Pyruvate Kinase (PK),Rabbit Muscle
Based on 1 Customer Validation
Pyruvate Kinase (PK),Rabbit Muscle (ATP:Pyruvate 2-0-phosphotransferase,PK) is a biological material or organic compound that can be used in life science research.
For research use only. We do not sell to patients.
- CAS No.: 9001-59-6
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Four Pyruvate Kinase isoforms are found in mammals: PKM1 that is mainly expressed in tissues with high catabolic demand, such as muscle, heart and brain; PKM2 that is mainly expressed in embryonic tissues, many adult tissues (such as lymphocytes and intestinal epithelial cells), and cancer cells; PKR that is only expressed in erythrocytes; and PKL that is expressed in the liver, with a small amount of expression in the kidney[3].
PKM1 affects cell proliferation and tumor suppression by regulating glucose oxidation and nucleotide synthesis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
2.7.1.40
350 - 600 U/mg protein
One unit is defined as the amount of enzyme that convert 1 μmol of Phospho(enol)pyruvate to Pyruvate per min at pH 7.6 at 37°C.
Chemical Information
-
CAS No. 9001-59-6
-
Appearance Solid
-
Color White to off-white
-
SMILES
[Pyruvate Kinase (PK),Rabbit Muscle]
-
Synonyms
ATP:Pyruvate 2-0-phosphotransferase,PK
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (265 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
[1]. Pyruvate Kinase (PK),Rabbit Muscle [Content Brief]
[2]. Nicolson GL, Singer SJ. Ferritin-conjugated plant agglutinins as specific saccharide stains for electron microscopy: application to saccharides bound to cell membranes. Proc Natl Acad Sci U S A. 1971 May;68(5):942-5. [Content Brief]
[3]. Israelsen WJ, et al., Pyruvate kinase: Function, regulation and role in cancer. Semin Cell Dev Biol. 2015 Jul;43:43-51. [Content Brief]
[4]. Davidson SM, et al., Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma. Cancer Res. 2022 Jul 5;82(13):2403-2416. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pyruvate Kinase (PK),Rabbit Muscle Related Classifications
HY-P2806A Related Classifications
Powered by Bioz