APJ receptor agonist 10

Name: APJ receptor agonist 10
Brand: MedChemExpress
SKU: HY-170419
Rating: 4.5 (0 reviews)

Cat. No.: HY-170419 Purity: 99.88%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

APJ receptor agonist 10 is an agonist of the APJ Receptor. APJ receptor agonist 10 can be used for research on pulmonary arterial hypertension.

For research use only. We do not sell to patients.

APJ receptor agonist 10 Chemical Structure

CAS No. : 3037373-19-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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100 mg	Get quote

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Other Forms of APJ receptor agonist 10:

APJ receptor agonist 10 free base In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

APJ receptor agonist 10 is an agonist of the APJ Receptor. APJ receptor agonist 10 can be used for research on pulmonary arterial hypertension^[1].

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_0-last
Dog^[1]	30 mg/kg	p.o.	73850 ng/mL	2.0-4.0 h	1115424 ng·h/mL
Dog^[1]	30 mg/kg	p.o.	11915 ng/mL	4.0 h	145309 ng·h/mL

In Vivo

APJ receptor agonist 10 (Compound I choline salt) (30 mg/kg; oral; single dose) demonstrates significantly higher oral bioavailability than Compound I free acid Form A in male Beagle dogs, with suspension and capsule formulations showing mean AUC_last values of 1115424 h·ng/mL and 145309 h·ng/mL, respectively, at a 30 mg/kg oral dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

574.67

Formula

C₂₆H₃₆N₇O₆S⁺

CAS No.

3037373-19-3

Appearance

Solid

Color

White to light yellow

SMILES

O=S(NC1=CN=C(N=C(N2C3=C(OC)C=CC=C3OC)C4=CC=CC(OCC)=N4)C2=N1)(C)=O.OCC[N+](C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (174.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7401 mL	8.7006 mL	17.4013 mL
5 mM	0.3480 mL	1.7401 mL	3.4803 mL
10 mM	0.1740 mL	0.8701 mL	1.7401 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (249 KB) HNMR (379 KB) RP-HPLC (253 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Libo Chen, et al. Salts and solid forms of a compound having apj receptor activity. WO2024099382A1. 2023.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7401 mL	8.7006 mL	17.4013 mL	43.5032 mL
	5 mM	0.3480 mL	1.7401 mL	3.4803 mL	8.7006 mL
	10 mM	0.1740 mL	0.8701 mL	1.7401 mL	4.3503 mL
	15 mM	0.1160 mL	0.5800 mL	1.1601 mL	2.9002 mL
	20 mM	0.0870 mL	0.4350 mL	0.8701 mL	2.1752 mL
	25 mM	0.0696 mL	0.3480 mL	0.6961 mL	1.7401 mL
	30 mM	0.0580 mL	0.2900 mL	0.5800 mL	1.4501 mL
	40 mM	0.0435 mL	0.2175 mL	0.4350 mL	1.0876 mL
	50 mM	0.0348 mL	0.1740 mL	0.3480 mL	0.8701 mL
	60 mM	0.0290 mL	0.1450 mL	0.2900 mL	0.7251 mL
	80 mM	0.0218 mL	0.1088 mL	0.2175 mL	0.5438 mL
	100 mM	0.0174 mL	0.0870 mL	0.1740 mL	0.4350 mL