2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. ET receptor antagonist 2

ET receptor antagonist 2 (compound 16j) is an orally active ET receptor antagonist (IC50=0.22 nM), which can be used for research in pulmonary arterial hypertension (PAH). ET receptor antagonist 2 attenuates monocrotaline (HY-N0750) induced PAH in rat model.

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ET receptor antagonist 2 Chemical Structure

ET receptor antagonist 2 Chemical Structure

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ET receptor antagonist 2 Related Antibodies

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Description

ET receptor antagonist 2 (compound 16j) is an orally active ET receptor antagonist (IC50=0.22 nM), which can be used for research in pulmonary arterial hypertension (PAH). ET receptor antagonist 2 attenuates monocrotaline (HY-N0750) induced PAH in rat model[1].

IC50 & Target

IC50: 0.22 nM (ET receptor)[1]
In Vivo

ET receptor antagonist 2 (compoud 16j) (150 mg/kg/d, 300 mg/kg/d; po; 48 h following MCT administration, for 21-26 d) results significant reduction in mPAP, and decreases the levels of HIF1α, ANP, and TNNI3 in MCT-exposed rats. And shows antioxidant profile and inhibits lipid peroxidation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

471.53

Formula

C22H25N5O5S
SMILES

CS(=O)(NC1=NC(C2=NC=CC=N2)=NC(OCC/C=C/CC)=C1OC3=CC=CC=C3OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ET receptor antagonist 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ET receptor antagonist 2ET receptor antagonist2ET receptor antagonist-2Estrogen Receptor/ERRBosentan derivativesEndothelin receptorHistological analysisMolecular dockingPulmonary arterial hypertensionInhibitorinhibitorinhibit

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ET receptor antagonist 2
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HY-155738
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