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  3. NBI-27914 hydrochloride

NBI-27914 hydrochloride 

Cat. No.: HY-103376
Handling Instructions

NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM.

For research use only. We do not sell to patients.

NBI-27914 hydrochloride Chemical Structure

NBI-27914 hydrochloride Chemical Structure

CAS No. : 1215766-76-9

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Description

NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM[1][3][4].

IC50 & Target

Ki: 1.7 nM (CRF1 receptor)[4]

In Vivo

NBI 27914 (3~30 mg/kg; i.p.) hydrochloride attenuates the referred abdominal pain at the highest dose tested, it is efficacious both 4 and 24 h post-indomethacin dosing[1].
NBI 27914 (1~10 mg/kg; i.p.) hydrochloride dose dependently attenuates Freund's Complete Adjuvant-induced mechanical hyperalgesia. NBI 27914 (10 mg/kg) hydrochloride reverses the thermal hyperalgesia. NBI 27914 hydrochloride attenuates spinal nerve ligation-induced mechanical hyperalgesia and tactile allodynia with minimal effective doses equal to 5 and 10 mg/kg, respectively[1]. The higher doses of NBI 27914 hydrochloride blocks the behavioral seizures and prevents epileptic discharges in concurrent electroencephalograms recorded from the amygdala[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice (20~25 g)[1]
Dosage: 3~30 mg/kg
Administration: I.p.
Result: Attenuated the referred abdominal pain at the highest dose tested, it was efficacious both 4 and 24 h post-indomethacin dosing.
Molecular Weight

470.65

Formula

C₁₈H₂₁Cl₅N₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
NBI-27914 hydrochloride
Cat. No.:
HY-103376
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