8-Deoxylactucin
Based on 1 Customer Validation
8-Deoxylactucin is an orally active sesquiterpene lactone. 8-Deoxylactucin inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages with an IC50 value of 4.35 μM. 8-Deoxylactucin exerts anti-inflammatory effects by blocking the NF-κB pathway. 8-Deoxylactucin demonstrates hepatoprotective efficacy in LPS/D-galactosamine-induced acute hepatitis model of mice. 8-Deoxylactucin can be used for the study of inflammatory diseases and inflammatory liver injuries.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 65725-10-2
- Formula: C15H16O4
- Molecular Weight:260.29
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | ED50 |
3.1 μM
Compound: deoxyLactucin
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 18329753] |
8-Deoxylactucin (1 h pretreatment) significantly inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages, with an IC50 of 4.35 μM[1].
8-Deoxylactucin (1-10 μM, 1 h pretreatment) significantly reduces LPS-induced mRNA and protein expression of iNOS, as well as mRNA expression of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α in RAW264.7 cells[1].
8-Deoxylactucin (1-10 μM, 2 h pretreatment) significantly blocks LPS-induced phosphorylation of IKKα/β and IκBα, inhibits IκBα degradation, and reduces nuclear accumulation of NF-κB p65 in RAW264.7 macrophages[1].
8-Deoxylactucin (1-10 μM, 1 h pretreatment) significantly enhances protein expression and nuclear translocation of NRF2, up-regulates protein expression of NRF2-targeted antioxidant genes (HO, NQO1), and reduces ROS production in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 macrophages
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Concentration:1, 5, 10 μM
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Incubation Time:1, 2 h pretreatment
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Result:Reduced the mRNA expression of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α in RAW264.7 cells.
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Cell Line:RAW264.7 macrophages
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Concentration:1, 5, 10 μM
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Incubation Time:1, 2 h pretreatment
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Result:Reduced LPS-induced expression of iNOS.
Blocked LPS-induced phosphorylation of IKKα/β and IκBα.
Inhibited IκBα degradation.
Reduced nuclear accumulation of NF-κB p65.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS/D-galactosamine (D-GalN) (LPS: 50 μg/kg, D-GalN: 700 mg/kg, i.p. injection) was administered to 6-week-old male ICR mice (22-24 g) to induce acute hepatitis model[1]
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Dosage:2, 5, 10 mg/kg
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Administration:i.g., once daily, 5 days
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Result:Achieved significant reduction in liver index.
Showed significant alleviation of liver tissue damage and decreased pathological scores.
Reduced serum ALT and AST levels.
Decreased protein expression of IL-1β, IL-6, TNF-α, and 4-HNE in liver tissues.
Chemical Information
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CAS No. 65725-10-2
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Appearance Oil
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Molecular Weight 260.29
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Formula C15H16O4
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Color Off-white to light brown
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SMILES
OCC([C@]1([H])[C@]2([H])[C@](CCC(C)=C13)([H])C(C(O2)=O)=C)=CC3=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
8-Deoxylactucin Related Classifications
HY-N12087 Related Classifications
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