2956876-32-5
Chemical Structure
Antitumor agent-102
- CAS No.: 2956876-32-5
- Formula:C70H82N8O18S
- Molecular Weight:1355.51
InChIKey: QXAMZNOQHCQNLY-USSFQMIRSA-N
SMILES: O=C(N1CCCCC(N[C@H](C(N[C@H](C(NC2=CC=C(C=C2)COC3=CC=C(C4=C3)N=C5C(N6CC5=C4CC)=CC([C@@](CC)7O)=C(C6=O)COC7=O)=O)CCCNC(N)=O)=O)C(C)C)=O)C(SCCOCCOCCOC8=CC(O)=C(C(O)=C8)C(CCC9=CC=C(C=C9)O)=O)CC1=O
Biological Activity: Antitumor agent-102 (compound 10) is a conjugate of Topoisomerase I inhibitor SN38 and glucose transporter inhibitor, targeting to colorectal cancer. Antitumor agent-102 induces higher concentrations of free SN38 in tumor tissues than Irinotecan (HY-16562)[1].
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Antitumor agent-102 | Antitumor agent-102 (compound 10) is a conjugate of Topoisomerase I inhibitor SN38 and glucose transporter inhibitor, targeting to colorectal cancer. Antitumor agent-102 induces higher concentrations of free SN38 in tumor tissues than Irinotecan (HY-16562). | |||||||||||||||||||||
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Keywords
