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Cat. No.: HY-13704S2

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SN-38-¹³C₆

(Synonyms: 7-Ethyl-10-hydroxycamptothecin-¹³C₆)

SN-38-¹³C₆ (7-Ethyl-10-hydroxycamptothecin-¹³C₆) is the ¹³C-labeled SN-38 (HY-13704). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).

For research use only. We do not sell to patients.

CAS No.: 718612-55-6
Formula: C₁₆¹³C₆H₂₀N₂O₅
Molecular Weight:398.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SN-38-¹³C₆ Chemical Structure

CAS No.: 718612-55-6

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Topoisomerase Isoforms :

All ADC Payloads Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 718612-55-6
Unlabeled Cas 86639-52-3
Molecular Weight 398.36
Formula C₁₆¹³C₆H₂₀N₂O₅
SMILES

CCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=N[13C]5=[13CH][13CH]=[13C](O)[13CH]=[13C]51
Synonyms

7-Ethyl-10-hydroxycamptothecin-¹³C₆
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.