2. TGF-beta/Smad
  3. TGF-β Receptor
  4. PF-07868489

PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9. PF-07868489 can be used for the research of pulmonary arterial hypertension (PAH). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

For research use only. We do not sell to patients.

PF-07868489

PF-07868489 Chemical Structure

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This product is a controlled substance and not for sale in your territory.

PF-07868489 Related Antibodies

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Description

PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9. PF-07868489 can be used for the research of pulmonary arterial hypertension (PAH). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
In Vitro

The BMP-9/GDF-2 protein is a potent angiogenesis inhibitor that selectively signals through AVRL1 in endothelial cells. Its signaling pathway requires the TGF-β co-receptor endoglin/ENG for efficient activation of SMAD1.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-07868489 Related Antibodies
Clinical Trial
Gene ID

2658  [NCBI]

Accession

Q9UK05
Target

GDF-2/BMP-9
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[PF-07868489]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-07868489 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-07868489PF07868489PF 07868489TGF-β ReceptorTransforming growth factor beta receptorsGDF2BMP-9pulmonary arterial hypertensionInhibitorinhibitorinhibit

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