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Results for "

PAH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (7) Apelin Receptor (APJ) (1) Apoptosis (13) Aryl Hydrocarbon Receptor (5) Autophagy (3) Bacterial (6) Biochemical Assay Reagents (4) c-Fms (1) c-Kit (1) c-Myc (2) Caspase (2) Collagen (3) Cytochrome P450 (3) DNA/RNA Synthesis (1) Dopamine Receptor (2) Drug Intermediate (4) Drug Metabolite (3) Dynamin (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (8) Endothelin Receptor (4) Environmental Pollutants (8) Estrogen Receptor/ERR (3) FGFR (2) Fluorescent Dye (7) Fungal (1) G Protein-coupled Receptor Kinase (GRK) (1) HDAC (2) HSP (2) Interleukin Related (3) Isotope-Labeled Compounds (12) LPL Receptor (3) mAChR (4) MDM-2/p53 (1) p38 MAPK (3) PDGFR (1) Phosphatase (1) Phosphodiesterase (PDE) (5) Phosphoramidites (1) Prostaglandin Receptor (2) Reactive Oxygen Species (ROS) (4) Reference Standards (15) SARS-CoV (2) Small Interfering RNA (siRNA) (3) SOD (2) Sodium Channel (1) SphK (4) STAT (2) TGF-beta/Smad (1) TGF-β Receptor (4) TNF Receptor (3) TRP Channel (1) Tryptophan Hydroxylase (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (32) Endocrinology (3) Infection (10) Inflammation/Immunology (22) Metabolic Disease (8) Neurological Disease (10)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Uracil (1) Phosphoramidites (1) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Inhibitory Antibodies

Natural
Products

Protéines recombinantes

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

DMBA 3 Publications Verification 7,12-DMBA; 7,12-Dimethylbenzanthracene	Environmental Pollutants c-Myc	Cancer
DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .

Sapropterin dihydrochloride 2 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

Macitentan 10+ Cited Publications ACT-064992	Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

PF-543 Maximum Cited Publications 22 Publications Verification Sphingosine Kinase 1 Inhibitor II	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy .

Epoprostenol sodium 1 Publications Verification Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan	Endogenous Metabolite Apoptosis	Cardiovascular Disease
Epoprostenol sodium (Prostaglandin I2) sodium salt, the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation .

Aviptadil 2 Publications Verification Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

Phenanthrene 1 Publications Verification	Environmental Pollutants Apoptosis	Inflammation/Immunology Cancer
Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .

PF-543 Citrate Maximum Cited Publications 22 Publications Verification Sphingosine Kinase 1 Inhibitor II Citrate	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy .

Seralutinib 2 Publications Verification GB002; PK10571	PDGFR c-Fms c-Kit	Cardiovascular Disease
Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC₅₀s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .

Pyrene 1 Publications Verification Benzo[def]phenanthrene	Environmental Pollutants Biochemical Assay Reagents	Others
Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

Brilaroxazine RP5063	Dopamine Receptor 5-HT Receptor	Neurological Disease Inflammation/Immunology
Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (K_i=1.5 nM) and 5-HT2A (K_i=2.5 nM), and has antagonist activity at 5-HT2B (K_i=0.19 nM), and 5-HT7 (K_i=2.7 nM) receptors . Brilaroxazine is an atypical antipsychotic agent, and has the potential to improve cognitive impairments in neuropsychiatric and neurological diseases in vivo .

1-Hydroxypyrene	Aryl Hydrocarbon Receptor Cytochrome P450 Collagen	Inflammation/Immunology
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis .

Fluorene 1 Publications Verification	Environmental Pollutants Fluorescent Dye TNF Receptor Interleukin Related SOD Reactive Oxygen Species (ROS)	Inflammation/Immunology
Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .

Rodatristat ethyl KAR5585	Tryptophan Hydroxylase 5-HT Receptor	Cardiovascular Disease
Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH) .

Cyanine 5 NHS ester tetrafluoroborate	Fluorescent Dye	Others
Cyanine 5 NHS ester tetrafluoroborate (Compound Cy5) is a cyanine dye that is used to in fluorescence detection of macromolecules. Cyanine 5 NHS ester tetrafluoroborate exhibits an excitation wavelength of 638 nm .

Sofpironium bromide BBI 4000	mAChR	Neurological Disease
Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes .

NTP42	Prostaglandin Receptor	Cardiovascular Disease
NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC₅₀ of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca ²⁺] mobilization following stimulation of cells with the alternative TP agonist U46619 . NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH) .

Acenaphthylene 1 Publications Verification	Environmental Pollutants Drug Intermediate	Others
Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter .

Chrysene 1 Publications Verification	Environmental Pollutants	Cancer
Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .

Cibotercept KER-012	TGF-beta/Smad	Inflammation/Immunology
Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH .

Aviptadil acetate 2 Publications Verification Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

Drpitor1a	Dynamin Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer ^[1]

PRX-08066	5-HT Receptor p38 MAPK TGF-β Receptor FGFR Apoptosis Caspase	Cardiovascular Disease Neurological Disease Cancer
PRX-08066 is a selective and orally active 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist with a K_i of 3.4 nM. PRX-08066 inhibits the MAPK pathway, 5-HT release and fibrotic factor (TGFβ1, CTGF and FGF2) expression. PRX-08066 inhibits the proliferation of KRJ-I cells and induces apoptosis (caspase-3 activation). PRX-08066 inhibits pulmonary vascular remodeling. PRX-08066 can be used of pulmonary Arterial Hypertension (PAH) and neuroendocrine tumor (NET) .

Phenamil methanesulfonate	Sodium Channel TRP Channel	Metabolic Disease Inflammation/Immunology
Phenamil methanesulfonate, an analog of Amiloride (HY-B0285), is a more potent and less reversible epithelial sodium channel (ENaC) blocker with an IC₅₀ of 400 nM . Phenamil methanesulfonate is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca ²⁺ transport with an IC₅₀ of 140 nM in a Ca ²⁺ uptake assay . Phenamil methanesulfonate is an intriguing small molecule to promote bone repair by strongly activating BMP signaling pathway . Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease .

Sapropterin dihydrochloride (Standard) (6R)-BH4 dihydrochloride (Standard); (6R)-Tetrahydro-L-biopterin dihydrochloride (Standard)	Endogenous Metabolite Reference Standards	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride (Standard) is the analytical standard of Sapropterin dihydrochloride (HY-A0124A) . This product is intended for research and analytical applications. Sapropterin dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

Smurf1-IN-5	E1/E2/E3 Enzyme	Cardiovascular Disease
Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH) .

Sapropterin (6R)-BH4; (6R)-Tetrahydro-L-biopterin	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE) .

TPN171	Phosphodiesterase (PDE)	Cardiovascular Disease
TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC₅₀ of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH) .

CB7993113	Aryl Hydrocarbon Receptor	Cancer
CB7993113 is a potent AHR antagonist, with an IC₅₀ of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively .

Macitentan (Standard) ACT-064992 (Standard)	Reference Standards Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Macitentan (Standard) is the analytical standard of Macitentan. This product is intended for research and analytical applications. Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

1-Hydroxy-2-naphthoic acid	Bacterial Drug Intermediate	Infection
1-Hydroxy-2-naphthoic acid is a ubiquitous bicyclic intermediate metabolite in the microbial degradation process of polycyclic aromatic hydrocarbons (PAHs). 1-Hydroxy-2-naphthoic acid can be converted into 1,2-naphthalenediol, which enters the naphthalene degradation pathway and participates in the tricarboxylic acid (TCA) cycle to achieve complete mineralization .

Nonanoylcarnitine C9 carnitine	Endogenous Metabolite	Cardiovascular Disease Cancer
Nonanoylcarnitine is a metabolite associated with chronic environmental exposure to polycyclic aromatic hydrocarbons (PAH) and fragmented QRS waves in acute myocardial infarction. Nonanoylcarnitine can be used as a potential biomarker for the metabolic outcome of PAH exposure and the prognosis of acute myocardial infarction .

Lunamarine	Bacterial Phosphodiesterase (PDE)	Metabolic Disease
Lunamarine is a inhibitor of PDE5 with BBB permeability. Lunamarine can be used in the reseach of Pulmonary Arterial Hypertension (PAH) and Erectile Dysfunction (ED) .

PF-543 hydrochloride Sphingosine Kinase 1 Inhibitor II hydrochloride	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy .

Benz[a]anthracene Tetraphene	Environmental Pollutants Aryl Hydrocarbon Receptor	Others
Benz[a]anthracene (Tetraphene) (Compound 92) is a ligand for the aryl hydrocarbon receptor (AhR) with a pIC₅₀ of 7.319. Benz[a]anthracene is a polycyclic aromatic hydrocarbon (PAH) that can be detected in spruce needles near aluminum smelters .

Benzo[k]fluoranthene	Environmental Pollutants Endogenous Metabolite	Others
Benzo[k]fluoranthene is a polycyclic aromatic hydrocarbon (PAH) that is carcinogenic and genotoxic .

Phenanthrene (Standard)	Reference Standards Apoptosis	Inflammation/Immunology Cancer
Phenanthrene (Standard) is the analytical standard of Phenanthrene. This product is intended for research and analytical applications. Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .

Triphenylene	Drug Intermediate	Others
Triphenylene is a highly symmetrical polycyclic aromatic hydrocarbon. Triphenylene shows no carcinogenic activity in mouse skin application experiments. Triphenylene can be used as a drug intermediate for the synthesis of triphenyl polycyclic aromatic hydrocarbons (PAHs) .

Hsp110-STAT3 PPI-IN-1	HSP STAT	Cardiovascular Disease
Row174336 (compound 29) is a potent inhibitor of Hsp110-STAT3 interaction that shows antiproliferative activity against HPAEC cell line, with the IC₅₀ of 22.67 μM .

Fluorene (Standard)	Fluorescent Dye Reference Standards	Others
Fluorene (Standard) is the analytical standard of Fluorene. This product is intended for research and analytical applications. Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative?can be used as a precursor to fluorene-based dyes .

Cat. No.	Nom du produit	Type

HY-103609

Pyrene

1 Publications Verification

Benzo[def]phenanthrene

Fluorescent Dyes

Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

HY-134620

Cyanine 5 NHS ester tetrafluoroborate	Fluorescent Dyes
Cyanine 5 NHS ester tetrafluoroborate (Compound Cy5) is a cyanine dye that is used to in fluorescence detection of macromolecules. Cyanine 5 NHS ester tetrafluoroborate exhibits an excitation wavelength of 638 nm .

HY-D1549

o-Pah	Fluorescent Dyes
o-Pah is a BODIPY derivative with an -NH₂ and -OH substituted meso-Ph group. o-Pah exhibits metal-induced J-aggregation in the presence of Cu ²⁺ and a specific fluorescence enhancement for Hg ²⁺ (Ex/Em=483/(495-600) nM) .

HY-103609R

Pyrene (Standard)

Benzo[def]phenanthrene (Standard)

Fluorescent Dyes

Pyrene (Standard) is the analytical standard of Pyrene. This product is intended for research and analytical applications. Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

Cat. No.	Nom du produit	Target	Research Area

HY-P0012

Aviptadil 2 Publications Verification Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

HY-P0012A

Aviptadil acetate 2 Publications Verification Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

HY-P3242

Mad1 (6-21)	HDAC	Neurological Disease
Mad1 (6-21) is the 6-21 fragment of Mad1 protein. Mad1 (6-21) binds to mammalian Sin3A PAH2 with a K_d of ~29 nM .

HY-P3242A

Mad1 (6-21) TFA	HDAC	Neurological Disease
Mad1 (6-21) TFA is the 6-21 fragment of Mad1 protein. Mad1 (6-21) TFA binds to mammalian Sin3A PAH2 with a K_d of ~29 nM .

Cat. No.	Nom du produit	Target	Research Area	Image

HY-P990733

Cibotercept KER-012	TGF-beta/Smad	Inflammation/Immunology
Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH .

HY-P992008

PF-07868489	TGF-β Receptor	Cardiovascular Disease
PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9. PF-07868489 can be used for the research of pulmonary arterial hypertension (PAH). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

Species:	Human (2)
Tag:	His (2) MBP (1) Flag (1)
Source:	HEK293 (1) Sf9 insect cells (1)

Cat. No.	Compare	Nom du produit	Species	Source	Image

HY-P73733

	PAH Protein, Human (D415N, sf9, His) 1 Publications Verification Phenylalanine-4-hydroxylase; PAH	Human	Sf9 insect cells
	PAH protein is a key enzyme involved in amino acid metabolism. Its main function is to catalyze the hydroxylation of L-phenylalanine and convert it into L-tyrosine. PAH Protein, Human (D415N, sf9, His) is the recombinant human-derived PAH protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P704004

	SLC22A6 Protein, Human (HEK293, His, MBP, FLAG) SLC22A6; Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; Hroat1	Human	HEK293
	The SLC22A6 protein acts as a Na(+)-independent organic anion (OA)/dicarboxylic acid antiporter and promotes renal elimination by transporting OA from proximal tubule cells into the urine. It transports coenzymes (BH4, BH2, septopterin) and determines blood biopterin levels as well as prostaglandins, cyclic nucleotides, tryptophan metabolites, uremic toxins (e.g. indoxyl sulfate) and xenobiotics (e.g. ochratoxin). SLC22A6 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC22A6 protein, expressed by Sf9 insect cells .

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Cat. No.	Nom du produit	Chemical Structure

HY-B1727S

Phenanthrene-d10
Phenanthrene-d₁₀ is the deuterium labeled Phenanthrene. Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) and has been frequently used as an indicator for monitoring PAH contaminated matrices . Phenanthrene induces oxidative stress and inflammation .

HY-W014075S

1-Hydroxypyrene-d9
1-Hydroxypyrene-d₉ is the deuterium labeled 1-Hydroxypyrene (HY-W014075). 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis .

HY-14184S

Macitentan-d4
Macitentan-d₄ is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

HY-W013570S

Acenaphthylene-d8
Acenaphthylene-d₈ is the deuterium labeled Acenaphthylene . Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter .

HY-144856S1

Sapropterin-d3
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-W777456

Phenanthrene-13C6
Phenanthrene- ¹³C₆ is the ¹³C labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .

HY-121107S

Chrysene-d12
Chrysene-d₁₂ is the deuterium labeled Chrysene. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .

HY-W778162

Phenanthrene-13C2
Phenanthrene- ¹³C₂ is the ¹³C-labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .

HY-W026772S

Fluorene-d10
Fluorene-d₁₀ is the deuterium labeled Fluorene. Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative?can be used as a precursor to fluorene-based dyes .

HY-167906S

Hexadecyl 2-((4-Nitrophenyl)thio)acetate-13C2
Hexadecyl 2-((4-Nitrophenyl)thio)acetate- ¹³C₂ is the ¹³C-labeled Lunamarine (HY-167906). Lunamarine is a inhibitor of PDE5 with BBB permeability. Lunamarine can be used in the reseach of Pulmonary Arterial Hypertension (PAH) and Erectile Dysfunction (ED) .

HY-W026772S1

Fluorene-d8

Fluorene-d₈ is the deuterium labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .

HY-W777458

Fluorene-13C6

Fluorene- ¹³C₆ is the ¹³C-labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .

HY-109013S

Sofpironium-13C,d3 bromide

Sofpironium- ¹³C,d₃ bromide (BBI 4000- ¹³C,d₃) is the deuterium and ¹³C-labeled Sofpironium bromide (HY-109013). Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes .

Host:	Mouse (1) Rabbit (3)
Reactivity:	Human (2) Rat (2) Mouse (3) human (1)
Application:	IHC-P (2) ICC/IF (1) IF-Tissue (2) IP (1) IHC-F (1) WB (4) ELISA (1)
Isotype:	IgG (3) IgG1 (1)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Nom du produit	Application	Reactivity	Image

HY-P87644

	PAH Antibody (YA7328)	WB, IHC-P, IHC-F, IF-Tissue	Mouse
	PAH Antibody (YA7328) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAH.

HY-P81951

	PAH Antibody (YA1696) Phe-4-monooxygenase	WB	Human, Mouse, Rat
	PAH Antibody (YA1696) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAH.

HY-P81951A

	PAH Antibody (YA1696)(PBS only) Phe-4-monooxygenase	WB	Human, Mouse, Rat
	PAH Antibody (YA1696) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAH.

HY-P89663

	OAT1 Antibody (YA9007) OAT1, PAHT, SLC22A6, Solute carrier family 22 member 6, Organic anion transporter 1, PAH transporter, Renal organic anion transporter 1, hOAT1, hPAHT, hROAT1	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	OAT1 Antibody (YA9007) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OAT1.

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Cat. No.	Nom du produit		Classification

HY-RS09979

PAH Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PAH Human Pre-designed siRNA Set A contains three designed siRNAs for PAH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-172508

Perylene dU phosphoramidite		Phosphoramidites Uracil
Perylene dU phosphoramidite is a bright and extremely photostable fluorescent polycyclic aromatic hydrocarbon (PAH) label with a quantum yield approaching quantitative. Due to the low lifetime of fluorescence, this probe does not form excimers.With this phosphoramidite, perylene can be introduced into DNA by automated oligonucleotide synthesis.

HY-RS17018

Pah Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pah Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pah gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23461

Pah Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pah Rat Pre-designed siRNA Set A contains three designed siRNAs for Pah gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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PAH

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