Pyruvate Kinase (PK),Rabbit Muscle  (Synonyms: ATP:Pyruvate 2-0-phosphotransferase,PK)

Pyruvate Kinase (PK),Rabbit Muscle (ATP:Pyruvate 2-0-phosphotransferase,PK) is a biological material or organic compound that can be used in life science research^[1][2].

Four Pyruvate Kinase isoforms are found in mammals: PKM1 that is mainly expressed in tissues with high catabolic demand, such as muscle, heart and brain; PKM2 that is mainly expressed in embryonic tissues, many adult tissues (such as lymphocytes and intestinal epithelial cells), and cancer cells; PKR that is only expressed in erythrocytes; and PKL that is expressed in the liver, with a small amount of expression in the kidney^[3].
PKM1 affects cell proliferation and tumor suppression by regulating glucose oxidation and nucleotide synthesis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9001-59-6

Solid

White to off-white

[Pyruvate Kinase (PK),Rabbit Muscle]

2.7.1.40

350 - 600 U/mg protein

One unit is defined as the amount of enzyme that convert 1 μmol of Phospho(enol)pyruvate to Pyruvate per min at pH 7.6 at 37°C.

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pyruvate Kinase (PK),Rabbit Muscle  [Content Brief]

  [2]. Nicolson GL, Singer SJ. Ferritin-conjugated plant agglutinins as specific saccharide stains for electron microscopy: application to saccharides bound to cell membranes. Proc Natl Acad Sci U S A. 1971 May;68(5):942-5.  [Content Brief]

  [3]. Israelsen WJ, et al., Pyruvate kinase: Function, regulation and role in cancer. Semin Cell Dev Biol. 2015 Jul;43:43-51.  [Content Brief]

  [4]. Davidson SM, et al., Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma. Cancer Res. 2022 Jul 5;82(13):2403-2416.  [Content Brief]