1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Tizanidine hydrochloride

Tizanidine hydrochloride 

Cat. No.: HY-B0194A Purity: 99.67%
Handling Instructions

Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

For research use only. We do not sell to patients.

Tizanidine hydrochloride Chemical Structure

Tizanidine hydrochloride Chemical Structure

CAS No. : 64461-82-1

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 108 In-stock
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100 mg USD 132 In-stock
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Description

Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Target: α2-adrenergic receptor Tizanidine is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia. Tizanidine has been found to be as effective as other antispasmodic drugs and has superior tolerability to that of baclofen and diazepam. Tizanidine can be very strong even at the 2 mg dose and may cause hypotension, so caution is advised when it is used in patients who have a history of orthostatic hypotension, or when switching from gel cap to tablet form and vice versa. Tizanidine can occasionally cause liver damage, generally the hepatocellular type. Clinical trials show that up to 5% of patients treated with tizanidine had elevated liver function test values, though symptoms disappeared upon withdrawal of the drug. Care should be used when first beginning treatment with tizanidine with regular liver tests for the first 6 months of treatment.

Clinical Trial
Molecular Weight

290.17

Formula

C₉H₉Cl₂N₅S

CAS No.

64461-82-1

SMILES

ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (68.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4463 mL 17.2313 mL 34.4626 mL
5 mM 0.6893 mL 3.4463 mL 6.8925 mL
10 mM 0.3446 mL 1.7231 mL 3.4463 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.67%

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Keywords:

TizanidineAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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Tizanidine hydrochloride
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HY-B0194A
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