CD24 Protein, Human (HEK293, mFc)
Based on 1 Customer Validation
The CD24 protein plays a critical role in cellular differentiation in various cell types, and its signaling may be initiated by lectin-like ligands that bind to the CD24 carbohydrate and transduced by second messengers released from GPI anchors. CD24 also regulates B cell activation responses, promoting AG-dependent B cell proliferation and preventing terminal differentiation into antibody-forming cells. CD24 Protein, Human (HEK293, mFc) is the recombinant human-derived CD24 protein, expressed by HEK293 , with C-mFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The CD24 protein plays a critical role in cellular differentiation in various cell types, and its signaling may be initiated by lectin-like ligands that bind to the CD24 carbohydrate and transduced by second messengers released from GPI anchors. CD24 also regulates B cell activation responses, promoting AG-dependent B cell proliferation and preventing terminal differentiation into antibody-forming cells. CD24 Protein, Human (HEK293, mFc) is the recombinant human-derived CD24 protein, expressed by HEK293 , with C-mFc labeled tag.
The CD24 protein is implicated in playing a pivotal role in the cell differentiation of various cell types, with its signaling potentially triggered by the binding of a lectin-like ligand to CD24 carbohydrates, transduced through the release of second messengers derived from the GPI-anchor. CD24 also functions in modulating B-cell activation responses, promoting AG-dependent proliferation of B-cells, and preventing their terminal differentiation into antibody-forming cells. In association with SIGLEC10, CD24 may contribute to the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70, and HSP90, suggesting a role in immune regulation. Additionally, CD24 is implicated in the control of autoimmunity. It exhibits cell-type-specific interactions with LYN and FGR, binding to FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562, and in Burkitt's lymphoma, highlighting its diverse involvement in cellular processes and immune regulation.
Immobilized Human CD24, mFc Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-CD24 Antibody, hFc Tag with the EC50 of ≤0.20 μg/mL determined by ELISA.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-mFc
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Accession
P25063-1 (S27-G59)
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Molecular Construction
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N-term
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CD24 (S27-G59)
Accession # P25063-1 -
mFc
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C-term
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Protein Length
Full Length of Isoform-1 Mature Peptide
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Synonyms
CD24; Signal Transducer CD24; CD24 Molecule; Small Cell Lung Carcinoma Cluster 4 Antigen; CD24A; CD24 Antigen; CD24 Antigen (Small Cell Lung Carcinoma Cluster 4 Antigen)
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AA Sequence
SETTTGTSSNSSQSTSNSGLAPNPTNATTKAAG
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Predicted Molecular Mass
29.5 kDa
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Molecular Weight
Approximately 48-60 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 5% trehalose.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (235 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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