Betavulgarin
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44+/CD24− subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling.
For research use only. We do not sell to patients.
- CAS No.: 51068-94-1
- Formula: C17H12O6
- Molecular Weight:312.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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p-STAT3 |
Betavulgarin (50-500 μM, 24 h) significantly suppresses the proliferation, migration, colony formation, and mammosphere formation of MDA-MB-231 cells, MCF-7 cells[1].
Betavulgarin (200 μM, 24 h) reduces the size of the CD44+/CD24− subpopulation with the cell fraction from 90.4% to 57.2% in MDA-MB-231 cells[1].
Betavulgarin (200 μM, 48 h) inhibits the translocation of Stat3 and decreases the total protein level and nuclear protein level of p-Stat3 as well as the mRNA and protein levels of SOX2 in MDA-MB-231-derived mammospheres[1].
Betavulgarin (200 μM, 48 h) significantly inhibits the DNA-binding capacity of Stat3 in MDA-MB-231-derived mammosphere[1].
Betavulgarin (24-72 h) reduces the mRNA expression of the self-renewal- related genes, C-Myc, Nanog, and Oct4 in BCSCs-derived mammospheres, and inhibits mammosphere growth[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells, MCF-7 cells
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Concentration:50, 100, 200, 300, 400, 500 μM
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Incubation Time:24 h
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Result:Suppressed the proliferation of MDA-MB-231 and MCF-7 cells at ≥ 100 µM and 50 µM, respectively.
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Cell Line:MDA-MB-231 cells, MCF-7 cells
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Concentration:100 μM
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Incubation Time:24 h
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Result:Inhibited migration of MDA-MB-231 and MCF-7 cells.
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Cell Line:MDA-MB-231 cells, MCF-7 cells
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Concentration:200 μM
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Incubation Time:48 h
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Result:Inhibited the translocation of Stat3, and significantly decreased the total protein levels and nuclear protein level of Stat3 and p-Stat3, as well as the protein levels of SOX2 in MDA-MB-231-derived mammospheres.
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Cell Line:MDA-MB-231 cells, MCF-7 cells
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Concentration:200 μM
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Incubation Time:48 h
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Result:Reduced the level of nuclear pStat3 in MDA-MB-231 cells.
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Cell Line:MDA-MB-231 cells
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Concentration:200 μM
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Incubation Time:48 h
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Result:Reduced the mRNA level of SOX2 in MDA-MB-231-derived mammospheres.
Chemical Information
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CAS No. 51068-94-1
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Molecular Weight 312.27
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Formula C17H12O6
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SMILES
O=C1C(C2=C(O)C=CC=C2)=COC3=C1C(OC)=C4OCOC4=C3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Betavulgarin Related Classifications
HY-N15201 Related Classifications
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