2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Simotinib hydrochloride

Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities.

For research use only. We do not sell to patients.

Simotinib hydrochloride Chemical Structure

Simotinib hydrochloride Chemical Structure

CAS No. : 1538617-88-7

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Simotinib hydrochloride Related Antibodies

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Description

Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities[1].

IC50 & Target

EGFR

19.9 nM (pIC50)

In Vitro

Simotinib hydrochloride inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Simotinib hydrochloride Related Antibodies
In Vivo

Simotinib hydrochloride has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

537.41

Formula

C25H27Cl2FN4O4
CAS No.
SMILES

COC1=CC2=C(C(NC(C=C3)=CC(Cl)=C3F)=NC=N2)C=C1OCCN4CC5(CC5)C6(OCCO6)C4.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Simotinib hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Simotinib1538617-88-7EGFREpidermal growth factor receptorErbB-1HER1hydrochlorideselectivespecificorallybioavailableantineoplasticInhibitorinhibitorinhibit

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