CB7993113
Based on 1 Customer Validation
CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 819827-50-4
- Formula: C15H10BrNO5
- Molecular Weight:364.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CB7993113 exhibits no toxicity when added at concentrations at least up to 20 μM to several human cells including HepG2 hepatoma cells, BP1, D3, Hs578T, or MDA-MB-231 breast cancer cells, and primary human-induced pluripotent stem cells[1].
CB7993113 significantly reduces the invasive phenotype of ER-/PR-/HER2- breast cancer cells in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 819827-50-4
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Appearance Solid
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Molecular Weight 364.15
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Formula C15H10BrNO5
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Color White to yellow
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SMILES
O=C(N)COC1=C(C2=CC=C(Br)O2)OC3=CC=CC=C3C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (137.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7461 mL | 13.7306 mL | 27.4612 mL | 68.6530 mL |
| 5 mM | 0.5492 mL | 2.7461 mL | 5.4922 mL | 13.7306 mL | |
| 10 mM | 0.2746 mL | 1.3731 mL | 2.7461 mL | 6.8653 mL | |
| 15 mM | 0.1831 mL | 0.9154 mL | 1.8307 mL | 4.5769 mL | |
| 20 mM | 0.1373 mL | 0.6865 mL | 1.3731 mL | 3.4327 mL | |
| 25 mM | 0.1098 mL | 0.5492 mL | 1.0984 mL | 2.7461 mL | |
| 30 mM | 0.0915 mL | 0.4577 mL | 0.9154 mL | 2.2884 mL | |
| 40 mM | 0.0687 mL | 0.3433 mL | 0.6865 mL | 1.7163 mL | |
| 50 mM | 0.0549 mL | 0.2746 mL | 0.5492 mL | 1.3731 mL | |
| 60 mM | 0.0458 mL | 0.2288 mL | 0.4577 mL | 1.1442 mL | |
| 80 mM | 0.0343 mL | 0.1716 mL | 0.3433 mL | 0.8582 mL | |
| 100 mM | 0.0275 mL | 0.1373 mL | 0.2746 mL | 0.6865 mL |
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