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Cat. No.: HY-155279

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Antifungal agent 73

Antifungal agent 73 (compound A32) is an antifungal agent for azole-resistant candidiasis. Antifungal agent 73 disrupts the fungal cell wall and cell membrane. Antifungal agent 73 shows potent in vivo antifungal activity against pathogenic fungi and fluconazole-resistant strains.

For research use only. We do not sell to patients.

CAS No.: 2923519-78-0
Formula: C₂₁H₁₆Cl₂N₂O₃
Molecular Weight:415.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antifungal agent 73 Chemical Structure

CAS No.: 2923519-78-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	IC₅₀	24.42 μM Compound: A32	Cytotoxicity against mouse J774.A1 cells assessed as cell growth inhibition by MTT assay Cytotoxicity against mouse J774.A1 cells assessed as cell growth inhibition by MTT assay	[PMID: 37725043]
J774.A1	IC₅₀	24.42 μM Compound: A32	Cytotoxicity against mouse J774.A1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against mouse J774.A1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 39077891]
MRC5	IC₅₀	24.42 μM Compound: A32	Cytotoxicity against human MRC5 cells assessed as cell growth inhibition by MTT assay Cytotoxicity against human MRC5 cells assessed as cell growth inhibition by MTT assay	[PMID: 37725043]

Chemical Information

CAS No. 2923519-78-0
Molecular Weight 415.27
Formula C₂₁H₁₆Cl₂N₂O₃
SMILES

ClC1=CC=C(C(Cl)=C1)C(CN2C=NC=C2)OCC3=CC4=C(C=C3)C=CC(O4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhongzuo Yan, et al. Developing Novel Coumarin-Containing Azoles Antifungal Agents by the Scaffold Merging Strategy for Treating Azole-Resistant Candidiasis. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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