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FH1 (Synonyms: NSC 12407; BRD-K4477)

Cat. No.: HY-12346 Purity: 99.42%
Handling Instructions

FH1 (NSC 12407) enhances hepatocyte functions, and promotes the differentiation of induced pluripotent stem (iPS)-derived hepatocytes toward a phenotype more mature and the maturation of well-differentiated cultures of hepatocyte-like cells (iHeps).

For research use only. We do not sell to patients.

FH1 Chemical Structure

FH1 Chemical Structure

CAS No. : 2719-05-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 320 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

FH1 (NSC 12407) enhances hepatocyte functions, and promotes the differentiation of induced pluripotent stem (iPS)-derived hepatocytes toward a phenotype more mature and the maturation of well-differentiated cultures of hepatocyte-like cells (iHeps)[1].

In Vitro

FH1 (NSC 12407, 5 µg/mL, 0-40 days) enhances hepatic maturation and maintain the hepatic differentiation state of hiPSC-HLCs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: hiPSC-HLCs in the differentiated hepatic state.
Concentration: 5 µg/mL.
Incubation Time: 0-40 days.
Result: Kept more than 50% hiPSC-HLCs to produce the four factors till day 40.
Can help hiPSC-HLCs to maintain a relatively mature hepatic differentiation state for about 40 days.
Maintained a higher level of hALB in the supernatant than that in controls.
Maintained relatively high mRNA levels of hNTCP, hRXR, hHNF4α, and hALB for over functional small molecule FH1 can help hiPSC-HLCs to maintain a relatively mature hepatic differentiation state for about 40 days.
Molecular Weight

282.34

Formula

C17H18N2O2

CAS No.
SMILES

CC(NC1=CC=C(CC2=CC=C(NC(C)=O)C=C2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 13 mg/mL (46.04 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5418 mL 17.7091 mL 35.4183 mL
5 mM 0.7084 mL 3.5418 mL 7.0837 mL
10 mM 0.3542 mL 1.7709 mL 3.5418 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
FH1
Cat. No.:
HY-12346
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