2. Protein Tyrosine Kinase/RTK Anti-infection
  3. FGFR HSV VEGFR
  4. Surfen dihydrochloride

Surfen dihydrochloride  (Synonyms: Aminoquincarbamide dihydrochloride)

Cat. No.: HY-122704A Purity: ≥99.0%
COA Handling Instructions

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Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection.

For research use only. We do not sell to patients.

Surfen dihydrochloride Chemical Structure

Surfen dihydrochloride Chemical Structure

CAS No. : 5424-37-3

Size Price Stock Quantity
5 mg USD 105 In-stock
10 mg USD 165 In-stock
25 mg USD 350 In-stock
50 mg USD 580 In-stock
100 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

Surfen dihydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Surfen dihydrochloride

View All FGFR Isoform Specific Products:

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].

IC50 & Target

FGFR2

5 μM (IC50)

HSV-1

 

Molecular Weight

445.34

Formula

C21H22Cl2N6O
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C(NC1=CC=C2N=C(C)C=C(N)C2=C1)NC3=CC=C4N=C(C)C=C(N)C4=C3.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 8 mg/mL (17.96 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2455 mL 11.2274 mL 22.4548 mL
5 mM 0.4491 mL 2.2455 mL 4.4910 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (248 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.2455 mL 11.2274 mL 22.4548 mL 56.1369 mL
5 mM 0.4491 mL 2.2455 mL 4.4910 mL 11.2274 mL
10 mM 0.2245 mL 1.1227 mL 2.2455 mL 5.6137 mL
15 mM 0.1497 mL 0.7485 mL 1.4970 mL 3.7425 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Surfen dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Surfen5424-37-3AminoquincarbamideFGFRHSVVEGFRFibroblast growth factor receptorHerpes simplex virusVascular endothelial growth factor receptorantithrombinglycosaminoglycansgrowth factorsviral infectionangiogenesisInhibitorinhibitorinhibit

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