Cat. No.: HY-118824A

N-Feruloylserotonin

(Synonyms: (E/Z)-Moschamine)

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N-Feruloylserotonin ((E/Z)-Moschamine) is a serotonin hydroxycinnamic acid amide. It can be isolated from a variety of plants, particularly the seeds of safflower (Carthamus tinctorius L.). N-Feruloylserotonin inhibits KCl- and 5-HT-induced elevation of intracellular [Ca²⁺]_i. It suppresses PDGF-BB-induced phosphorylation of PDGFRβ and ERK1/2. N-Feruloylserotonin exerts anti-inflammatory effects on aortic endothelial cells. It inhibits atherosclerotic plaque formation in apolipoprotein E-deficient mice.

For research use only. We do not sell to patients.

Purity: 99.93%
CAS No.: 68573-23-9
Formula: C₂₀H₂₀N₂O₄
Molecular Weight:352.38

Storage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

N-Feruloylserotonin Chemical Structure

CAS No.: 68573-23-9

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Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

ERK1

ERK2

PDGFRβ

All Calcium Channel Isoforms :

All PDGFR Isoforms :

All ERK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	216 μM Compound: 6	Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation	[PMID: 19524439]
B16	IC₅₀	23 μM Compound: 6	Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days	[PMID: 19524439]
Caco-2	IC₅₀	81 μM Compound: moschamine	Anticancer activity against human Caco2 cells Anticancer activity against human Caco2 cells	[PMID: 25456382]
RAW264.7	IC₅₀	123.14 μM Compound: 2; MC	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess assay	[PMID: 29102229]
RAW264.7	IC₅₀	14.74 μM Compound: 2; MC	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production pretreated for 1 hr followed by LPS addition measured after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production pretreated for 1 hr followed by LPS addition measured after 24 hrs	[PMID: 29102229]

In Vitro

N-feruloylserotonin (1-100 μM) concentration-dependently inhibits the KCl- and 5-HT-induced elevation of [Ca²⁺]_i in A7r5 cells, exerting a significant effect at concentrations ≥66 μM, but does not affect SOC-mediated Ca²⁺ influx at 66 μM^[1].
N-feruloylserotonin (1-100 μM) inhibits 10% FBS- and PDGF-BB-induced proliferation of A7r5 cells in a concentration-dependent manner^[1].
N-feruloylserotonin (1-66 μM) significantly inhibits PDGF-BB-induced migration of A7r5 cells in a concentration-dependent manner^[1].
N-feruloylserotonin (10-66 μM; 5-10 minutes) inhibits PDGF-BB-induced phosphorylation of PDGFRβ and ERK1/2 in A7r5 cells in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A7r5 rat aortic vascular smooth muscle cells
Concentration:

1-100 μM
Incubation Time:

10% FBS or 10 ng/ml PDGF-BB
for 24 h.
Result:

Inhibited 10% FBS-stimulated A7r5 proliferation in a concentration-dependent manner, causing 60% inhibition at 100 μM.
Inhibited PDGF-BB-stimulated proliferation in a concentration-dependent manner, with significant inhibition observed at 100 μM.

Western Blot Analysis^[1]

Cell Line:

A7r5 rat aortic vascular smooth muscle cells
Concentration:

10-66 μM
Incubation Time:

5 or 10 minutes (with PDGF-BB stimulation)
Result:

Attenuated PDGF-BB-induced PDGFRβ tyrosine phosphorylation in a concentration-dependent manner at 5 minutes post-stimulation, but not at 10 minutes.
Significantly inhibited PDGF-BB-induced ERK1/2 phosphorylation in a concentration-dependent manner from 5 to 10 minutes post-stimulation.

In Vivo

N-feruloylserotonin inhibits atheromatous plaque formation in apolipoprotein E-deficient mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 68573-23-9
Appearance Solid
Molecular Weight 352.38
Formula C₂₀H₂₀N₂O₄
Color White to off-white
SMILES

O=C(/C=C/C1=CC=C(C(OC)=C1)O)NCCC2=CNC3=C2C=C(C=C3)O
Synonyms

(E/Z)-Moschamine
Structure Classification
- Alkaloids
- Indole Alkaloids
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (283.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8378 mL

14.1892 mL

28.3785 mL

5 mM

0.5676 mL

2.8378 mL

5.6757 mL

10 mM

0.2838 mL

1.4189 mL

2.8378 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takimoto T, et al. Effect of N-(p-coumaroyl)serotonin and N-feruloylserotonin, major anti-atherogenic polyphenols in safflower seed, on vasodilation, proliferation and migration of vascular smooth muscle cells. Mol Nutr Food Res. 2011;55(10):1561-1571. [Content Brief]

[2]. Katsuda S, et al. Safflower seed polyphenols (N-(p-coumaroyl)serotonin and N-feruloylserotonin) ameliorate atherosclerosis and distensibility of the aortic wall in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Hypertens Res. 2009;32(11):944-949. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8378 mL	14.1892 mL	28.3785 mL	70.9461 mL
	5 mM	0.5676 mL	2.8378 mL	5.6757 mL	14.1892 mL
	10 mM	0.2838 mL	1.4189 mL	2.8378 mL	7.0946 mL
	15 mM	0.1892 mL	0.9459 mL	1.8919 mL	4.7297 mL
	20 mM	0.1419 mL	0.7095 mL	1.4189 mL	3.5473 mL
	25 mM	0.1135 mL	0.5676 mL	1.1351 mL	2.8378 mL
	30 mM	0.0946 mL	0.4730 mL	0.9459 mL	2.3649 mL
	40 mM	0.0709 mL	0.3547 mL	0.7095 mL	1.7737 mL
	50 mM	0.0568 mL	0.2838 mL	0.5676 mL	1.4189 mL
	60 mM	0.0473 mL	0.2365 mL	0.4730 mL	1.1824 mL
	80 mM	0.0355 mL	0.1774 mL	0.3547 mL	0.8868 mL
	100 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.7095 mL

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N-Feruloylserotonin

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All Calcium Channel Isoforms

All PDGFR Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

N-Feruloylserotonin Related Classifications

Cat. No.: HY-118824A