2. Membrane Transporter/Ion Channel Neuronal Signaling Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Stem Cell/Wnt
  3. Calcium Channel PDGFR ERK
  4. N-Feruloylserotonin

N-Feruloylserotonin  (Synonyms: (E/Z)-Moschamine)

Cat. No.: HY-118824A Purity: 99.93%
COA
SDS
Handling Instructions Technical Support

N-Feruloylserotonin ((E/Z)-Moschamine) is a serotonin hydroxycinnamic acid amide. It can be isolated from a variety of plants, particularly the seeds of safflower (Carthamus tinctorius L.). N-Feruloylserotonin inhibits KCl- and 5-HT-induced elevation of intracellular [Ca2+]i. It suppresses PDGF-BB-induced phosphorylation of PDGFRβ and ERK1/2. N-Feruloylserotonin exerts anti-inflammatory effects on aortic endothelial cells. It inhibits atherosclerotic plaque formation in apolipoprotein E-deficient mice.

For research use only. We do not sell to patients.

N-Feruloylserotonin

N-Feruloylserotonin Chemical Structure

CAS No. : 68573-23-9

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Other Forms of N-Feruloylserotonin:

N-Feruloylserotonin Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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PDGFR PDGFRβ PDGFRα

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ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N-Feruloylserotonin ((E/Z)-Moschamine) is a serotonin hydroxycinnamic acid amide. It can be isolated from a variety of plants, particularly the seeds of safflower (Carthamus tinctorius L.). N-Feruloylserotonin inhibits KCl- and 5-HT-induced elevation of intracellular [Ca2+]i. It suppresses PDGF-BB-induced phosphorylation of PDGFRβ and ERK1/2. N-Feruloylserotonin exerts anti-inflammatory effects on aortic endothelial cells. It inhibits atherosclerotic plaque formation in apolipoprotein E-deficient mice[1][2].

IC50 & Target[1]

ERK1

 

ERK2

 

PDGFRβ

 

In Vitro

N-feruloylserotonin (1-100 μM) concentration-dependently inhibits the KCl- and 5-HT-induced elevation of [Ca2+]i in A7r5 cells, exerting a significant effect at concentrations ≥66 μM, but does not affect SOC-mediated Ca2+ influx at 66 μM[1].
N-feruloylserotonin (1-100 μM) inhibits 10% FBS- and PDGF-BB-induced proliferation of A7r5 cells in a concentration-dependent manner[1].
N-feruloylserotonin (1-66 μM) significantly inhibits PDGF-BB-induced migration of A7r5 cells in a concentration-dependent manner[1].
N-feruloylserotonin (10-66 μM; 5-10 minutes) inhibits PDGF-BB-induced phosphorylation of PDGFRβ and ERK1/2 in A7r5 cells in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Feruloylserotonin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: A7r5 rat aortic vascular smooth muscle cells
Concentration: 1-100 μM
Incubation Time: 10% FBS or 10 ng/ml PDGF-BB
for 24 h.
Result: Inhibited 10% FBS-stimulated A7r5 proliferation in a concentration-dependent manner, causing 60% inhibition at 100 μM.
Inhibited PDGF-BB-stimulated proliferation in a concentration-dependent manner, with significant inhibition observed at 100 μM.

Western Blot Analysis[1]

Cell Line: A7r5 rat aortic vascular smooth muscle cells
Concentration: 10-66 μM
Incubation Time: 5 or 10 minutes (with PDGF-BB stimulation)
Result: Attenuated PDGF-BB-induced PDGFRβ tyrosine phosphorylation in a concentration-dependent manner at 5 minutes post-stimulation, but not at 10 minutes.
Significantly inhibited PDGF-BB-induced ERK1/2 phosphorylation in a concentration-dependent manner from 5 to 10 minutes post-stimulation.
In Vivo

N-feruloylserotonin inhibits atheromatous plaque formation in apolipoprotein E-deficient mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

352.38

Formula

C20H20N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(/C=C/C1=CC=C(C(OC)=C1)O)NCCC2=CNC3=C2C=C(C=C3)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (283.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8378 mL 14.1892 mL 28.3785 mL
5 mM 0.5676 mL 2.8378 mL 5.6757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.93%

SDS (394 KB)

COA (247 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8378 mL 14.1892 mL 28.3785 mL 70.9461 mL
5 mM 0.5676 mL 2.8378 mL 5.6757 mL 14.1892 mL
10 mM 0.2838 mL 1.4189 mL 2.8378 mL 7.0946 mL
15 mM 0.1892 mL 0.9459 mL 1.8919 mL 4.7297 mL
20 mM 0.1419 mL 0.7095 mL 1.4189 mL 3.5473 mL
25 mM 0.1135 mL 0.5676 mL 1.1351 mL 2.8378 mL
30 mM 0.0946 mL 0.4730 mL 0.9459 mL 2.3649 mL
40 mM 0.0709 mL 0.3547 mL 0.7095 mL 1.7737 mL
50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4189 mL
60 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1824 mL
80 mM 0.0355 mL 0.1774 mL 0.3547 mL 0.8868 mL
100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7095 mL
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N-Feruloylserotonin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Feruloylserotonin68573-23-9(E/Z)-MoschamineCalcium ChannelPDGFRERKCa2+ channelsCa channelsPlatelet-derived growth factor receptorExtracellular signal regulated kinasesvascular smooth muscle cellsLDLatherosclerosisKHC rabbitsapolipoprotein E-deficient miceA7r5 cellsendothelial functionPDGF receptor βERK1/2sarcoplasmic reticulumInhibitorinhibitorinhibit

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