1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. ET receptor antagonist 1

ET receptor antagonist 1 (compound 16h) is an orally active ET receptor antagonist (IC50=0.18 nM), which can be used for research in pulmonary arterial hypertension (PAH). ET receptor antagonist 1 attenuates monocrotaline (HY-N0750) induced PAH in rat model.

For research use only. We do not sell to patients.

ET receptor antagonist 1 Chemical Structure

ET receptor antagonist 1 Chemical Structure

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Description

ET receptor antagonist 1 (compound 16h) is an orally active ET receptor antagonist (IC50=0.18 nM), which can be used for research in pulmonary arterial hypertension (PAH). ET receptor antagonist 1 attenuates monocrotaline (HY-N0750) induced PAH in rat model[1].

IC50 & Target

IC50: 0.18 nM (ET receptor)[1]

In Vivo

ET receptor antagonist 1 (compound 16h) (150 mg/kg/d, 300 mg/kg/d; po; 48 h following MCT administration, for 21-26 d) results significant reduction in mPAP, and decreases the levels of HIF1α, ANP, and TNNI3 in MCT-exposed rats. And shows antioxidant profile and inhibits lipid peroxidation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

459.52

Formula

C21H25N5O5S

SMILES

CC(CCOC(N=C1C2=NC=CC=N2)=C(C(NS(=O)(C)=O)=N1)OC3=CC=CC=C3OC)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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ET receptor antagonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ET receptor antagonist 1
Cat. No.:
HY-155737
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