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Results for "

rabbit muscle

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (2) Adrenergic Receptor (4) Aldehyde Dehydrogenase (ALDH) (1) Amino Acid Derivatives (1) Arp2/3 Complex (1) Biochemical Assay Reagents (1) Calcium Channel (11) Casein Kinase (3) Cholecystokinin Receptor (1) Cyclic GMP-AMP Synthase (3) Drug Derivative (1) Endogenous Metabolite (10) Endothelin Receptor (2) ERK (4) Fructose-1,6-bisphosphate aldolase (1) Fungal (1) Glucocorticoid Receptor (1) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (2) Lactate Dehydrogenase (1) Leukotriene Receptor (1) mAChR (3) Motilin Receptor (1) Myosin (1) nAChR (2) NO Synthase (1) Opioid Receptor (1) P2X Receptor (1) PDGFR (2) PGE synthase (1) Phosphatase (1) Phosphodiesterase (PDE) (6) Phosphorylase (2) Phytohormone (1) PKA (3) PKC (1) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (1) Prostaglandin Receptor (2) Pyruvate Kinase (1) Reference Standards (1) Sodium Channel (1) TNF Receptor (1) Tyrosine Hydroxylase (1) UGT (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (20) Endocrinology (2) Infection (2) Inflammation/Immunology (5) Metabolic Disease (18) Neurological Disease (13)

By Targets:

Adenylate Cyclase (2)

Adrenergic Receptor (4)

Aldehyde Dehydrogenase (ALDH) (1)

Amino Acid Derivatives (1)

Arp2/3 Complex (1)

Biochemical Assay Reagents (1)

Calcium Channel (11)

Casein Kinase (3)

Cholecystokinin Receptor (1)

Cyclic GMP-AMP Synthase (3)

Drug Derivative (1)

Endogenous Metabolite (10)

Endothelin Receptor (2)

ERK (4)

Fructose-1,6-bisphosphate aldolase (1)

Fungal (1)

Glucocorticoid Receptor (1)

HIF/HIF Prolyl-Hydroxylase (1)

Interleukin Related (2)

Lactate Dehydrogenase (1)

Leukotriene Receptor (1)

mAChR (3)

Motilin Receptor (1)

Myosin (1)

nAChR (2)

NO Synthase (1)

Opioid Receptor (1)

P2X Receptor (1)

PDGFR (2)

PGE synthase (1)

Phosphatase (1)

Phosphodiesterase (PDE) (6)

Phosphorylase (2)

Phytohormone (1)

PKA (3)

PKC (1)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (1)

Prostaglandin Receptor (2)

Pyruvate Kinase (1)

Reference Standards (1)

Sodium Channel (1)

TNF Receptor (1)

Tyrosine Hydroxylase (1)

UGT (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (20)

Endocrinology (2)

Infection (2)

Inflammation/Immunology (5)

Metabolic Disease (18)

Neurological Disease (13)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2807I

L-Lactate Dehydrogenase, rabbit muscle	Lactate Dehydrogenase	Others
L-Lactate Dehydrogenase, rabbit muscle is a biological material or organic compound that can be used in life science research .

HY-P2804

GAPDH, rabbit muscle 1 Publications Verification GADPH; G3PDH; Glyceraldehyde phosphate dehydrogenase	Endogenous Metabolite	Others
Glyceraldehyde phosphate dehydrogenase (EC 1.2.1.12) is the target of anti-thymocyte and anti-apoptotic agents. Glyceraldehyde phosphate dehydrogenase catalyzes the chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals .

HY-P2726

Aldolase, Rabbit muscle Fructose-diphosphate aldolase	Fructose-1,6-bisphosphate aldolase Endogenous Metabolite	Metabolic Disease
Aldolase, Rabbit muscle (Fructose-diphosphate aldolase) is a glycolytic enzyme and glucose availability sensor. Aldolase, Rabbit muscle catalyzes the reversible carbon-carbon cleavage of fructose-1,6-bisphosphate to produce dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Aldolase, Rabbit muscle is an essential component for v-ATPase activity. Aldolase, Rabbit muscle participates in processes such as gluconeogenesis, the Calvin cycle and glycolysis .

HY-P2952

Recombinant myokinase, Rabbit muscle Myokinase; Adk	Endogenous Metabolite	Others
Recombinant myokinase, Rabbit muscle (Myokinase), is a phosphotransferase enzyme, is often used in biochemical studies. Recombinant myokinase, Rabbit muscle catalyzes the interconversion of adenosine phosphates. Recombinant myokinase, Rabbit muscle monitors phosphate nucleotide levels inside the cell, it plays an important role in cellular energy homeostasis .

HY-B2141

Bendazol	NO Synthase HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Others Metabolic Disease
Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats .

HY-P2799

Creatine phosphokinase, Rabbit muscle 1 Publications Verification CPK	Endogenous Metabolite	Metabolic Disease Cancer
Creatine phosphokinase, Rabbit muscle (CPK) catalyzes the reversible reaction of creatine and ATP to form phosphocreatine and ADP. Creatine phosphokinase is a key enzyme for maintaining a constant ATP/ADP ratio during rapid energy turnover .

HY-117040

nor-Binaltorphimine 5+ Cited Publications Norbinaltorphimine; NorBNI	Opioid Receptor	Neurological Disease
nor-Binaltorphimine (Norbinaltorphimine; NorBNI) is a selective, long-acting competitive antagonist of the κ-opioid receptor. nor-Binaltorphimine blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. nor-Binaltorphimine suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. nor-Binaltorphimine is applicable to research related to neurological disorders such as pain .

HY-P2806A

Pyruvate Kinase (PK),Rabbit Muscle ATP:Pyruvate 2-0-phosphotransferase,PK	Pyruvate Kinase	Metabolic Disease Cancer
Pyruvate Kinase (PK),Rabbit Muscle (ATP:Pyruvate 2-0-phosphotransferase,PK) is a biological material or organic compound that can be used in life science research .

HY-B1016

Trapidil AR-12008	PDGFR Phosphodiesterase (PDE) Prostaglandin Receptor	Cardiovascular Disease Neurological Disease
Trapidil (AR-12008) is an orally active vasodilator and antiplatelet agent. Trapidil antagonizes platelet-derived growth factor (PDGF), inhibits phosphodiesterase, thromboxane A₂ synthesis and pro-inflammatory cytokine production. Trapidil promotes prostacyclin biosynthesis, reduces lipid peroxidation, regulates nitric oxide metabolism, and inhibits cell proliferation and migration. Trapidil exerts tissue-protective effects, regulates bone turnover, and inhibits pyroptosis via the GPX3/Nrf2 pathway. Trapidil is applicable to research related to renal ischemia-reperfusion injury, chronic stable angina, restenosis, meningioma, diabetic cardiomyopathy and peripheral nerve crush injury .

HY-B1608

Chromium chloride		Cardiovascular Disease Metabolic Disease
Chromium chloride is a trivalent chromium compound and an essential trace mineral. Chromium chloride enhances insulin-stimulated GLUT4 translocation and glucose uptake in skeletal muscle. Chromium chloride regulates glucose and lipid metabolism, inhibits TNF-α secretion and oxidative stress in monocytes treated with high glucose or H₂O₂, and reverses hydrogen peroxide-induced cell growth inhibition. Chromium chloride reduces coronary and aortic lipid deposition and serum cholesterol levels in hypercholesterolemic rabbits. Chromium chloride can be used in research related to diabetes and cardiac atherosclerosis .

HY-B1035

Levobunolol hydrochloride 1 Publications Verification l-Bunolol hydrochloride	Adrenergic Receptor Calcium Channel Casein Kinase	Cardiovascular Disease
Levobunolol (l-Bunolol) hydrochloride is a non-selective β-adrenergic antagonist and vasodilator. By blocking calcium ion influx and reducing the sensitivity of vascular smooth muscle to calcium, Levobunolol hydrochloride effectively dilates the ciliary arteries and increases ocular blood flow, so it is widely used in research on glaucoma and ocular hypertension. Levobunolol hydrochloride inhibits the β-receptor signaling pathway and the expression of related proliferation markers (such as CK3, CK14, CK19, Ki67) in corneal cells. In rabbit models, Levobunolol hydrochloride not only does not inhibit corneal epithelial regeneration, but also accelerates the healing of mechanical injury without adverse effects. Levobunolol hydrochloride also inhibits histamine-induced vasoconstriction and intracellular calcium elevation, exhibiting unique vascular regulatory activity. Levobunolol hydrochloride protects ocular blood flow and promotes corneal repair .

HY-18740A

Trequinsin hydrochloride HL 725	Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease Cancer
Trequinsin hydrochloride (HL 725) is a PDE inhibitor, CatSper channel activator, and sperm potassium channel modulator. Trequinsin hydrochloride targets PDE3 with an IC₅₀ of <1 nM. Trequinsin hydrochloride enhances currents and elevates intracellular calcium and cGMP levels via direct activation of the CatSper channel, while inhibiting the outward current conductance of sperm potassium channels. Without inducing premature acrosome reaction, Trequinsin hydrochloride significantly enhances sperm hyperactivated motility, forward motility, and the ability to penetrate viscous media. Trequinsin hydrochloride exerts age-specific positive inotropic and positive lusitropic effects on rabbit ventricular papillary muscles. Trequinsin hydrochloride has been used in studies on the mechanisms underlying male infertility (e.g., asthenozoospermia) .

HY-P2820

Phosphoglucomutase, Rabbit muscle	Endogenous Metabolite	Metabolic Disease
Phosphoglucomutase, Rabbit muscle is often used in biochemical studies. Phosphoglucomutase is an enzyme that can transfer the phosphate group on the α-D-glucose monomer forward from the 1-position to the 6-position or reversely transfer from the 6-position to the 1-position, and promote the glucose-1-phosphate and glucose-6-phosphate Transform each other. Phosphoglucomutase is a key enzyme in glycolysis and gluconeogenesis, and plays an important role in the metabolism of proteins, lipids and nucleic acids .

HY-P2765

Glycerol-3-phosphate dehydrogenase, rabbit muscle GPDH; α-Glycerophosphate dehydrogenase; Glycerol phosphate dehydrogenase	Endogenous Metabolite	Metabolic Disease
Glycerol-3-phosphate dehydrogenase, rabbit muscle (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate. Glycerol-3-phosphate dehydrogenase is a glycolytic enzyme and is responsible for the re-oxidation of NADH to NAD ⁺ and energy supply .

HY-B1087

Prednisolone hemisuccinate Prednisolone 21-hemisuccinate	Glucocorticoid Receptor	Neurological Disease
Prednisolone hemisuccinate (Prednisolone 21-hemisuccinate) is a prodrug of Prednisolone (HY-17463) and a glucocorticoid. Prednisolone hemisuccinate converts to Prednisolone in vivo. Prednisolone hemisuccinate induces the inactivation of glyceraldehyde-3-phosphate dehydrogenase (GAP-DH) in vitro. Prednisolone hemisuccinate can be used in research related to cataracts .

HY-P2918

Phosphoglucose Isomerase, Rabbit muscle GPI; Phosphoglucose Isomerase	Endogenous Metabolite	Metabolic Disease Cancer
Phosphoglucose Isomerase, Rabbit muscle (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-118824A

N-Feruloylserotonin (E/Z)-Moschamine	Calcium Channel PDGFR ERK	Cardiovascular Disease Inflammation/Immunology
N-Feruloylserotonin ((E/Z)-Moschamine) is a serotonin hydroxycinnamic acid amide. It can be isolated from a variety of plants, particularly the seeds of safflower (Carthamus tinctorius L.). N-Feruloylserotonin inhibits KCl- and 5-HT-induced elevation of intracellular [Ca ²⁺]_i. It suppresses PDGF-BB-induced phosphorylation of PDGFRβ and ERK1/2. N-Feruloylserotonin exerts anti-inflammatory effects on aortic endothelial cells. It inhibits atherosclerotic plaque formation in apolipoprotein E-deficient mice .

HY-P2734

Phosphorylase a, rabbit muscle	Phosphatase	Others
Phosphorylase a, rabbit muscle is glycogen phosphorylase isolated from rabbit muscle. Phosphorylase a, rabbit muscle catalyzes glycogenolysis, converting glycogen and inorganic phosphate into glucose-1-phosphate to supply energy for muscle contraction .

HY-108960

PPADS	P2X Receptor Interleukin Related	Neurological Disease
PPADS is a P2X receptor (P2X Receptor) antagonist and a reversible competitive antagonist of NAADP receptors, with IC₅₀ values of 68 nM (P2X1) and 214 nM (P2X3), respectively. PPADS alleviates pain-related behaviors in the central and peripheral nervous systems of mice after peripheral neuropathy, inhibits the overproduction of IL-1β, IL-6, iNOS and nNOS, and suppresses the hydrolytic activity of extracellular ATPase. PPADS blocks ATP-mediated inward currents on recombinant rat P2X₁ and P2X₃ receptors, and inhibits purinergic nerve stimulation-induced contraction of rabbit bladder detrusor muscle. PPADS is applicable to research related to neuropathic pain .

HY-19261

T-0632	Cholecystokinin Receptor	Metabolic Disease
T-0632 is a CCK A receptor antagonist that exhibits significant pharmacological properties in in vitro studies. T-0632 competitively inhibits the binding of [125I]CCK-8 to rat pancreatic CCK A receptors with a K_i value of 0.24 nM, which is significantly lower than the K_i value for guinea pig CCK B receptors. T-0632 has higher selectivity in inhibiting CCK-8-stimulated pancreatic enzyme release, with an IC_50 value of 5.0 nM, which is more advantageous than L-364,718 and loxiglumide. In rabbit gallbladder smooth muscle, the antagonistic effects of T-0632 and loxiglumide are reversible, while L-364,718 shows a persistent inhibitory effect. These results indicate that T-0632 is a highly potent, reversible and more selective CCK A receptor antagonist.

HY-P0004A

Lysipressin acetate 2 Publications Verification Lysine vasopressin acetate; [Lys8]-Vasopressin acetate	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-123468

HA-1004	Cyclic GMP-AMP Synthase PKA ERK Tyrosine Hydroxylase Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HY-N4267

Yangambin	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related	Cardiovascular Disease Infection Inflammation/Immunology
Yangambin is a PAF receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺ channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-N3931

Gardneramine	Others	Cardiovascular Disease
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines .

HY-106523

Nipradolol KT 210; K 351; Hypadil	Adrenergic Receptor	Cardiovascular Disease
Nipradolol (KT-210; K-351) is a potent blocker of alpha-1-adrenergic receptors. Nipradolol inhibits the increase of intraocular pressure (IOP) in an albino rabbit model induced by Phenylephrine (HY-B0769). Nipradolo suppresses the noradrenaline (NA)-induced muscles contraction, also exhibits vasodilator activity on the dog coronary artery .

HY-106718

Barucainide	Sodium Channel	Cardiovascular Disease
Barucainide is an Ib-class anti-arrhythmic agent (moderately blocking sodium channel). Barucainide exhibits concentration-dependent inhibitory effects on the maximum upstroke velocity (V_max) of Purkinje fibers and ventricular muscle in dogs. Barucainide significantly shortens the action potential duration (APD). Barucainide significantly inhibits the pacemaker activity frequency of atrial tissue in rabbits and the enhanced automaticity of Purkinje fibers under normal resting potential in response to isoproterenol. Barucainide cannot inhibit the abnormal automaticity emission frequency of canine Purkinje fibers induced by barium. Barucainide can be used for research on arrhythmias .

HY-116161A

17-Phenyl trinor PGF2α isopropyl ester	Prostaglandin Receptor	Metabolic Disease
17-Phenyl trinor PGF₂α isopropyl ester is a FP receptor agonist and intraocular pressure-lowering agent. 17-Phenyl trinor PGF₂α isopropyl ester induces iris sphincter contraction, reduces intraocular pressure and pupil diameter, causes no ocular irritation, and only leads to mild conjunctival hyperemia. 17-Phenyl trinor PGF₂α isopropyl ester is applicable to relevant research on glaucoma .

HY-105183

PD 145065	Endothelin Receptor	Others
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC₅₀ value of 4 nM for the ET_A receptor for rabbit renal artery vascular smooth muscle cells .

HY-127127

Deamino-NAD	Endogenous Metabolite	Others
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-N8628

3,4,5-Triiodobenzoic acid 3,4,5-TIBA	Phytohormone	Others
3,4,5-Triiodobenzoic acid is an auxin transport inhibitor. 3,4,5-Triiodobenzoic acid stimulates specific [ ³H]verapamil binding to zucchini microsomes. 3,4,5-Triiodobenzoic acid also increases specific [ ³H]verapamil binding to rabbit skeletal muscle membranes. 3,4,5-Triiodobenzoic acid can be used in the research of smooth muscle contraction .

HY-N6609

Magnocurarine	nAChR	Others
Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models .

HY-112348

HA-1004 hydrochloride	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 hydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 hydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein (Cyclic GMP-AMP Synthase), and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 hydrochloride an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HY-116755

Tiropramide CR 605	Phosphodiesterase (PDE)	Neurological Disease
Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia .

HY-171451

RMGPa-IN-1	Phosphorylase	Metabolic Disease
RMGPa-IN-1 (Compound 10C) is a rabbit muscle glycogen phosphorylase a (RMGPa) inhibitor with an IC₅₀ value of 82.5 μM. RMGPa-IN-1 is promising for research of diabetes .

HY-127127A

Deamino-NAD sodium	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Metabolic Disease
Deamino-NAD sodium is a structural analog of NAD+ (HY-B0445). Deamino-NAD sodium is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-100320

AVE5688	Phosphorylase	Metabolic Disease
AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC₅₀s of 430 nM and 915 nM and K_ds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

HY-N4080

Cyclobuxine D	mAChR	Inflammation/Immunology
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba ⁺⁺−induced contraction of the longitudinal muscle isolated from the rabbit jejunum .

HY-W424017A

Lophophine hydrochloride	Endogenous Metabolite	Neurological Disease
Lophophine hydrochloride is the drug intermediate of anhalonine and Lophophorine (HY-119478), and can be found in Lophophora diffusa. Anhalonine causes slight sleepiness in frog. Lophophorine causes long-lasting convulsions, reflex excitability, muscle stiffness, and paralysis in rabbit and frog model .

HY-P0004R

Lysipressin (Standard) Lysine vasopressin (Standard); [Lys8]-Vasopressin (Standard)	Reference Standards Adenylate Cyclase	Others
Lysipressin (Standard) is the analytical standard of Lysipressin. This product is intended for research and analytical applications. Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-126206

Quazodine MJ-1988	Phosphodiesterase (PDE)	Cardiovascular Disease
Quazodine is a Phosphodiesterase (PDE) inhibitor. Quazodine can be used in vascular smooth muscle related research .

HY-121670

Ambenoxan	Others	Neurological Disease
Ambenoxan is a central nervous system-acting skeletal muscle relaxant that is effective in mice, rats, rabbits, dogs, and monkeys without loss of the righting reflex. It has no peripheral neuromuscular blocking effects and significantly reduces or eliminates decerebrate rigidity in rabbits, but does not antagonize the effects of strychnine, leptazol, or tremorine. Like other central nervous system depressants, ambenoxan prolongs sleep duration with hexobarbitone, but it has no local anesthetic effects. In anesthetized cats, the agent lowers blood pressure and reduces the pressor response to epinephrine, but has no effect on norepinephrine.

HY-121670A

Ambenoxan hydrochloride	Adrenergic Receptor	Neurological Disease
Ambenoxan hydrochloride is a central nervous system-acting skeletal muscle relaxant that is effective in mice, rats, rabbits, dogs, and monkeys without loss of the righting reflex. It has no peripheral neuromuscular blocking effects and significantly reduces or eliminates decerebrate rigidity in rabbits, but does not antagonize the effects of strychnine, leptazol, or tremorine. Like other central nervous system depressants, ambenoxan prolongs sleep duration with hexobarbitone, but it has no local anesthetic effects. In anesthetized cats, the agent lowers blood pressure and reduces the pressor response to epinephrine, but has no effect on norepinephrine.

HY-P5526

CCK1-specific peptide substrate	Casein Kinase	Others
CCK1-specific peptide substrate is a biological active peptide. (This peptide sequence is based on rabbit muscle glycogen synthase with Ser7 phosphorylated. It is a peptide substrate for Casein Kinase I (CK1). CK1 phosphorylates Ser10. Ser7 is phosphorylated by PKA in vivo.)

HY-114920

Piprofurol	Calcium Channel	Cardiovascular Disease
Piprofurol is a calcium channel inhibitor. Piprofurol inhibits the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta in a concentration-dependent manner and relaxes the K ⁺-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC₅₀ of 5 μM .

HY-121701

SR33805 analog	Calcium Channel	Cardiovascular Disease
SR 33805 (analog) is an orally active Ca ²⁺ channel blocker that selectively inhibits the proliferation of smooth muscle cells. SR 33805 (analog) reduces calcium uptake by blocking calcium channels, thereby inhibiting smooth muscle cell proliferation induced by serum, platelet-derived growth factor, and basic fibroblast growth factor. SR 33805 (analog) significantly reduces intimal thickening following endothelial injury in rabbits. SR 33805 (analog) shows promise for cardiovascular disease research, such as in early atherosclerosis .

HY-16489A

Terodiline hydrochloride	mAChR Calcium Channel	Neurological Disease
Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with K_bs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca ²⁺ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence .

HY-106323

[Leu13]-Motilin KW-5139	Motilin Receptor	Metabolic Disease
[Leu13]-Motilin (KW-5139) is a motilin analogue. [Leu13]-Motilin stimulates gastrointestinal motility in the rabbit. [Leu13]-Motilin causes concentration-dependent contractions of the gastric antrum, duodenum, jejunum, ileum and the descending colon in vitro .

HY-123468A

HA-1004 dihydrochloride	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 dihydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 dihydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 dihydrochloride is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HY-171469

SKP-451	Potassium Channel	Cardiovascular Disease
SKP-451 is an ATP-sensitive potassium (K ⁺) channel agonist. SKP-451 activates the ATP-sensitive K ⁺ channels, promotes the efflux of K ⁺, causes membrane hyperpolarization, and inhibits the influx of Ca ²⁺, thereby relaxing the vascular smooth muscle. SKP-451 relaxs the canine coronary artery, rabbit basilar artery, and vertebral artery. SKP-451 also reduces the mean arterial blood pressure of conscious spontaneously hypertensive rats (SHR). SKP-451 is promising for research of cardiovascular diseases .

HY-B1035A

Levobunolol l-Bunolol	Adrenergic Receptor Casein Kinase Calcium Channel	Others
Levobunolol (l-Bunolol) is a non-selective β-adrenergic antagonist and vasodilator. By blocking calcium ion influx and reducing the sensitivity of vascular smooth muscle to calcium, Levobunolol effectively dilates the ciliary arteries and increases ocular blood flow, so it is widely used in research on glaucoma and ocular hypertension. Levobunolol inhibits the β-receptor signaling pathway and the expression of related proliferation markers (such as CK3, CK14, CK19, Ki67) in corneal cells. In rabbit models, Levobunolol not only does not inhibit corneal epithelial regeneration, but also accelerates the healing of mechanical injury without adverse effects. Levobunolol also inhibits histamine-induced vasoconstriction and intracellular calcium elevation, exhibiting unique vascular regulatory activity. Levobunolol protects ocular blood flow and promotes corneal repair .

Cat. No.	Product Name	Target	Research Area