1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. PDE10A-IN-2 hydrochloride

PDE10A-IN-2 hydrochloride 

Cat. No.: HY-131973
Handling Instructions

PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 2.8 nM. PDE10A-IN-2 hydrochloride shows selectivity of >3500-fold against other PDE subtypes. PDE10A-IN-2 hydrochloride can be used for pulmonary arterial hypertension (PAH) research.

For research use only. We do not sell to patients.

PDE10A-IN-2 hydrochloride Chemical Structure

PDE10A-IN-2 hydrochloride Chemical Structure

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Description

PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 2.8 nM. PDE10A-IN-2 hydrochloride shows selectivity of >3500-fold against other PDE subtypes. PDE10A-IN-2 hydrochloride can be used for pulmonary arterial hypertension (PAH) research[1].

IC50 & Target[1]

PDE10A

2.8 nM (IC50)

In Vivo

PDE10A-IN-2 hydrochloride (compound 14 3HCL; 2.5 mg/kg; oral administration; daily; for 3 weeks) treatment decreases the typical symptoms of PAH in rats[1].
In Sprague-Dawley rats, the pharmacokinetic study of PDE10A-IN-2 hydrochloride (compound 14 3HCL; 10 mg/kg) shows the oral bioavailability up to ∼50%, and the T1/2 is 5.2 hours (p.o.), and the Cmax is 272 ng/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wister rats (6 weeks, 160-180 g) injected with Monocrotaline[1]
Dosage: 2.5 mg/kg
Administration: Oral administration; daily; for 3 weeks
Result: Decreased symptoms of the pulmonary arterial hypertension (PAH) rats.
Molecular Weight

627.05

Formula

C₃₃H₃₈Cl₃N₅O

SMILES

CN1CCN(CCCOC2=CC(N3C(/C=C/C4=C5N=CC=CC5=CC=C4)=NC6=CC(C)=CC=C36)=CC=C2)CC1.[H]Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PDE10A-IN-2Phosphodiesterase (PDE)PDE10APAHoralInhibitorinhibitorinhibit

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Product Name:
PDE10A-IN-2 hydrochloride
Cat. No.:
HY-131973
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