Deoxaphomin 

Deoxaphomin is a cytochalasin. Deoxaphomin inhibits Actin filament elongation and reduces the viscosity of polymerized actin filaments. Deoxaphomin induces rounding of fibroblasts, contraction of actin cables, formation of actin-containing hairy structures, and formation of actin-containing cytoplasmic rodlets in fibroblasts. Deoxaphomin inhibits membrane ruffling in fibroblasts and capping in lymphocytes^[1].

Deoxaphomin (2-20 μM; 1 h) induces cell rounding in mouse fibroblast-like C3H cells within 1 hour at the concentration of 20 μM, while no such effect is observed at 2 μM^[1].
Deoxaphomin (0.2-2 μM; 10 min) inhibits membrane ruffling in mouse fibroblast C3H cells at a concentration of 2 μM after 10 min of incubation, while no such effect is observed at 0.2 μM^[1].
Deoxaphomin induces actin filament contraction and the formation of actin-containing hair-like structures in mouse fibroblast C3H cells^[1].
Pretreatment with Deoxaphomin (20 μM) for 10 min inhibits the capping response of mouse splenic lymphocytes by 70%^[1].
Deoxaphomin (20 μM) reduces the specific viscosity of purified polymerized rabbit skeletal muscle actin filaments by 12%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

463.61

C₂₉H₃₇NO₄

51053-39-5

O=C1[C@]23[C@]([C@@H](C([C@H]([C@]2([H])/C=C/C[C@@H](CCC[C@H](/C=C/C3=O)O)C)O)=C)C)([H])[C@@H](N1)CC4=CC=CC=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yahara I, et al. Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro. J Cell Biol. 1982;92(1):69-78.  [Content Brief]