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Pathways Recommended: Membrane Transporter/Ion Channel
Results for "

fungal membranes

" in MedChemExpress (MCE) Product Catalog:

68

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2

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4

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2

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8

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13

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5

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1

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0221
    Amphotericin B
    Maximum Cited Publications
    26 Publications Verification

    		 Fungal Antibiotic Bacterial Parasite Infection Cancer
    Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
    Amphotericin B
  • HY-111391
    Resazurin sodium
    5 Publications Verification

    Diazoresorcinol sodium

    		 Bacterial Fluorescent Dye Infection
    Resazurin sodium (Diazoresorcinol sodium) is a non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin sodium is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin sodium can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .
    Resazurin sodium
  • HY-B0133
    Natamycin
    5+ Cited Publications

    Pimaricin

    		 Environmental Pollutants Antibiotic Endogenous Metabolite Fungal Bacterial Infection
    Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research .
    Natamycin
  • HY-14273
    Isavuconazole
    5 Publications Verification

    BAL-4815; RO-0094815

    		 Fungal Cytochrome P450 Antibiotic Infection Cancer
    Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
    Isavuconazole
  • HY-129555
    Surfactin
    5+ Cited Publications

    		 Bacterial HSV Antibiotic Infection
    Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects . Surfactin also has antiviral activity against a variety of enveloped viruses .
    Surfactin
  • HY-111391A
    Resazurin sodium, indicator

    Diazoresorcinol sodium, indicator

    		 Bacterial Fluorescent Dye Others
    Resazurin (Diazoresorcinol) sodium, indicator is a non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin sodium, indicator is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin sodium, indicator can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .
    Resazurin sodium, indicator
  • HY-119847
    Abafungin

    BAY-W-6341

    		 Fungal Infection
    Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses .
    Abafungin
  • HY-W020246
    Tetramethylthiuram monosulfide

    TMTM

    		 Squalene Monooxygenase Bacterial Infection Inflammation/Immunology
    Tetramethylthiuram monosulfide (TMTM) is an orally active microsomal monooxygenases inhibitor. Tetramethylthiuram monosulfide is used as an accelerator and activator in the processing of natural rubber and butyl rubber. Tetramethylthiuram monosulfide reduces palmitic acid incorporation into microsomal phospholipids, disrupts microsomal membrane integrity, and impairs electron transport during oxygenation. Tetramethylthiuram monosulfide can be used for the research of fungal infection, bacterial infection and allergic contact dermatitis .
    Tetramethylthiuram monosulfide
  • HY-118540
    Resazurin

    Diazoresorcinol

    		 Fluorescent Dye Bacterial Infection
    Resazurin (Diazoresorcinol) is a water-soluble, non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .
    Resazurin
  • HY-W250308A
    ε-Poly-L-lysine hydrochloride (MV 2000-5000)

    Epsilon-polylysine hydrochloride (MV 2000-5000); ε-Polylysine hydrochloride (MV 2000-5000); ε-PL hydrochloride (MV 2000-5000)

    		 Bacterial Fungal Reactive Oxygen Species (ROS) Infection
    ε-Poly-L-lysine (Epsilon-polylysine; ε-Polylysine) hydrochloride (MV 2000-5000) is a polycationic antibacterial agent with broad-spectrum activity against Gram-positive bacteria, Gram-negative bacteria, fungi, yeasts and specific bacteriophages. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exerts bactericidal effects through mechanisms such as disrupting microbial membranes, inducing ROS production, inhibiting metabolism and spore germination. ε-Poly-L-lysine hydrochloride (MV 2000-5000) also regulates the expression of multiple key genes including sodA, oxyR and recA. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits properties such as low eukaryotic cytotoxicity, thermal stability and pH stability, and supports tissue regeneration and anti-tumor applications. ε-Poly-L-lysine hydrochloride (MV 2000-5000) can be applied in research fields including bacterial and fungal infections, diabetic ulcers, and methicillin-resistant Staphylococcus aureus infections .
    ε-Poly-L-lysine hydrochloride (MV 2000-5000)
  • HY-126810A
    NP213 TFA

    		Fungal Infection
    NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .
    NP213 TFA
  • HY-109040
    Quilseconazole

    VT-1129

    		 Fungal Cytochrome P450 Infection Inflammation/Immunology
    Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases .
    Quilseconazole
  • HY-14282
    Lanoconazole
    1 Publications Verification

    		 Fungal Infection Inflammation/Immunology
    Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi?in vitro?and?in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
    Lanoconazole
  • HY-P4809
    Polybia-MP1

    		Bacterial Fungal Infection Cancer
    Polybia-MP1 is an antimicrobial peptide with antibacterial, antifungal and anticancer activities. Polybia-MP1 selectively targets cancer cells by interacting with PS and PE in the outer leaflet of cell membranes, and induces necrosis via pore formation. Polybia-MP1 exhibits antibacterial activity against Pseudomonas aeruginosa. Polybia-MP1 can be used in research related to bacterial infections, fungal infections and cancers .
    Polybia-MP1
  • HY-DY1051
    Resazurin sodium (solution)

    		Bacterial Fluorescent Dye Infection
    Resazurin sodium (Diazoresorcinol sodium) (solution) is a non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin sodium is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin sodium can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .
    Solvent and Concentration: Sterile water: 10 mM
    Resazurin sodium (solution)
  • HY-117089
    Tetraconazole

    		Environmental Pollutants Fungal Infection
    Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells .
    Tetraconazole
  • HY-126810
    NP213

    		Fungal Infection
    NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections .
    NP213
  • HY-163462
    Poacic acid

    		Fungal Infection
    Poacic Acid is a plant-derived stilbenoid with an antifungal activity. Poacic Acid localizes to the yeast cell wall and disrupts the production and assembly of β-1,3-glucan in the fungal cell walls. Poacic Acid exhibits fungicidal activity to Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants .
    Poacic acid
  • HY-14273R
    Isavuconazole (Standard)

    BAL-4815 (Standard); RO-0094815 (Standard)

    		 Reference Standards Fungal Cytochrome P450 Antibiotic Infection
    Isavuconazole (Standard) is the analytical standard of Isavuconazole. This product is intended for research and analytical applications. Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
    Isavuconazole (Standard)
  • HY-N3344
    Macrocarpal C

    		Fungal Others
    Macrocarpal C can be isolated from the 95 % ethanol extract of fresh leaves of E. globulus. Macrocarpal C inhibits the growth of T. mentagrophytes via an increase in the permeability of the fungal membrane. Macrocarpal C increases the production of intracellular ROS and? induces apoptosis as a consequence of DNA fragmentation .
    Macrocarpal C
  • HY-B0133R
    Natamycin (Standard)

    Pimaricin (Standard)

    		 Reference Standards Fungal Endogenous Metabolite Antibiotic Bacterial Infection
    Natamycin (Standard) is the analytical standard of Natamycin. This product is intended for research and analytical applications. Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research .
    Natamycin (Standard)
  • HY-P5640
    Tritrpticin

    		Bacterial Parasite Infection
    Tritrpticin is a porcine-derived antimicrobial peptide with properties such as membrane disruption and hemolysis. Tritrpticin disrupts the cell membranes of bacteria, fungi and Jurkat T cell leukemia cells and induces their death. Tritrpticin also enhances the efficacy of Metronidazole (HY-B0318) against *Trichomonas vaginalis*, reduces plasma endotoxin and inflammatory cytokine levels, restricts bacterial growth in blood and visceral tissues, decreases the mortality rate of septic shock in rats and enhances the therapeutic effect of ertapenem. Tritrpticin exhibits selective cytotoxicity against Jurkat T cell leukemia cells, while showing low toxicity to normal peripheral blood mononuclear cells and red blood cells, and can serve as a template for antimicrobial peptide design. Tritrpticin can be applied to research related to bacterial infections, fungal infections, trichomoniasis, septic shock and leukemia .
    Tritrpticin
  • HY-114518
    Butenafine

    KP363

    		 Fungal Infection
    Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as  tinea pedis,  tinea cruris, tinea versicolor .
    Butenafine
  • HY-N16375
    (3R,6S)-Bassiatin

    		Drug Metabolite Fungal ATP Synthase Infection
    (3R,6S)-Bassiatin (Compound 5) is an enantiomer of the fungal metabolite Bassiatin (HY-165143). Bassianin is a compound isolated from fungi that has the activity of inhibiting erythrocyte membrane ATPase and causing cell lysis. Its inhibitory effect on ATPase may be due to membrane disruption .
    (3R,6S)-Bassiatin
  • HY-14282A
    (Z)-Lanoconazole

    		Fungal Infection Inflammation/Immunology
    (Z)-Lanoconazole is the Z configuration of Lanoconazole. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
    (Z)-Lanoconazole
  • HY-W017611
    4-Propylphenol

    		Environmental Pollutants Reactive Oxygen Species (ROS) Fungal DNA/RNA Synthesis Infection
    4-Propylphenol is a plant-derived phenolic compound. 4-Propylphenol causes an increase in ROS within the Fusarium graminearum cells, leading to damage to the DNA and cell membranes of the mycelia, effectively inhibiting the growth of the mycelia. 4-Propylphenol also has a growth inhibitory effect on walnut pathogenic fungi (C. gloeosporioides, C. siamense, A. alternata), with its EC50 ranging from 29.11 to 31.89 mg/L, and it also inhibits spore germination, with EC50 being 55.04-71.85 mg/L. 4-Propylphenol can be used in the research of fungal diseases in walnuts and wheat Fusarium head blight .
    4-Propylphenol
  • HY-N11546
    Sapindoside B

    		Cytochrome P450 Bacterial Fungal Infection Cancer
    Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases bacterial adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold .
    Sapindoside B
  • HY-171796
    Bromomonilicin

    		Fungal Infection
    Bromomonilicin is a selective fungal cell membrane inhibitor. Bromomonilicin exerts antifungal activity by disrupting fungal cell membrane integrity. Bromomonilicin is promising for research of plant pathogenic fungal infections (e.g., Monilinia fructicola-induced brown rot) and superficial mycoses (e.g., dermatophyte infections) .
    Bromomonilicin
  • HY-P3384
    Pezadeftide

    		Fungal Others Inflammation/Immunology
    Pezadeftide is a potent antifungal peptide. Pezadeftide can enter fungal cells and cause a rapid mitochondrial response that results in hyperpolarization of the mitochondrial membrane .
    Pezadeftide
  • HY-159666
    Nystatin A1

    		Antibiotic Fungal Infection
    Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi .
    Nystatin A1
  • HY-B0221R
    Amphotericin B (Standard)

    		Reference Standards Fungal Antibiotic Bacterial Parasite Infection Cancer
    Amphotericin B (Standard) is the analytical standard of Amphotericin B. This product is intended for research and analytical applications. Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
    Amphotericin B (Standard)
  • HY-177849
    Liposomal Amphotericin B

    Amphotericin B liposome

    		 Liposome Fungal Antibiotic Infection
    Liposomal Amphotericin B is a liposome-encapsulated form of Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. Amphotericin B binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. Liposomal Amphotericin B can significantly reduce the toxicity of Amphotericin B.
    Liposomal Amphotericin B
  • HY-161457
    (Gly0.8Nap0.2)20

    		Fungal DNA/RNA Synthesis Infection
    (Gly0.8Nap0.2)20 is a compound that dual targets fungal membranes and DNA. (Gly0.8Nap0.2)20 has antibacterial activity .
    (Gly0.8Nap0.2)20
  • HY-172804
    SDH-IN-26

    		Succinate Dehydrogenase Fungal Apoptosis Infection
    SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor. SDH-IN-26 exhibits significant inhibitory activity against multiple phytopathogenic fungi, such as Rhizoctonia solani and Botrytis cinerea, with an EC50 value of 0.270 μg/mL against Rhizoctonia solani. SDH-IN-26 damages the integrity of the fungal cell membrane, increases membrane permeability, disrupts cell structure, and reduces the number of mitochondria, thus affecting the normal growth of mycelia. SDH-IN-26 leads to a decrease in mitochondrial membrane potential, and induces cell apoptosis. SDH-IN-26 is promising for research of plant diseases caused by fungi .
    SDH-IN-26
  • HY-W422288
    (Rac)-Ketoconazole

    (Rac)-Ketoconazol; (Rac)-R 41400

    		 Fungal Cytochrome P450 Infection
    (Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections .
    (Rac)-Ketoconazole
  • HY-N11506
    lsocryptomerin

    		Fungal Bacterial Infection Cancer
    lsocryptomerin is a membrane-active antifungal compound that can be isolated from Selaginella tamariscina. lsocryptomerin can depolarize fungal plasma membrane. lsocryptomerin also shows anticancer and antibacterial activities .
    lsocryptomerin
  • HY-176746
    CMLD009688

    		Fungal Infection
    CMLD009688 is a cationic amphiphilic antifungal agent. CMLD009688 selectively inhibits plant pathogenic fungi such as Fusarium graminearum. CMLD009688 interacts with biological membranes, perturbing vacuolar and mitochondrial membrane structures to induce fungal cell death. CMLD009688 is promising for research of plant fungal diseases (e.g., wheat head blight, gray mold) .
    CMLD009688
  • HY-135438
    Mollugogenol A

    		Fungal Infection
    Mollugogenol A is a fungal inhibitor. Mollugogenol A can cause damage to sperm membranes by increasing lipid peroxidation, exhibiting sperm-killing activity .
    Mollugogenol A
  • HY-P11021
    ToAP2

    		Fungal Antibiotic Infection
    ToAP2 is a potent antimicrobial peptide. ToAP2 affects C. albicans membrane permeability and produces changes in fungal cell morphology .
    ToAP2
  • HY-P11021A
    ToAP2 TFA

    		Fungal Antibiotic Infection
    ToAP2 TFA is a potent antimicrobial peptide. ToAP2 TFA affects C. albicans membrane permeability and produces changes in fungal cell morphology .
    ToAP2 TFA
  • HY-114518S2
    Butenafine-d4

    KP363-d4

    		 Fungal Isotope-Labeled Compounds Infection
    Butenafine-d4 (KP363-d4) is the deuterium labeled Butenafine (HY-114518). Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as ?tinea pedis, ?tinea cruris, tinea versicolor .
    Butenafine-d4
  • HY-156281
    Antifungal agent 76

    		Fungal Infection
    Antifungal agent 76 (compound 23h) exhibits potent activities and a broad antifungal spectrum with low MICs of 0.25-16 μg/mL. Antifungal agent 76 might achieve its rapid fungicidal activity by disrupting the fungal cell membrane .
    Antifungal agent 76
  • HY-174394S
    CYP51-IN-25

    		Isotope-Labeled Compounds Fungal Cytochrome P450 Infection
    CYP51-IN-25 is a orally active broad spectrum antifungal agent with the MIC80 of 0.00625-0.05 μg/mL. is a CYP51-IN-25 is a deuterated compound with antibiotic properties. CYP51-IN-25 can inhibit the fungal CYP51 enzyme, block ergosterol synthesis, and disrupt cell membrane integrity. CYP51-IN-25 can be used for research on fungal infections.
    CYP51-IN-25
  • HY-155279
    Antifungal agent 73

    		Fungal Infection
    Antifungal agent 73 (compound A32) is an antifungal agent for azole-resistant candidiasis. Antifungal agent 73 disrupts the fungal cell wall and cell membrane. Antifungal agent 73 shows potent in vivo antifungal activity against pathogenic fungi and fluconazole-resistant strains .
    Antifungal agent 73
  • HY-109040R
    Quilseconazole (Standard)

    VT-1129 (Standard)

    		 Fungal Cytochrome P450 Reference Standards Infection Neurological Disease Inflammation/Immunology
    Quilseconazole (Standard) is the analytical standard of Quilseconazole (HY-109040). This product is intended for research and analytical applications. Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases .
    Quilseconazole (Standard)
  • HY-179250
    LEX-SQ01

    		Fungal Infection
    LEX-SQ01 (Compound D10) is an antifungal agent. LEX-SQ01 shows an EC50 of 1.6 μM for C. capsici. LEX-SQ01 can disrupt the cell membrane integrity of fungal. LEX-SQ01 can be used for the research of infection in crops .
    LEX-SQ01
  • HY-14282R
    Lanoconazole (Standard)

    		Reference Standards Fungal Infection Inflammation/Immunology
    Lanoconazole (Standard) is the analytical standard of Lanoconazole. This product is intended for research and analytical applications. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
    Lanoconazole (Standard)
  • HY-144632
    Antifungal agent 22

    		Fungal Infection
    Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity .
    Antifungal agent 22
  • HY-178340
    Antifungal agent 137

    		Cytochrome P450 Fungal Reactive Oxygen Species (ROS) Infection
    Antifungal agent 137 (Compound 4S) is an antifungal agent. Antifungal agent 137 inhibits Phomopsis sp. (PS), with an EC50 of 0.15 μg/mL. Antifungal agent 137 inhibits lanosterol 14α-demethylase (CYP51), with an IC50 of 5.00 μg/mL. Antifungal agent 137 disrupts the morphology of PS mycelia, impairs cell membrane integrity, and induces an increase in intracellular ROS levels, triggering oxidative stress. Antifungal agent 137 can be used for the study of fungal infection .
    Antifungal agent 137
  • HY-172363
    Succinate dehydrogenase-IN-6

    		Succinate Dehydrogenase Fungal Infection
    Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC50 of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC50s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC50 > 12.5 μg/mL) .
    Succinate dehydrogenase-IN-6

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