1215766-76-9
1215766-76-9
Chemical Structure
NBI-27914 hydrochloride
- CAS No.: 1215766-76-9
- Formula:C18H21Cl5N4
- Molecular Weight:470.65
IUPAC Name: 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine hydrochloride
InChIKey: CPMGENCTAWBLNW-UHFFFAOYSA-N
SMILES: CCCN(C1=NC(C)=NC(NC2=C(C=C(Cl)C=C2Cl)Cl)=C1Cl)CC3CC3.Cl
Biological Activity: NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM[1][3][4].
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NBI-27914 hydrochloride | NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM. | |||||||||||||||||||||
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References
- [1]. Peng YL, et al. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31(12):2259-2263. [Content Brief]
- [3]. Baram TZ, et al. The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997;770(1-2):89-95. [Content Brief]
- [4]. Chen C, et al. Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J Med Chem. [Content Brief]
Keywords
