1538617-88-7
1538617-88-7
Chemical Structure
Simotinib hydrochloride
- CAS No.: 1538617-88-7
- Formula:C25H27Cl2FN4O4
- Molecular Weight:537.41
IUPAC Name: 6-(2-(5,8-dioxa-10-azadispiro[2.0.44.33]undecan-10-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine hydrochloride
InChIKey: RNEAUPHMDFWZDA-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C(NC(C=C3)=CC(Cl)=C3F)=NC=N2)C=C1OCCN4CC5(CC5)C6(OCCO6)C4.Cl
Biological Activity: Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities[1].
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Simotinib hydrochloride | Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities. | |||||||||||||||||||||
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References
Keywords
