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Cat. No.: HY-155034

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Antitumor agent-102

Antitumor agent-102 (compound 10) is a conjugate of Topoisomerase I inhibitor SN38 and glucose transporter inhibitor, targeting to colorectal cancer. Antitumor agent-102 induces higher concentrations of free SN38 in tumor tissues than Irinotecan (HY-16562).

For research use only. We do not sell to patients.

CAS No.: 2956876-32-5
Formula: C₇₀H₈₂N₈O₁₈S
Molecular Weight:1355.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Antitumor agent-102 Chemical Structure

CAS No.: 2956876-32-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Topoisomerase Isoforms :

All GLUT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	IC₅₀	4.59 μM Compound: 10	Cytotoxicity against human COLO 205 cells incubated for 48 hrs by SRB assay Cytotoxicity against human COLO 205 cells incubated for 48 hrs by SRB assay	[PMID: 37413981]
HCT-116	IC₅₀	7.43 μM Compound: 10	Cytotoxicity against human HCT-116 cells incubated for 48 hrs by SRB assay Cytotoxicity against human HCT-116 cells incubated for 48 hrs by SRB assay	[PMID: 37413981]
HT-29	IC₅₀	>100 μM Compound: 10	Cytotoxicity against human HT-29 cells incubated for 48 hrs by SRB assay Cytotoxicity against human HT-29 cells incubated for 48 hrs by SRB assay	[PMID: 37413981]

Chemical Information

CAS No. 2956876-32-5
Molecular Weight 1355.51
Formula C₇₀H₈₂N₈O₁₈S
SMILES

O=C(N1CCCCC(N[C@H](C(N[C@H](C(NC2=CC=C(C=C2)COC3=CC=C(C4=C3)N=C5C(N6CC5=C4CC)=CC([C@@](CC)7O)=C(C6=O)COC7=O)=O)CCCNC(N)=O)=O)C(C)C)=O)C(SCCOCCOCCOC8=CC(O)=C(C(O)=C8)C(CCC9=CC=C(C=C9)O)=O)CC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chiu PF, et al. Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal Cancer. J Med Chem. 2023 Jul 6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Antitumor agent-102

All Topoisomerase Isoforms

All GLUT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antitumor agent-102 Related Classifications

HY-155034 Related Classifications