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Results for "

MFC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fungal (2) Histone Demethylase (1) PD-1/PD-L1 (1)
By Research Areas:	Cancer (1) Infection (2)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155115

LSD1-IN-27	Histone Demethylase PD-1/PD-L1	Cancer
LSD1-IN-27 (Compound 5ac) is a LSD1 inhibitor (IC₅₀: 13 nM). LSD1-IN-27 inhibits the stemness and migration of gastric cancer cells. LSD1-IN-27 also reduces the expression of PD-L1 in BGC-823 and MFC cells. LSD1-IN-27 can enhance T cell immune response in gastric cancer .

HY-127050

Tetramycin Tetramycin A	Fungal	Infection
Tetramycin (Tetramycin A) is an antifungal active substance of strain BS-112. Tetramycin inhibits *Aspergillus flavus* with the MFC (minimum fugicide concentration) is 3.13 μg/mL .

HY-151439

Antifungal agent 41	Fungal	Infection
Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections .

Tetramycin Tetramycin A	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Fungal
Tetramycin (Tetramycin A) is an antifungal active substance of strain BS-112. Tetramycin inhibits *Aspergillus flavus* with the MFC (minimum fugicide concentration) is 3.13 μg/mL .

Species:	Human (53) Virus (4) Mouse (7) Rat (2) Cynomolgus (3) Canine (2)
Tag:	His (2) Avi (9) Fc (71) Flag (1)
Source:	HEK293 (71)

Cat. No.	Compare	Product Name	Species	Source

HY-P70811

	*IL-13 Protein, Human (HEK293, mFc)* Interleukin-13; IL-13	Human	HEK293
	IL-13 Protein, Human (HEK 293, mFc) is a cytokine which affects the morphology, growth, and surface antigen expression and phenotype of monocytes and elicits B cell proliferation. IL-13 Protein, Human (HEK 293, mFc) is a recombinant human interleukin-13 (rhIL-13) expressed in HEK 293 cells with the mFc tag.

HY-P74626

	*PLGF Protein, Human (HEK293, mFc)* Placenta growth factor; PlGF; PGF; PGFL	Human	HEK293
	The PLGF-2 protein is a key growth factor for angiogenesis and endothelial cell growth, crucially stimulating cell proliferation and migration by binding to the FLT1/VEGFR-1 receptor. It coordinates the angiogenic process, regulates blood vessel growth, and exhibits additional binding capabilities to NRP1/neuropilin-1 and NRP2/neuropilin-2. PLGF Protein, Human (HEK293, mFc) is the recombinant human-derived PLGF protein, expressed by HEK293 , with C-mFc labeled tag. The total length of PLGF Protein, Human (HEK293, mFc) is 170 a.a., with molecular weight of ~43.7 kDa.

HY-P78783

	*Transferrin R2 Protein, Mouse (HEK293, mFc)* Transferrin R2; TFR2	Mouse	HEK293
	Transferrin R2 Protein is a key player in non-iron dependent cellular uptake of transferrin-bound iron, emphasizing its role in nuanced iron metabolism. Beyond this, it may crucially impact hepatocyte function and erythrocyte differentiation. The specific molecular mechanisms and regulatory impact on iron-related pathways remain to be fully elucidated, necessitating comprehensive studies to understand Transferrin R2's broader implications in cellular and physiological processes. Transferrin R2 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived Transferrin R2 protein, expressed by HEK293, with N-mFc labeled tag. The total length of Transferrin R2 Protein, Mouse (HEK293, mFc) is 696 a.a., with molecular weight of ~116 kDa.

HY-P78890

	*CTLA-4 Protein, Human (Biotinylated, HEK293, mFc-Avi)* CTLA4; CD152	Human	HEK293
	The CTLA-4 protein is a key inhibitory receptor and a major negative regulator of T cell responses in coordination of immune regulation. Its unique property is its significantly increased affinity for B7 ligands (CD80/CD86) compared with CD28. CTLA-4 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived CTLA-4 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of CTLA-4 Protein, Human (Biotinylated, HEK293, mFc-Avi) is 126 a.a., with molecular weight of 50-55 kDa.

HY-P72038

	*SARS-CoV-2 S glycoprotein (HEK293, His-mFc)* Spike glycoproteinRBD; ,Spike Protein RBD;	Virus	HEK293
	The SARS-CoV-2 S glycoprotein is critical in infection, binding to the ACE2 receptor and allowing viral particles to attach to the host cell membrane. Cleavage of S2/S2′ triggers cell membrane fusion or internalization via endocytosis. SARS-CoV-2 S glycoprotein (HEK293, His-mFc) is the recombinant Virus-derived SARS-CoV-2 S glycoprotein, expressed by HEK293 , with C-mFc, C-6*His labeled tag. The total length of SARS-CoV-2 S glycoprotein (HEK293, His-mFc) is 223 a.a., with molecular weight (glycosylation form) of ~66.0 kDa.

HY-P77990

	*LRP-6 Protein, Human (HEK293, mFc)* LRP-6; DCAD2; FLJ90062; FLJ90421	Human	HEK293
	LRP-6 protein is a key component of the Wnt-Fzd-LRP5-LRP6 complex, a component of β-catenin signaling, and is essential for bone formation. LRP-6 acts as a cell surface co-receptor and coordinates the formation of signalosomes by clustering receptor-ligand complexes. LRP-6 Protein, Human (HEK293, mFc) is the recombinant human-derived LRP-6 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of LRP-6 Protein, Human (HEK293, mFc) is 611 a.a., with molecular weight of 100-120 kDa.

HY-P700790

	*MICA Protein, Human (HEK293, mFc)* MICA; MIC-A; MICA alpha 3	Human	HEK293
	MICA is the gene for major histocompatibility complex class I chain-associated protein A, encoding a highly polymorphic cell surface protein. Unlike traditional class I molecules, it lacks beta-2-microglobulin association. MICA Protein, Human (HEK293, mFc) is the recombinant human-derived MICA protein, expressed by HEK293 , with N-mFc labeled tag. The total length of MICA Protein, Human (HEK293, mFc) is 96 a.a., with molecular weight of 50-65 kDa.

HY-P75341

	*CG alpha Protein, Human (HEK293, mFc)* Glycoprotein hormones alpha chain; CG-alpha; FSH-alpha; CGA	Human	HEK293
	The CG alpha protein, a shared alpha chain in glycoprotein hormones (TSH, LH, FSH, CG), binds to receptors, initiating signaling pathways. Heterodimeric hormones involve CG alpha and a specific beta chain (TSHB, LHB, FSHB, CGB), imparting biological specificity. CG alpha Protein, Human (HEK293, mFc) is the recombinant human-derived CG alpha protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CG alpha Protein, Human (HEK293, mFc) is 92 a.a., with molecular weight of ~45.8 kDa.

HY-P75466

	*BTLA/CD272 Protein, Rat (HEK293, mFc)* B- and T-lymphocyte attenuator; CD272; BTLA	Rat	HEK293
	BTLA/CD272 protein inhibits antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. It regulates immune responses through cis and trans interactions with TNFRSF14. In cis, it maintains resting state in naive T cells, while in trans, it supports survival signals in effector T cells. BTLA/CD272 interacts with PTPN6/SHP-1, PTPN11/SHP-2, and TNFRSF14/HVEM. BTLA/CD272 Protein, Rat (HEK293, mFc) is the recombinant rat-derived BTLA/CD272 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of BTLA/CD272 Protein, Rat (HEK293, mFc) is 154 a.a., with molecular weight of ~55-77 kDa.

HY-P78442

	*FGF-21 Protein, Human (HEK293, mFc-Avi)* UNQ3115; PRO10196; FGF-21; FGF21	Human	HEK293
	FGF-21 Proteinas, pivotal in promoting glucose uptake in adipocytes, induces SLC2A1/GLUT1 expression, not affecting SLC2A4/GLUT4, contingent on KLB. It significantly regulates systemic glucose homeostasis and insulin sensitivity, with direct KLB interaction via its C-terminus. Engagement with FGFR4 adds complexity to its molecular mechanisms, highlighting its role in orchestrating cellular responses beyond localized effects. FGF-21 Protein, Human (HEK293, mFc-Avi) is the recombinant human-derived FGF-21 protein, expressed by HEK293 , with N-mFc, N-Avi labeled tag. The total length of FGF-21 Protein, Human (HEK293, mFc-Avi) is 181 a.a., with molecular weight of 52-60 kDa.

HY-P78470

	*IL-23R Protein, Human (HEK293, mFc)* IBD17; IL-23 R; IL-23 receptor	Human	HEK293
	IL-23R Protein, critical in immune response, forms the interleukin-23 receptor by associating with IL12RB1. Binding to IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. IL23, involved in innate and adaptive immunity, contributes to acute infection response. Associated with autoimmune diseases and tumorigenesis, IL-23R, in the presence of IL12RB1, forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. IL-23R Protein, Human (HEK293, mFc) is the recombinant human-derived IL-23R protein, expressed by HEK293, with C-mFc labeled tag. The total length of IL-23R Protein, Human (HEK293, mFc) is 332 a.a., with molecular weight of 80-115 kDa.

HY-P78561

	*CD47 Protein, Human (Biotinylated, HEK293, mFc-Avi)* CD47; MER6; IAP; OA3	Human	HEK293
	FITC-Labeled CD47, an adhesive protein, modulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, impacting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal, and immunoregulation. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor agent in blood pressure regulation, and is crucial for memory formation. CD47's interactions with SIRPA, SIRPG, and FAS/CD95 influence dendritic cell maturation, T-cell activation, apoptosis, and angiogenesis. As a monomer, CD47 intricately participates in diverse cellular and molecular pathways, contributing to physiological and pathological processes. CD47 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived CD47 protein, expressed by HEK293, with C-mFc, C-Avi labeled tag. The total length of CD47 Protein, Human (Biotinylated, HEK293, mFc-Avi) is 121 a.a., with molecular weight of 60-66 kDa.

HY-P700413

	*Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi)* Somatotropin receptor Serum-binding protein	Human	HEK293
	Growth Hormone R (GHR) is the receptor for pituitary growth hormone, crucial in postnatal body growth regulation. Binding to its ligand activates the JAK2/STAT5 pathway, facilitating intracellular signaling. The soluble form, GHBP (Growth Hormone Binding Protein), acts as a growth hormone reservoir in the bloodstream. GHBP may modulate or inhibit growth hormone signaling, contributing to intricate growth process regulation. Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived Growth Hormone R/GHR protein, expressed by HEK293, with C-Avi, C-mFc labeled tag. The total length of Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi) is 238 a.a., with molecular weight of 56.6 kDa.

HY-P78420

	*CD96 Protein, Human (HEK293, mFc)* CD96 molecule; CD96; DKFZp667E2122; TACTILE	Human	HEK293
	CD96 promotes adhesive interactions between activated T cells and NK cells in the late stages of the immune response. It promotes the adhesion between NK cells and target cells by interacting with PVR on target cells. CD96 Protein, Human (HEK293, mFc) is the recombinant human-derived CD96 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CD96 Protein, Human (HEK293, mFc) is 482 a.a., with molecular weight of 120-160 kDa.

HY-P700719

	*FGF-21 Protein, Human (Biotinylated, HEK293, mFc-Avi)* UNQ3115; PRO10196; FGF-21; FGF21	Human	HEK293
	FGF-21 Proteinas, pivotal in promoting glucose uptake in adipocytes, induces SLC2A1/GLUT1 expression, not affecting SLC2A4/GLUT4, contingent on KLB. It significantly regulates systemic glucose homeostasis and insulin sensitivity, with direct KLB interaction via its C-terminus. Engagement with FGFR4 adds complexity to its molecular mechanisms, highlighting its role in orchestrating cellular responses beyond localized effects. FGF-21 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived FGF-21 protein, expressed by HEK293 , with N-Avi, N-mFc labeled tag. The total length of FGF-21 Protein, Human (Biotinylated, HEK293, mFc-Avi) is 181 a.a., with molecular weight of 55-65 kDa.

HY-P78489

	*Mer Protein, Human (HEK293, mFc)* MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12	Human	HEK293
	Mer Protein, a receptor tyrosine kinase, transduces signals by binding ligands like LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (efferocytosis). Ligand binding induces MERTK autophosphorylation, creating docking sites for downstream molecules. Activated by ligand, Mer interacts with GRB2 or PLCG2, inducing MAPK1, MAPK2, FAK/PTK2, or RAC1 phosphorylation. MERTK signaling is implicated in macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment. In the retinal pigment epithelium (RPE), Mer regulates phagocytosis of rod outer segment fragments. Moreover, Mer inhibits Toll-like receptors (TLRs)-mediated innate immune responses by activating STAT1, inducing SOCS1 and SOCS3 production. Mer Protein, Human (HEK293, mFc) is the recombinant human-derived Mer protein, expressed by HEK293, with C-mFc labeled tag. The total length of Mer Protein, Human (HEK293, mFc) is 485 a.a., with molecular weight of 115-140 kDa.

HY-P78589

	*FGL1 Protein, Cynomolgus (HEK293, mFc)* FGL1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1	Cynomolgus	HEK293
	FGL1 Protein, a potent immune suppressive molecule, inhibits antigen-specific T-cell activation as a major ligand for LAG3. It crucially contributes to LAG3-mediated T-cell inhibitory functions, independently of MHC class II. Secreted by hepatocytes, FGL1 also promotes their growth. The homodimeric form of the protein interacts with LAG3, specifically engaging with its Ig-like domains 1 and 2 through the Fibrinogen C-terminal domain. FGL1 Protein, Cynomolgus (HEK293, mFc) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of FGL1 Protein, Cynomolgus (HEK293, mFc) is 290 a.a., with molecular weight of 60-66 kDa.

HY-P75310

	*DAP10 Protein, Human (HEK293, mFc)* Hematopoietic cell signal transducer; HCST; DAP10; KAP10; PIK3AP	Human	HEK293
	DAP10 is a transmembrane adapter protein that forms the activating receptor KLRK1-HCST, which is critical for cytotoxicity in target cells expressing stress-inducing ligands. It is activated by ULBP, triggering calcium mobilization and activating PI3K, MAP2K/ERK and JAK2/STAT5 signaling pathways. DAP10 Protein, Human (HEK293, mFc) is the recombinant human-derived DAP10 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of DAP10 Protein, Human (HEK293, mFc) is 30 a.a., with molecular weight of ~33-45 kDa.

HY-P77235

	*TIGIT Protein, Mouse (HEK293, mFc)* T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3	Mouse	HEK293
	TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TIGIT Protein, Mouse (HEK293, mFc) is 125 a.a., with molecular weight of ~39-52 KDa.

HY-P77622

CD28 Protein, Canine (HEK293, mFc)

CD28 antigen (Tp44); CD28 molecule; CD28; MGC138290
Canine HEK293

HY-P70525

	*PD-1 Protein, Human (HEK293, mFc)* Programmed cell death protein 1; hPD-1; PDCD1; CD279	Human	HEK293
	PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (HEK293, mFc) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of PD-1 Protein, Human (HEK293, mFc) is 147 a.a., with molecular weight of 55-70 kDa.

HY-P78659

	*TSLP Protein, Human (R127A, R130A, HEK293, mFc)* Thymic stromal lymphopoietin; Thymic stroma-derived lymphopoietin; TSLP	Human	HEK293
	TSLP Protein, a cytokine, stimulates T-cell-attracting chemokine release from monocytes and enhances CD11c(+) dendritic cell maturation. It directly activates mast cells, possibly inducing allergic inflammation. TSLP may also possess antimicrobial properties in the oral cavity and on the skin. TSLP Protein, Human (R127A, R130A, HEK293, mFc) is the recombinant human-derived TSLP protein, expressed by HEK293 , with C-mFc labeled tag and R127A, R130A mutation. The total length of TSLP Protein, Human (R127A, R130A, HEK293, mFc) is 131 a.a., with molecular weight of 50-58 kDa.

HY-P74710

Neuregulin-1/NRG1 Protein, Canine (65a.a, HEK293, mFc)

Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1
Canine HEK293

HY-P78536

	*VEGFR-2 Protein, Human (HEK293, mFc)* CD309; KDR; VEGFR; VEGFR2; VEGFR-21; FLK1; KRD1; Ly73	Human	HEK293
	VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Human (HEK293, mFc) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of VEGFR-2 Protein, Human (HEK293, mFc) is 745 a.a., with molecular weight of 150-200 kDa.

HY-P79115

	*Frizzled-9 Protein, Mouse (HEK293, mFc)* Frizzled-9; Fzd9; Fz-9; mFz3; mFz9; CD349; Fzd3	Mouse	HEK293
	Frizzled-9, a WNT2 receptor, crucially activates the beta-catenin pathway, involving disheveled protein activation, GSK-3 kinase inhibition, nuclear beta-catenin accumulation, and Wnt target gene activation. Beyond canonical signaling, it negatively regulates acetylcholine receptor clustering in neuromuscular junction assembly and influences neural progenitor cell viability by regulating the cell cycle. In hippocampal development, Frizzled-9 regulates neuroblast proliferation and apoptosis. Additionally, it plays a pivotal role in bone dynamics, modulating bone formation and regeneration through non-canonical Wnt signaling pathways. Frizzled-9 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived Frizzled-9 protein, expressed by HEK293, with C-mFc labeled tag. The total length of Frizzled-9 Protein, Mouse (HEK293, mFc) is 163 a.a., with molecular weight of 52-61 kDa.

HY-P700428

	*Plexin B1 Protein, Human (HEK293, mFc)* Plexin-B1; PLXNB1; Semaphorin receptor SEP; KIAA0407; PLXN5; SEP	Human	HEK293
	Plexin B1 Protein, a receptor for SEMA4D, crucially influences GABAergic and inhibitory synapse development. It activates RHOA, leading to actin cytoskeleton changes, impacting axon guidance, invasive growth, and cell migration. As a monomer or heterodimer with PLXNB2, Plexin B1 binds activated RAC1 and interacts with various proteins. Its interaction with SEMA4D emphasizes its intricate involvement in cellular signaling pathways and synaptic development. Plexin B1 Protein, Human (HEK293, mFc) is the recombinant human-derived Plexin B1 protein, expressed by HEK293, with N-mFc labeled tag. The total length of Plexin B1 Protein, Human (HEK293, mFc) is 516 a.a., with molecular weight of 83.2 kDa.

HY-P70735

	*LAG-3 Protein, Human (HEK293, mFc)* Lymphocyte activation gene 3 protein; LAG3; LAG-3; Protein FDC; CD223	Human	HEK293
	LAG-3 (lymphocyte activating gene 3) protein is an inhibitory receptor on antigen-activated T cells and is critical for immune regulation. LAG-3 binds to FGL1 and transmits inhibitory signals that negatively affect CD8(+) and CD4(+) T cell proliferation, activation, and effector functions. LAG-3 Protein, Human (HEK293, mFc) is the recombinant human-derived LAG-3 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of LAG-3 Protein, Human (HEK293, mFc) is 428 a.a., with molecular weight of ~90.0 kDa.

HY-P70740

	*FGL1 Protein, Human (HEK293, mFc)* Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, mFc) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGL1 Protein, Human (HEK293, mFc) is 290 a.a., with molecular weight of 60-65 kDa.

HY-P700850

	*VEGFR-2 Protein, Human (Biotinylated, HEK293, mFc)* CD309; KDR; VEGFR; VEGFR2; VEGFR-21; FLK1; KRD1; Ly73	Human	HEK293
	VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Human (Biotinylated, HEK293, mFc) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of VEGFR-2 Protein, Human (Biotinylated, HEK293, mFc) is 745 a.a., with molecular weight of 135-160 kDa.

HY-P71374

	*TPBG/5T4 Protein, Human (HEK293, mFc)* TPBG; 5T4 ; 5T4AG; M6P1; WAIF1	Human	HEK293
	TPBG/5T4 protein acts as an inhibitor of Wnt/β-catenin signaling, possibly by interacting indirectly with LRP6 and hindering Wnt3a-dependent LRP6 internalization. This means that TPBG/5T4 plays a crucial role in regulating the complex Wnt/β-catenin signaling pathway and exerts a regulatory influence on cellular responses related to this pathway. TPBG/5T4 Protein, Human (HEK293, mFc) is the recombinant human-derived TPBG/5T4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TPBG/5T4 Protein, Human (HEK293, mFc) is 324 a.a., with molecular weight of 80-110 kDa.

HY-P78008

	*NKp46/NCR1 Protein, Human (HEK293, mFc)* CD335; Ly94; NCR1; NKp46; MAR-1; NKP46FLJ99094	Human	HEK293
	NKp46/NCR1 protein, a cytotoxicity-activating receptor on natural killer (NK) cells, potentially enhances their efficacy in tumor cell lysis. Interacting with CD247 and FCER1G, NKp46/NCR1 plays a pivotal role in signaling pathways associated with NK cell activation and cytotoxicity. It contributes to the regulatory network for recognizing and eliminating target cells, emphasizing its importance in immune surveillance and anti-tumor responses. NKp46/NCR1 Protein, Human (HEK293, mFc) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of NKp46/NCR1 Protein, Human (HEK293, mFc) is 234 a.a., with molecular weight of 65-75 kDa.

HY-P78404

	*CD24 Protein, Human (HEK293, mFc)* CD 24; CD24 molecule; CD24A; FLJ22950; FLJ43543; MGC75043	Human	HEK293
	The CD24 protein plays a critical role in cellular differentiation in various cell types, and its signaling may be initiated by lectin-like ligands that bind to the CD24 carbohydrate and transduced by second messengers released from GPI anchors. CD24 also regulates B cell activation responses, promoting AG-dependent B cell proliferation and preventing terminal differentiation into antibody-forming cells. CD24 Protein, Human (HEK293, mFc) is the recombinant human-derived CD24 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CD24 Protein, Human (HEK293, mFc) is 33 a.a., with molecular weight of 48-60 kDa.

HY-P70740A

	*FGL1 Protein, Human (HEK293, mFc, solution)* Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, mFc, solution) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGL1 Protein, Human (HEK293, mFc, solution) is 290 a.a., with molecular weight of 60-65 kDa.

HY-P73682

	*RANK L/TNFSF11 Protein, Human (HEK293, mFc)* Tumor necrosis factor ligand superfamily member 11; ODF; RANKL; CD254; TNFSF11	Human	HEK293
	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Human (HEK293, Fc) is a recombinant human RANKL (G63-D244) with N-terminal mFc tag, which is produced in HEK293 cell.

HY-P70325

	*IL-4R alpha/CD124 Protein, Human (HEK293, mFc)* rHuInterleukin-4 receptor subunit alpha/IL-4 RA, MFC; Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding protein; IL4-BP; IL4R; IL4RA	Human	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (M26-Q231) is produced in HEK293 cells with a C-Terminal mFc-tag.

HY-P7434

	*SARS-CoV-2 S1 Protein (HEK293, mFc)* 2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	SARS-CoV-2 S1 Protein (HEK293, mFc) is the recombinant 2019-nCoV S1 protein with C-mFc tag produced in HEK293 cells.

HY-P7443

	*ACE2 Protein, Human (HEK293, mFc)* 1 Publications Verification Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2	Human	HEK293
	ACE2 Protein, Human (HEK293, mFc) is a SARS-CoV-2 receptor. Angiotensin-Converting Enzyme 2 efficiently hydrolyses the potent vasoconstrictor angiotensin II to angiotensin. It is a consequence of this action that ACE2 participates in the renin-angiotensin system.

HY-P73406

	*SARS-CoV-2 S Protein RBD (HEK293, mFc)* 2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S Protein RBD (HEK293, mFc) is the recombinant Virus-derived SARS-CoV-2 S protein RBD, expressed by HEK293 , with C-mFc labeled tag. The total length of SARS-CoV-2 S Protein RBD (HEK293, mFc) is 223 a.a., with molecular weight of ~51.5 kDa.

HY-P78255

	*CD24 Protein, Mouse (27a.a, HEK293, mFc)* CD 24; CD24 molecule; CD24A; FLJ22950; FLJ43543; MGC75043	Mouse	HEK293
	The CD24 protein may coordinate cellular differentiation of various cell types, particularly in early thymocyte development. Activation of its signaling involves binding of a lectin-like ligand to the CD24 carbohydrate, triggering the release of second messengers from GPI anchors. CD24 Protein, Mouse (27a.a, HEK293, mFc) is the recombinant mouse-derived CD24 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CD24 Protein, Mouse (27a.a, HEK293, mFc) is 27 a.a., with molecular weight of 58-62 kDa.

HY-P78411

	*CD52 Protein, Human (HEK293, mFc)* CD52 molecule; CD52; CDW52 antigen (CAMPATH-1 antigen); CDw52; He5; HEL-S-171mP	Human	HEK293
	CD52 Protein potentially plays a role in carrying and orienting carbohydrates, suggesting involvement in cellular processes related to carbohydrate transport. Additionally, CD52 may have a more specific role requiring further investigation. Its versatility in carbohydrate-related functions hints at potential significance in cellular activities, particularly those associated with carbohydrate dynamics. Yet, the specific mechanisms and contexts in which CD52 operates remain areas of exploration. CD52 Protein, Human (HEK293, mFc) is the recombinant human-derived CD52 protein, expressed by HEK293, with C-mFc labeled tag. The total length of CD52 Protein, Human (HEK293, mFc) is 12 a.a., with molecular weight of 38-48 kDa.

HY-P70827

	*BCMA/TNFRSF17 Protein, Human (HEK293, mFc)* Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; Tnfrsf17; Bcm; Bcma	Human	HEK293
	B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is used as a biomarker for Multiple myeloma (MM). BCMA mainly plays an important role in B cells for their proliferation, survival and also differentiates them into plasma cells. BCMA/TNFRSF17 Protein, Human (HEK293, mFc) is a recombinant protein with a C-Terminal Fc label, It consists of 54 amino acids (M1-A54) and is produced in HEK293 cells.

HY-P77804

	*NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc)* CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94	Human	HEK293
	NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with C-mFc labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc), has molecular weight of 70-90 kDa.

HY-P77808

NKG2A-CD94 Heterodimer Protein, Mouse (HEK293, mFc)

CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94
Mouse HEK293

HY-P700863

	*DKK1 Protein, Human (89a.a, HEK293, mFc)* Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK1 Protein, Human (89a.a, HEK293, mFc) is the recombinant human-derived DKK1 protein, expressed by HEK293, with C-mFc labeled tag. The total length of DKK1 Protein, Human (89a.a, HEK293, mFc) is 89 a.a., with molecular weight of 45-53 kDa.

HY-P7432

	*SARS-CoV-2 S protein RBD-SD1 (HEK293, mFc)* 2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	SARS-CoV-2 S protein RBD-SD1 (HEK293, mFc) produced in HEK293 cells is a recombinant 2019-nCoV S protein receptor-binding domain (RBD) to conserved subdomains SD1 fragment with C-mFc tag.

HY-P72950

	*CSF1R Protein, Human (HEK293, mFc)* Macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS	Human	HEK293
	CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (HEK293, mFc) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CSF1R Protein, Human (HEK293, mFc) is 498 a.a., with molecular weight of ~81.5 kDa.

HY-P78517

	*CRACC/SLAMF7 Protein, Human (HEK293, mFc)* CD2 subset 1; CRACC; Novel Ly9; CD319; SLAMF7; CS1; 19A; FOAP-12	Human	HEK293
	The CRACC/SLAMF7 protein is an autoligand receptor in the SLAM family that complexly regulates immune cell activation and differentiation through finely regulated interactions. Isoform 1 mediates NK cell activation through an SH2D1A-independent ERK-mediated pathway and positively regulates NK cell function dependent on phosphorylated SH2D1B. CRACC/SLAMF7 Protein, Human (HEK293, mFc) is the recombinant human-derived CRACC/SLAMF7 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CRACC/SLAMF7 Protein, Human (HEK293, mFc) is 204 a.a., with molecular weight of 68-72 kDa.

HY-P700455

	*ACE2 Protein, Human (Biotinylated, HEK293, mFc-Avi)* Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2	Human	HEK293
	The ACE2 protein is an important regulator of blood volume and cardiovascular homeostasis. ACE2 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived ACE2 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of ACE2 Protein, Human (Biotinylated, HEK293, mFc-Avi) is 723 a.a., with molecular weight of 114.9 kDa.

HY-P71248

	*PVRIG Protein, Human (HEK293, mFc)* C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463	Human	HEK293
	The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (HEK293, mFc) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-mFc labeled tag. The total length of PVRIG Protein, Human (HEK293, mFc) is 131 a.a., with molecular weight of 45-55 kDa.

HY-P78400

	*PVR/CD155 Protein, Human (HEK293, mFc)* CD155; HVED; NECL5; Necl-5; nectin-like 5; PVR; PVS; Tage4; PVSFLJ25946; FLJ25946	Human	HEK293
	PVR/CD155 Protein plays a pivotal role in initiating natural killer (NK) cell effector functions by binding CD96 and CD226 receptors. These interactions form a mature immunological synapse, triggering adhesion, lytic granule secretion, interferon-gamma (IFN-gamma), and cytotoxicity in activated NK cells. PVR/CD155 facilitates NK cell-target cell modular exchange and PVR transfer, crucial in tumor cells. However, in tumors, this transfer may induce fratricide NK cell activation, allowing immune evasion. Additionally, PVR/CD155 is implicated in tumor cell invasion and migration. In microbial infections, it acts as a poliovirus receptor, potentially mediating axonal transport through interaction with DYNLT1. PVR/CD155 Protein, Human (HEK293, mFc) is the recombinant human-derived PVR/CD155 protein, expressed by HEK293, with C-mFc labeled tag. The total length of PVR/CD155 Protein, Human (HEK293, mFc) is 323 a.a., with molecular weight of 75-100 kDa.

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