamine D1 receptor antagonist. (R)-SCH-23982 hydrochloride is promising for research of central nervous system disorders such as schizophrenia, Parkinson’s disease .

HY-P10783

BGC0222	Peptide-Drug Conjugates (PDCs) Integrin	Cancer
BGC0222 is a novel prodrug of Irinotecan (HY-16562). BGC0222, as a PEG-cRGD-conjugated Irinotecan (HY-16562) derivative, could slowly and steadily release Irinotecan (HY-16562). BGC0222 binds to α_Vβ₃ with IC₅₀ values of 4.25 μM (α_Vβ₃) and 58.7 μM (α_Vβ₅). BGC0222 possesses the property of inducing neovascularization. BGC0222 exhibits good antiproliferation activity in many tumors .

HY-138813

N-Desethyl Sunitinib hydrochloride 5+ Cited Publications SU-12662 hydrochloride	Drug Metabolite	Cancer
N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with K_i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .

HY-N1777

3,4-Dimethoxybenzamide	Drug Intermediate	Others
3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride .

HY-103376

NBI-27914 hydrochloride	CRFR	Neurological Disease
NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a K_i value of 1.7 nM .

HY-173243

Val-Ala-PAB-SN38	Drug-Linker Conjugates for ADC	Cancer
Val-Ala-PAB-SN38 is a drug-linker conjugate for ADC, composed of ADC linker Val-Ala-PAB (HY-125933) and SN38 (HY-13704), which is the active metabolite of the Topoisomerase I inhibitor Irinotecan (HY-16562) .

HY-101820A

Simotinib hydrochloride	EGFR	Cancer
Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC₅₀ of 19.9 nM. Antineoplastic activities .

HY-116459

trans-Cevimeline hydrochloride AF102A hydrochloride	mAChR	Neurological Disease
Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease .

HY-16568R

Irinotecan hydrochloride trihydrate (Standard) (+)-Irinotecan hydrochloride trihydrate (Standard); CPT-11 hydrochloride trihydrate (Standard)	Reference Standards Topoisomerase Autophagy	Cancer
Irinotecan (hydrochloride trihydrate) (Standard) is the analytical standard of Irinotecan (hydrochloride trihydrate). This product is intended for research and analytical applications. Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity .

HY-16562AR

Irinotecan hydrochloride (Standard) (+)-Irinotecan hydrochloride (Standard); CPT-11 hydrochloride (Standard); VAL-413 (Standard)	Reference Standards Topoisomerase Autophagy	Cancer
Irinotecan (hydrochloride) (Standard) is the analytical standard of Irinotecan (hydrochloride). This product is intended for research and analytical applications. Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-16562R

Irinotecan (Standard) (+)-Irinotecan (Standard); CPT-11 (Standard); VAL-413free base (Standard)	Reference Standards Topoisomerase Autophagy	Cancer
Irinotecan (Standard) is the analytical standard of Irinotecan. This product is intended for research and analytical applications. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-16562S

Irinotecan-d10 (+)-Irinotecan-d10; CPT-11-d10; VAL-413-d10free base	Topoisomerase Autophagy	Cancer
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-131174

8-Ethyl Irinotecan	Biochemical Assay Reagents	Others
8-Ethyl Irinotecan (compound H) is a impurity of Irinotecan hydrochloride (HY-16562A) .

HY-16562AS

Irinotecan-d5 hydrochloride (+)-Irinotecan-d5 (hydrochloride; CPT-11-d5 hydrochloride; VAL-413-d5	Autophagy Topoisomerase Isotope-Labeled Compounds	Cancer
Irinotecan-d₅ hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

Cat. No.	Product Name	Type

HY-W250727

TNS sodium

1 Publications Verification

6-(p-Tolylamino)naphthalene-2-sulfonate sodium

Biochemical Assay Reagents

TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .

HY-145396

PLGA12000-PEG2000-NH2	Biochemical Assay Reagents
PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma .

HY-Y0024

4-Methoxyacetophenone	Biochemical Assay Reagents
4-Methoxyacetophenone is a versatile aromatic ketone that is widely used in the synthesis of various organic compounds. 4-Methoxyacetophenone has a pleasant aroma and can be used to create scents. 4-Methoxyacetophenone can also be used to make dyes and pigments .

Cat. No.	Product Name	Target	Research Area

HY-P10783

BGC0222	Peptide-Drug Conjugates (PDCs) Integrin	Cancer
BGC0222 is a novel prodrug of Irinotecan (HY-16562). BGC0222, as a PEG-cRGD-conjugated Irinotecan (HY-16562) derivative, could slowly and steadily release Irinotecan (HY-16562). BGC0222 binds to α_Vβ₃ with IC₅₀ values of 4.25 μM (α_Vβ₃) and 58.7 μM (α_Vβ₅). BGC0222 possesses the property of inducing neovascularization. BGC0222 exhibits good antiproliferation activity in many tumors .

HY-P11692

Fmoc-Aeg-OtBu	Drug Intermediate	Others
Fmoc-Aeg-OtBu is an intermediate in solid-phase peptide synthesis, and serves as a building block for introducing pseudoproline motifs or backbone modifications .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13704

SN-38 65+ Cited Publications 7-Ethyl-10-hydroxycamptothecin	Alkaloids Structural Classification Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Quinoline Alkaloids Plants Disease Research Fields Source Classification Cancer	Drug Metabolite Topoisomerase ADC Payload Autophagy
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .

HY-16562A

Irinotecan hydrochloride 70+ Cited Publications (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413	Alkaloids Classification of Application Fields Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Source Classification Cancer	Topoisomerase Autophagy
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-113283

Homogentisic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin
Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ_1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .

HY-13704R

SN-38 (Standard) 7-Ethyl-10-hydroxycamptothecin (Standard)	Alkaloids Labiatae Samanea saman (Jacq.) Merr. Quinoline Alkaloids Plants Source Classification	Drug Metabolite Reference Standards Topoisomerase ADC Payload Autophagy
SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .

HY-W012161

Alanylphenylalanine L-Alanyl-L-phenylalanine; H-Ala-Phe-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate
Alanylphenylalanine (L-Alanyl-L-phenylalanine) is a dipeptide. Alanylphenylalanine forms a mononuclear Au (III) complex through bidentate coordination via its carboxyl oxygen atom and deprotonated amide nitrogen atom .

HY-N1777

3,4-Dimethoxybenzamide	Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Drug Intermediate
3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride .

HY-16562AR

Irinotecan hydrochloride (Standard) (+)-Irinotecan hydrochloride (Standard); CPT-11 hydrochloride (Standard); VAL-413 (Standard)	Alkaloids Structural Classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Source Classification	Reference Standards Topoisomerase Autophagy
Irinotecan (hydrochloride) (Standard) is the analytical standard of Irinotecan (hydrochloride). This product is intended for research and analytical applications. Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-N9910

Visamminol	Ketones, Aldehydes, Acids Artemisia cana Pursh Umbelliferae Plants Source Classification	Endogenous Metabolite
Visamminol is a spasmolytic which can be extracted from Cimicifuga dahurica. Visamminol exhibits a spasmolytic action that is one-third as potent as that of papaverine hydrochloride .

HY-N1777R

3,4-Dimethoxybenzamide (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Drug Intermediate
3,4-Dimethoxybenzamide (Standard) is the analytical standard of 3,4-Dimethoxybenzamide. This product is intended for research and analytical applications. 3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride[1][2].

HY-N20291

Fagarine II	Structural Classification Alkaloids Other Alkaloids Rutaceae Zanthoxylum coco Gillies ex Hook. & Arn. Plants Source Classification	Others
Fagarine II is an alkaloid found in the leaves and twigs of Fagara coco. Alkaloids are a large class of complex nitrogen-containing basic organic compounds. As food, nutritional supplements, and medicines, alkaloids play an important role in medicine and other fields. Alkaloid compounds exhibit good biological activities in anti-inflammatory, anticancer, analgesic, local anesthetic, neuropharmacological, antibacterial, and antifungal properties .

Cat. No.	Product Name	Chemical Structure

HY-13704S

SN-38-d3
SN-38-d₃ is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively .

HY-16562S1

Irinotecan-d10 hydrochloride
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-126373S1

SN-38 glucuronide-13C6
SN-38 glucuronide- ¹³C₆ is the ¹³C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-16562AS

Irinotecan-d5 hydrochloride
Irinotecan-d₅ hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-132561S

RPR121056-d3
RPR121056-d3 is the deuterium labeled RPR121056. RPR121056 is a metabolite of Irinotecan (HY-16562), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the study of colorectal cancer. Irinotecan also directly inhibits AChE .

HY-W653919

SN-38 glucuronide-d3
SN-38 glucuronide-d₃ is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-132545S

RPR132595A-d3
RPR132595A-d₃ is the deuterium labeled RPR132595A. RPR132595A is an active metabolite of Irinotecan (CPT-11), which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine .

HY-16562S2

Irinotecan-13C6
Irinotecan- ¹³C₆ ((+)-Irinotecan- ¹³C₆) is the ¹³C-labeled Irinotecan (HY-16562). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-126373S

SN-38 glucuronide-d5
SN-38 glucuronide-d₅ (SN-38G-d₅) is the deuterium labeled SN-38 glucuronide (HY-126373). SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.

HY-13704S2

SN-38-13C6
SN-38- ¹³C₆ (7-Ethyl-10-hydroxycamptothecin- ¹³C₆) is the ¹³C-labeled SN-38 (HY-13704). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .

Cat. No.	Product Name		Classification

HY-145396

PLGA12000-PEG2000-NH2		Polymers
PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma .

HY-185371

Irinotecan liposome Irinotecan hydrochlorid liposomee; Liposomal Irinotecan		Liposome
Irinotecan liposome is a liposome-encapsulated form of Irinotecan hydrochlorid (HY-16562A) (a topoisomerase I inhibitor). Compared with Irinotecan, Irinotecan liposome enhances antitumor activity, reduces drug release rate, and avoids neutropenia.

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