Antifungal agent 41
Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections.
For research use only. We do not sell to patients.
- CAS No.: 3033703-21-5
- Formula: C22H18Cl4N4Se2
- Molecular Weight:638.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
32.53 μM
Compound: B01
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Cytotoxicity against human HL-60 cells by MTT assay
Cytotoxicity against human HL-60 cells by MTT assay
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[PMID: 36057236] |
| MDA-MB-231 | IC50 |
6.25 μM
Compound: B01
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Cytotoxicity against human MDA-MB-231 cells by MTT assay
Cytotoxicity against human MDA-MB-231 cells by MTT assay
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[PMID: 36057236] |
| PC-3 | IC50 |
1.43 μM
Compound: B01
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Cytotoxicity against human PC-3 cells by MTT assay
Cytotoxicity against human PC-3 cells by MTT assay
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[PMID: 36057236] |
Antifungal agent 41 (0.25-128 μg/mL) shows antifungal activities to C.alb, C.alb (sc5314), C.gla, C.par, C.kru, C.zey, C.neo and A.f with MIC values of 2, 1, 8, 2, 8, 0.25, 4 and 1 μg/mL, respectively[1]. Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against pathogenic fluconazole-resistant Candida albicans with MIC values of 2, 8, 4, 2 and 4 μg/mL for strain CaR, 17#, 632, 901 and 904, respectively[1]. Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against Candida albicans with MFC value of 16, 8, 16, >64, 16, 2 and 4 μg/mL for C.alb, C.alb (sc5314), strain CaR, 17#, 632, 901 and 904, respectively[1]. Antifungal agent 41 (0-1024 μg/mL; 1.5-24 h) inhibits C.alb ATCC SC5314 and CPCC400616 biofilms with SMIC50s of 0.5 μg/mL and 0.5-4 μg/mL, with SMIC80s of 4-32 μg/mL and 2-4 μg/mL, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60, MDA-MB-231 and PC-3 cell lines
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Inhibited growth of HL-60, MDA-MB-231 and PC-3 cells with IC50s of 32.53, 6.25 and 1.43 μM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with C.alb ATCC SC5314 infection[1]
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Dosage:6 mg/kg and 12 mg/kg
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Administration:Intraperitoneal injection; 6 mg/kg and 12mg/kg once daily; for 5 days
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Result:Significantly reduced the kidney fungal burden of C.alb.
Chemical Information
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CAS No. 3033703-21-5
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Molecular Weight 638.14
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Formula C22H18Cl4N4Se2
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SMILES
ClC1=CC=C(C([Se][Se]C(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)CN4C=CN=C4)C(Cl)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antifungal agent 41 Related Classifications
HY-151439 Related Classifications
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