1. PI3K/Akt/mTOR
    Cell Cycle/DNA Damage
  2. mTOR
    PI3K
    CDK
  3. hSMG-1 inhibitor 11e

hSMG-1 inhibitor 11e 

Cat. No.: HY-124760
Handling Instructions

hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of <0.05 nM. hSMG-1 inhibitor 11e shows >900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM).

For research use only. We do not sell to patients.

hSMG-1 inhibitor 11e Chemical Structure

hSMG-1 inhibitor 11e Chemical Structure

CAS No. : 1402452-10-1

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Description

hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of <0.05 nM. hSMG-1 inhibitor 11e shows >900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM)[1].

IC50 & Target[1]

hSMG-1

<0.05 nM (IC50)

mTOR

45 nM (IC50)

PI3Kα

61 nM (IC50)

PI3Kγ

92 nM (IC50)

CDK1

32 μM (IC50)

CDK2

7.1 μM (IC50)

In Vitro

hSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

517.60

Formula

C₂₆H₂₇N₇O₃S

CAS No.

1402452-10-1

SMILES

O=S(C1=CC(NC2=NC=CC(C3=CC(C4=CC=C(NC(NC)=O)C=C4)=NC=C3)=N2)=CC=C1C)(N(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

hSMG-1 inhibitor 11emTORPI3KCDKMammalian target of RapamycinPhosphoinositide 3-kinaseCyclin dependent kinasehSMG-1PI3KαPI3KγanticancerInhibitorinhibitorinhibit

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hSMG-1 inhibitor 11e
Cat. No.:
HY-124760
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