Deoxaphomin
Deoxaphomin is a cytochalasin. Deoxaphomin inhibits Actin filament elongation and reduces the viscosity of polymerized actin filaments. Deoxaphomin induces rounding of fibroblasts, contraction of actin cables, formation of actin-containing hairy structures, and formation of actin-containing cytoplasmic rodlets in fibroblasts. Deoxaphomin inhibits membrane ruffling in fibroblasts and capping in lymphocytes.
For research use only. We do not sell to patients.
- CAS No.: 51053-39-5
- Formula: C29H37NO4
- Molecular Weight:463.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
7.6 μM
Compound: 9
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 34846891] |
Deoxaphomin (2-20 μM; 1 h) induces cell rounding in mouse fibroblast-like C3H cells within 1 hour at the concentration of 20 μM, while no such effect is observed at 2 μM[1].
Deoxaphomin (0.2-2 μM; 10 min) inhibits membrane ruffling in mouse fibroblast C3H cells at a concentration of 2 μM after 10 min of incubation, while no such effect is observed at 0.2 μM[1].
Deoxaphomin induces actin filament contraction and the formation of actin-containing hair-like structures in mouse fibroblast C3H cells[1].
Pretreatment with Deoxaphomin (20 μM) for 10 min inhibits the capping response of mouse splenic lymphocytes by 70%[1].
Deoxaphomin (20 μM) reduces the specific viscosity of purified polymerized rabbit skeletal muscle actin filaments by 12%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 51053-39-5
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Molecular Weight 463.61
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Formula C29H37NO4
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SMILES
O=C1[C@]23[C@]([C@@H](C([C@H]([C@]2([H])/C=C/C[C@@H](CCC[C@H](/C=C/C3=O)O)C)O)=C)C)([H])[C@@H](N1)CC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Deoxaphomin Related Classifications
Cat. No.: HY-182487
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- Deoxaphomin
- 51053-39-5
- Arp2/3 Complex
- mouse fibroblastic C3H cells
- rabbit skeletal muscle actin filaments
- actin cable contraction
- actin filament elongation
- actin
- polymerized actin filament viscosity
- actin-containing hairy structures
- fibroblastic cells
- cytoplasmic actin-containing rodlets
- mouse splenic lymphocytes
- Inhibitor
- inhibitor
- inhibit