CD24 - CD24 molecule Gene

Also Known as CD24A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 100133941

About CD24

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:106,969,831-106,976,855 (from NCBI)

This gene has 8 transcripts (splice variants), 152 orthologues and is associated with 1 phenotype. Biased expression in thyroid (RPKM 586.8), esophagus (RPKM 431.3) and 12 other tissues.

Summary

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

CD24 Products (5)

mRNA	Protein	Name
NM_001291737.1	NP_001278666.1	signal transducer CD24 isoform a preproprotein
NM_001291738.1	NP_001278667.1	signal transducer CD24 isoform a preproprotein
NM_001291739.1	NP_001278668.1	signal transducer CD24 isoform b
NM_001359084.1	NP_001346013.1	signal transducer CD24 isoform a preproprotein
NM_013230.3	NP_037362.1	signal transducer CD24 isoform a preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8753773	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8753773	GOA
enables protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	11313396	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor transport into membrane raft	IDA IDA: Inferred from direct assay	11313396	GOA
involved in T cell costimulation	IDA IDA: Inferred from direct assay	11272271	GOA
involved in cell activation	IDA IDA: Inferred from direct assay	8223854	GOA
involved in glomerular parietal epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	19092120	GOA
involved in negative regulation of transforming growth factor beta3 production	IMP IMP: Inferred from mutant phenotype	16930538	GOA
involved in podocyte differentiation	IMP IMP: Inferred from mutant phenotype	19092120	GOA
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	12496407	GOA
involved in positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	11272271	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	2153173	GOA
involved in positive regulation of nephron tubule epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16885410	GOA
involved in regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11313396	GOA
involved in regulation of phosphorylation	IDA IDA: Inferred from direct assay	11313396	GOA
involved in respiratory burst	IDA IDA: Inferred from direct assay	8223854	GOA
involved in response to estrogen	IEP IEP: Inferred from expression pattern	10037815	GOA
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15174142	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	16532032	GOA
located in membrane	IDA IDA: Inferred from direct assay	10037815	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	11313396	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD24 Protein Structure

CD24

0
80 a.a.

Protein Preferred Names	Protein Names
signal transducer CD24	CD24 antigen (small cell lung carcinoma cluster 4 antigen)

CD24 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD24	P25063	LYN	Homo sapiens	P07948	Anti Bait CoIP	22731636

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD24 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70720	CD24 Protein, Human (S44T, HEK293, Fc)	P25063-1 (S27-G59, S44T)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70809	CD24 Protein, Human (HEK293, Fc)	P25063-1 (S27-G59)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72352	CD24 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P25063-1 (S27-G59)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78088	CD24 Protein, Human (Biotinylated, HEK293, mFc)	P25063-1 (S27-G59)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78404	CD24 Protein, Human (HEK293, mFc)	P25063-1 (S27-G59)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78544	CD24 Protein-VLP, Human (HEK293)	P25063-1 (S27-G59)	Purity analysis by SDS-PAGE is not available for VLP proteins.
HY-P78913	CD24 Protein, Human (Biotinylated, HEK293, His-Avi)	P25063-1 (S27-G59)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700401	CD24 Protein-Nanoparticle, Human (HEK293, His)	P25063-1 (S27-G59)	≥ 95%, as determined by reducing SDS-PAGE.

CD24 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86803	CD24 Antibody (YA6496)	ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Erythroleukemia
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Breast Carcinoma In Situ	Carcinoma In Situ Of Breast Non-Infiltrating Carcinoma Of Breast Breast Cancer In Situ
Ductal Carcinoma In Situ	Noninfiltrating Intraductal Carcinoma
In Situ Carcinoma	Carcinoma In Situ
Colorectal Cancer, Hereditary Nonpolyposis, Type 8	HNPCC8 Hereditary Nonpolyposis Colorectal Cancer Type 8 Hereditary Non-Polyposis Colorectal Cancer 8 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 8
Pre-Malignant Neoplasm
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Bronchiectasis 1
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10091	CD24/Siglec-10 blocking peptide, CSBP	Inhibitor	99.12%	Unkown
HY-156816	ON 108600	Inhibitor	98.65%	Unkown
HY-100914	A-7 hydrochloride	Antagonist	99.09%	Unkown
HY-169262	PLD-IN-1		99.18%	Unkown
HY-N19791	6-Methoxymellein	Inhibitor	97.69%	Unkown
HY-RS02212	CD24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-128795	KH176m	Inhibitor	/	Unkown
HY-164480	GTCpFE	Inhibitor	/	Unkown
HY-N15201	Betavulgarin	Inhibitor	/	Unkown
HY-RS23018	Cd24 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990282	Anti-Mouse CD24 Antibody (M1/69)	Inhibitor	≥95.0%	Unkown
HY-P991196	Anti-CD24 Antibody (SWA11)	Inhibitor	99.18%	Unkown
HY-P99928	Efprezimod alfa		99.25%	Unkown
HY-P992303	Anti-Siglec-10/CD24 Antibody		/	Unkown
HY-P992441	PHST001	Inhibitor	/	Unkown
HY-P992443	PP6373 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD24	VGNC	VGNC:27014
Mus musculus	CD24	MGD	MGI:88323
Rattus norvegicus	CD24	RGD	RGD:2298