2. Membrane Transporter/Ion Channel Apoptosis
  3. ATP Synthase Apoptosis
  4. Methyl pyruvate

Methyl pyruvate is a methyl ester derivative of pyruvic acid. Methyl pyruvate induces insulin release and membrane depolarization. Methyl pyruvate rescues proteasome damage and nuclear localization of TdP-43 caused by overexpression of σ1RE102Q by enhancing ATP synthesis. Methyl pyruvate selectively protects normal lung fibroblasts from cell death induced by Irinotecan (HY-16562). Methyl pyruvate promotes apoptosis and necrosis in cancer cells and downregulates angiogenesis and cell cycle pathways. Methyl pyruvate is an effective substrate for dihydrodihydrogen dehydrogenase.

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Methyl pyruvate

Methyl pyruvate Chemical Structure

CAS No. : 600-22-6

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Methyl pyruvate Related Antibodies

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Description

Methyl pyruvate is a methyl ester derivative of pyruvic acid. Methyl pyruvate induces insulin release and membrane depolarization. Methyl pyruvate rescues proteasome damage and nuclear localization of TdP-43 caused by overexpression of σ1RE102Q by enhancing ATP synthesis. Methyl pyruvate selectively protects normal lung fibroblasts from cell death induced by Irinotecan (HY-16562). Methyl pyruvate promotes apoptosis and necrosis in cancer cells and downregulates angiogenesis and cell cycle pathways. Methyl pyruvate is an effective substrate for dihydrodihydrogen dehydrogenase.

Molecular Weight

102.09

Formula

C4H6O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC)C(=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (1959.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.7953 mL 48.9764 mL 97.9528 mL
5 mM 1.9591 mL 9.7953 mL 19.5906 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

SDS (466 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 9.7953 mL 48.9764 mL 97.9528 mL 244.8820 mL
5 mM 1.9591 mL 9.7953 mL 19.5906 mL 48.9764 mL
10 mM 0.9795 mL 4.8976 mL 9.7953 mL 24.4882 mL
15 mM 0.6530 mL 3.2651 mL 6.5302 mL 16.3255 mL
20 mM 0.4898 mL 2.4488 mL 4.8976 mL 12.2441 mL
25 mM 0.3918 mL 1.9591 mL 3.9181 mL 9.7953 mL
30 mM 0.3265 mL 1.6325 mL 3.2651 mL 8.1627 mL
40 mM 0.2449 mL 1.2244 mL 2.4488 mL 6.1220 mL
50 mM 0.1959 mL 0.9795 mL 1.9591 mL 4.8976 mL
60 mM 0.1633 mL 0.8163 mL 1.6325 mL 4.0814 mL
80 mM 0.1224 mL 0.6122 mL 1.2244 mL 3.0610 mL
100 mM 0.0980 mL 0.4898 mL 0.9795 mL 2.4488 mL
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Methyl pyruvate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl pyruvate600-22-6ATP SynthaseApoptosisInsulin secretionmitochondrial ATP productionendoplasmic reticulum stressamyotrophic lateral sclerosisTDP-43chemotherapy protectionWarburg effectapoptosissigma-1 receptor.Inhibitorinhibitorinhibit

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