1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Sofpironium bromide

Sofpironium bromide (Synonyms: BBI 4000)

Cat. No.: HY-109013
Handling Instructions

Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes.

For research use only. We do not sell to patients.

Sofpironium bromide Chemical Structure

Sofpironium bromide Chemical Structure

CAS No. : 1628106-94-4

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Solution
10 mM * 1 mL in DMSO USD 466 Ask For Quote & Lead Time
Solid
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10 mg USD 800 Ask For Quote & Lead Time
25 mg USD 1650 Ask For Quote & Lead Time
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100 mg USD 3800 Ask For Quote & Lead Time

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Description

Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes[1].

In Vitro

Sofpironium bromide is metabolized mainly through non-enzymatic hydrolysis, and also through oxidative metabolism via CYP2D6 and CYP3A4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sofpironium bromide exhibits anticholinergic activity by inhibiting the contractile activity of guinea pig ileal tissue in a concentration-dependent manner. In a rat model, Sofpironium bromide reduces footpad sweating induced by Pilocarpine (a muscarinic receptor agonist)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

470.40

Formula

C₂₂H₃₂BrNO₅

CAS No.
SMILES

CCOC(C[N+](C)(CC1)C[[email protected]@H]1OC([[email protected]@](C2CCCC2)(C3=CC=CC=C3)O)=O)=O.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SofpironiumBBI 4000BBI4000BBI-4000mAChRMuscarinic acetylcholine receptorhyperhidrosisanticholinergicM3muscarinicCYP2D6CYP3A4Inhibitorinhibitorinhibit

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Product Name:
Sofpironium bromide
Cat. No.:
HY-109013
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