78 Results for "

Hepatoprotective effects

" in MedChemExpress (MCE) Product Catalog:
Products (78)

78 Results for "Hepatoprotective effects" in MCE Product Catalog:

15
Thymoquinone
Thymoquinone
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15 Publications Verification
Cat. No.: HY-D0803
CAS No.: 490-91-5
Category:  

Quinones Nigella sativa L. Ranunculaceae Benzene Quinones Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis VEGFR PI3K Akt

Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .
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14
Pitavastatin
Pitavastatin
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14 Cited Publications
Cat. No.: HY-B0144A
CAS No.: 147511-69-1
Synonyms: NK-104
Target:  

HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .
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14
Pitavastatin Calcium
Pitavastatin Calcium
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14 Cited Publications
Cat. No.: HY-B0144
CAS No.: 147526-32-7
Synonyms: NK-104 hemicalcium; Pitavastatin hemicalcium
Target:  

HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .
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11
Aucubin
Aucubin
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11 Cited Publications
Cat. No.: HY-N0664
CAS No.: 479-98-1
Category:  

Infection Eucommia ulmoides Oliver Neurological Disease Iridoids Terpenoids Eucommiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Bacterial

Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .
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10
3,4-Dicaffeoylquinic acid
3,4-Dicaffeoylquinic acid
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10 Cited Publications
Cat. No.: HY-N0057
CAS No.: 14534-61-3
Synonyms: 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B
Category:  

Infection Caprifoliaceae Ketones, Aldehydes, Acids Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields

Target:  

Free Radical Scavengers Glycosidase Influenza Virus Apoptosis Endogenous Metabolite

3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL .
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9
Echinatin
Echinatin
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9 Cited Publications
Cat. No.: HY-N0269
CAS No.: 34221-41-5
Category:  

Flavonoids Chalcones Leguminosae Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:  

Apoptosis Autophagy NOD-like Receptor (NLR)

Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects . Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat .
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7
Farrerol
Farrerol
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7 Cited Publications
Cat. No.: HY-N0344
CAS No.: 24211-30-1
Synonyms: (-)-Farrerol
Category:  

Neurological Disease  Rhododendron dauricum Linn. Plants Flavonoids Flavonones Phenols Polyphenols Ericaceae Disease Research Fields Inflammation/Immunology

Target:  

Others

Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects .
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4
Typhaneoside
Typhaneoside
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4 Cited Publications
Cat. No.: HY-N0712
CAS No.: 104472-68-6
Category:  

Cardiovascular Disease Flavonols Flavonoids Typhaceae Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields

Target:  

mTOR Akt FXR PI3K Autophagy Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Calcium Channel

Typhaneoside is an orally active activator of PI3K/Akt/mTOR and farnesoid X receptor. Typhaneoside promotes the activation of AMPK and Caspase-3, induces apoptosis, ferroptosis, autophagy, ROS accumulation, cell cycle arrest at the G2/M phase, and reduces cancer cell viability. Typhaneoside improves glucose and lipid metabolism, alleviates inflammatory responses, oxidative stress and hepatic lipid accumulation, and exerts hepatoprotective effects. Typhaneoside can be used in research related to heart failure after myocardial infarction, acute myeloid leukemia, non-alcoholic fatty liver disease and neurological disorders .
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3
Saponarin
Saponarin
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3 Cited Publications
Cat. No.: HY-N5083
CAS No.: 20310-89-8
Category:  

Flavonoids Flavones Dipsacaceae  Dipsacus sativus (Linn.) Honck. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

PERK NF-κB p38 MAPK AMPK Interleukin Related COX

Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1β and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders .
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2
Schisandrol B
Schisandrol B
0 Images
2 Cited Publications
Cat. No.: HY-N0692
CAS No.: 58546-54-6
Synonyms: Gomisin-A; TJN-101; Wuweizi alcohol-B
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy

Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
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2
Chikusetsusaponin Iva
Chikusetsusaponin Iva
0 Images
2 Cited Publications
Cat. No.: HY-N0818
CAS No.: 51415-02-2
Synonyms: Calenduloside F
Category:  

Triterpenes Terpenoids Other Diseases Amaranthaceae Plants Alternanthera philoxeroides (Mart.) Griseb. Disease Research Fields

Target:  

Keap1-Nrf2

Chikusetsusaponin IVa is an orally active protein kinase activator. Chikusetsusaponin IVa binds to YAP with a KD value of 0.388 mM. Chikusetsusaponin IVa reduces inflammatory mediators (IL-6, IL-10, COX-2) expression, NO production, promotes ROS generation, induces Apoptosis, inhibits MAPK, TAZ, and regulates Nrf2, JAK/STAT. Chikusetsusaponin Iva has anti-H9N2 AIV and anti-endometrial cancer activities. Chikusetsusaponin Iva shows anti-inflammatory, hepatoprotective and osteoprotective effects .
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2
Amarogentin
Amarogentin
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2 Cited Publications
Cat. No.: HY-N2447
CAS No.: 21018-84-8
Category:  

Gentiana scabra Bunge Iridoids Terpenoids Gentianaceae Metabolic Disease Phenols Polyphenols Plants Disease Research Fields

Target:  

AMPK Apoptosis

Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .
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1
β-Glucogallin
β-Glucogallin
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1 Cited Publications
Cat. No.: HY-133708
CAS No.: 13405-60-2
Purity:  99.82%
Synonyms: Glucogallin; 1-O-Galloyl-β-D-glucose
Category:  

Phyllanthaceae Phenols Polyphenols Phyllanthus emblica L. Plants

Target:  

Aldose Reductase Reactive Oxygen Species (ROS) NF-κB PDGFR SOD

β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC50 value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research .
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1
4-Hydroxyacetophenone
4-Hydroxyacetophenone
0 Images
1 Cited Publications
Cat. No.: HY-Y0073
CAS No.: 99-93-4
Synonyms: P-hydroxyacetophenone
Category:  

Monophenols Ketones, Aldehydes, Acids Phenols Plants Compositae Disease Research Fields Inflammation/Immunology Artemisia capillaris Thunb.

Target:  

HBV Myosin

4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .
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1
Bovinic acid
Bovinic acid
0 Images
1 Cited Publications
Cat. No.: HY-113162
CAS No.: 2540-56-9
Purity:  96.21%
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Keap1-Nrf2 Ferroptosis Reactive Oxygen Species (ROS) SOD

Bovinic acid is an orally active anti-inflammatory agent. Bovinic acid inhibits oxidative stress and ferroptosis by regulating the Keap1-Nrf2 signaling pathway. Bovinic acid exerts hepatoprotective effects against alcohol-associated liver disease. Bovinic acid can be used for the research of alcohol-associated liver disease .
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1
(±)-Catechin
(±)-Catechin
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1 Cited Publications
Cat. No.: HY-B1890
CAS No.: 7295-85-4
Synonyms: rel-Cianidanol; rel-Catechuic acid
Category:  

Cardiovascular Disease Neurological Disease Plants Camellia sinensis (L.) O. Ktze. Infection Phenols Polyphenols Disease Research Fields Inflammation/Immunology Theaceae

Target:  

COX

(±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects .
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1
Swertiamarin
Swertiamarin
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1 Cited Publications
Cat. No.: HY-N0807
CAS No.: 17388-39-5
Category:  

other families Monophenols Metabolic Disease Phenols Zanthoxylum chiloperone var. angustifolium Plants Disease Research Fields Cancer

Target:  

MMP NF-κB JAK Keap1-Nrf2

Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .
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1
Pinoresinol 4-O-β-D-glucopyranoside
Pinoresinol 4-O-β-D-glucopyranoside
0 Images
1 Cited Publications
Cat. No.: HY-N2168
CAS No.: 69251-96-3
Synonyms: (+)-Pinoresinol 4-O-β-D-glucopyranoside
Category:  

Cardiovascular Disease other families Monophenols Lignans Phenols Phenylpropanoids Plants Disease Research Fields

Target:  

Glycosidase Free Radical Scavengers Estrogen Receptor/ERR Phosphodiesterase (PDE)

Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC50 of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .
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1
Agrimonolide
Agrimonolide
0 Images
1 Cited Publications
Cat. No.: HY-N2830
CAS No.: 21499-24-1
Category:  

Other Diseases Rosaceae Phenols Polyphenols Pteris wallichiana Agardh Plants Disease Research Fields

Target:  

NF-κB Ferroptosis MAPKAPK2 (MK2) Toll-like Receptor (TLR) Notch JAK STAT HIF/HIF Prolyl-Hydroxylase

Agrimonolide is a phenethyl isocoumarin compound discovered from Agrimonia pilosa, exhibiting anti-inflammatory, antioxidant, and anticancer activities. Agrimonolide inhibits NF-κB, MAPK, and TLR4-mediated neuroinflammatory signaling, suppresses Notch and JAK2/STAT3 signaling to modulate Th17/Treg balance and maintain the intestinal barrier. Agrimonolide decreases HIF1A expression, inhibits glycolysis, and induces ferroptosis and cell cycle arrest via the mTOR pathway in tumor models, thereby suppressing cancer cell viability, proliferation, and metastasis. Agrimonolide exerts hepatoprotective and anti-fibrotic effects by regulating bile acid transporter expression and reducing hepatic bile acid accumulation. Agrimonolide is used for research on ulcerative colitis, ovarian cancer, non-small cell lung cancer, cholestatic liver injury, and neuroinflammation .
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1
Hederasaponin B
Hederasaponin B
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1 Cited Publications
Cat. No.: HY-N0306
CAS No.: 36284-77-2
Category:  

Infection Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Terpenoids Plants Disease Research Fields Araliaceae

Target:  

Enterovirus

Hederasaponin B is an orally active oleanane-type triterpenoid saponin and antiviral agent. Hederasaponin B is isolated from the leaves of Acanthopanax senticosus, Hedera nepalensis var. sinensis, and the rhizomes of Souliea vaginata. Hederasaponin B inhibits the expression of the viral capsid protein VP2 and attenuates virus-induced cytopathic effects. Hederasaponin B exhibits activity against Enterovirus 71 subtypes C3 and C4a. Hederasaponin B shows no hepatoprotective effect against CCl4-induced hepatocyte injury. Hederasaponin B is used in research on hand, foot, and mouth disease .
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