1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Simotinib hydrochloride

Simotinib hydrochloride 

Cat. No.: HY-101820A
Handling Instructions

Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities.

For research use only. We do not sell to patients.

Simotinib hydrochloride Chemical Structure

Simotinib hydrochloride Chemical Structure

CAS No. : 1538617-88-7

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Description

Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities[1].

IC50 & Target

EGFR

19.9 nM (pIC50)

In Vitro

Simotinib hydrochloride inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Simotinib hydrochloride has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

537.41

Formula

C₂₅H₂₇Cl₂FN₄O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Simotinib hydrochloride
Cat. No.:
HY-101820A
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