APJ receptor agonist 10 free base

Name: APJ receptor agonist 10 free base
Brand: MedChemExpress
SKU: HY-170419A
Rating: 4.5 (0 reviews)

Cat. No.: HY-170419A Pureza: 99.27%: Ficha de datos
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APJ receptor agonist 10 free base is an agonist of the APJ Receptor. APJ receptor agonist 10 free base can be used for research on pulmonary arterial hypertension.

Para uso exclusivo en investigación. No vendemos a pacientes.

APJ receptor agonist 10 free base Estructura química

No. CAS : 2415197-87-2

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	Obtener un presupuesto
200 mg	Obtener un presupuesto

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Based on 1 Customer Validation

Other Forms of APJ receptor agonist 10 free base:

APJ receptor agonist 10 In-stock

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

APJ receptor agonist 10 free base is an agonist of the APJ Receptor. APJ receptor agonist 10 free base can be used for research on pulmonary arterial hypertension^[1].

In Vivo

APJ receptor agonist 10 free base (Compound I choline salt) (30 mg/kg; oral; single dose) demonstrates significantly higher oral bioavailability than Compound I free acid Form A in male Beagle dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

470.50

Fòrmula

C₂₁H₂₂N₆O₅S

No. CAS

2415197-87-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(NC1=CN=C(N=C(N2C3=C(OC)C=CC=C3OC)C4=CC=CC(OCC)=N4)C2=N1)(C)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 25 mg/mL (53.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1254 mL	10.6270 mL	21.2540 mL
5 mM	0.4251 mL	2.1254 mL	4.2508 mL
10 mM	0.2125 mL	1.0627 mL	2.1254 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.27%

Select Batch:

Ficha de datos (274 KB) SDS (251 KB)

COA (254 KB) HNMR (267 KB) LCMS (94 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Libo Chen, et al. Salts and solid forms of a compound having apj receptor activity. WO2024099382A1. 2023.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1254 mL	10.6270 mL	21.2540 mL	53.1350 mL
	5 mM	0.4251 mL	2.1254 mL	4.2508 mL	10.6270 mL
	10 mM	0.2125 mL	1.0627 mL	2.1254 mL	5.3135 mL
	15 mM	0.1417 mL	0.7085 mL	1.4169 mL	3.5423 mL
	20 mM	0.1063 mL	0.5313 mL	1.0627 mL	2.6567 mL
	25 mM	0.0850 mL	0.4251 mL	0.8502 mL	2.1254 mL
	30 mM	0.0708 mL	0.3542 mL	0.7085 mL	1.7712 mL
	40 mM	0.0531 mL	0.2657 mL	0.5313 mL	1.3284 mL
	50 mM	0.0425 mL	0.2125 mL	0.4251 mL	1.0627 mL