Antifungal agent 160
Antifungal agent 160 is a cytochrome bc1 complex inhibitor with activity against Alternaria solani, Gibberella zeae, Colletotrichum gloeosporioides, and Fusarium oxysporum f. sp. melonis. Antifungal agent 160 impairs ATP synthesis, suppresses ATPase activity, induces ROS bursts, compromises plasma membrane integrity, and suppresses fungal growth. Antifungal agent 160 can be used for the research of fungal infection.
For research use only. We do not sell to patients.
- CAS No.: 3103869-13-9
- Formula: C20H21ClN2O5
- Molecular Weight:404.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antifungal agent 160 (compound G2) potently inhibits mycelial growth of Alternaria solani (EC50 = 0.05 μg/mL), Gibberella zeae (EC50 = 6.80 μg/mL), Verticillium dahliae (EC50 = 21.45 μg/mL), Colletotrichum gloeosporioides (EC50 = 17.37 μg/mL), Fusarium oxysporum f. sp. melonis (EC50 = 21.33 μg/mL), and Sclerotinia sclerotiorum (EC50 = 12.75 μg/mL)[1].
Antifungal agent 160 (24 h) exhibits low cytotoxicity toward HEK-293 (IC50 = 54.66 μM), RAW264.7 (IC50 = 47.88 μM), and MRC-5 (IC50 = 29.56 μM) mammalian cell lines[1].
Antifungal agent 160 (0.05-10 μg/mL; 12 h) inhibits cytochrome bc1 complex activity in Alternaria solani mycelia in a concentration-dependent manner, reducing activity by 77.4% at 10 μg/mL after 12 hours of treatment[1].
Antifungal agent 160 (0.05-10 μg/mL; 12 h) reduces ATP content and inhibits Na+-K+-ATPase activity in Alternaria solani mycelia in a concentration-dependent manner[1].
Antifungal agent 160 (0.05-10 μg/mL; 24 h) induces concentration-dependent intracellular ROS accumulation in Alternaria solani mycelia[1].
Antifungal agent 160 (5-50 μg/mL; 24 h) disrupts plasma membrane integrity of Alternaria solani mycelia in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3103869-13-9
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Molecular Weight 404.84
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Formula C20H21ClN2O5
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SMILES
CC1=C(OCC2=C(/C(C(OC)=O)=N\OC)C=CC=C2)C=CC(NC(CCl)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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