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SEA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Aminopeptidase (1) Apoptosis (1) Arp2/3 Complex (2) Bacterial (11) Biochemical Assay Reagents (4) Caspase (2) Cholinesterase (ChE) (3) DNA/RNA Synthesis (2) Drug Derivative (5) Endogenous Metabolite (9) Environmental Pollutants (5) ERK (2) Fluorescent Dye (1) Fungal (7) Glycosidase (1) GnRH Receptor (2) HIV (1) HSV (1) Insecticide (3) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (3) JNK (2) Liposome (1) Lipoxygenase (2) Mitochondrial Metabolism (2) mRNA (2) Mucin (1) Na+/Ca2+ Exchanger (2) NF-κB (2) NO Synthase (4) P2X Receptor (1) p38 MAPK (2) Parasite (6) PARP (1) Potassium Channel (2) Reactive Oxygen Species (ROS) (2) Reference Standards (5) Small Interfering RNA (siRNA) (4) Sodium Channel (5) TNF Receptor (2) Topoisomerase (1) Transmembrane Glycoprotein (2) Tyrosinase (1) α-synuclein (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (6) Endocrinology (2) Infection (21) Inflammation/Immunology (12) Metabolic Disease (4) Neurological Disease (19)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Liposome (1) mRNA (2) Mouse Pre-designed siRNA Sets (1) Reporter Genes (2) Human Pre-designed siRNA Sets (3) siRNAs (4)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1207

Urethane 4 Publications Verification Ethyl carbamate; Carbamic acid ethyl ester; Ethylurethane	Environmental Pollutants Bacterial Parasite	Infection Neurological Disease Cancer
Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro .

HY-16929

Latrunculin A 10+ Cited Publications LAT-A	Arp2/3 Complex	Cancer
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-D0914

Fast Green FCF FD&C Green No. 3; Food green 3; C.I. 42053	Environmental Pollutants α-synuclein	Neurological Disease
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF inhibits α-synuclein aggregation, as well as Aβ and P2X4 receptor, and TLR4/Myd88/NF-κB. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function .

HY-15515

SEA0400 Maximum Cited Publications 19 Publications Verification	Na+/Ca2+ Exchanger	Cardiovascular Disease
SEA0400 is a novel and selective inhibitor of the Na ⁺-Ca ²⁺ exchanger (NCX), inhibiting Na ⁺-dependent Ca ²⁺ uptake in cultured neurons, astrocytes, and microglia with IC₅₀s of from 5 to 33 nM.

HY-N7059

Lactobionic acid	Bacterial Reactive Oxygen Species (ROS)	Infection
Lactobionic acid is a bionic acid that can be naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties. Lactobionic acid can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .

HY-B1162

Sulisobenzone 1 Publications Verification Benzophenone-4	Environmental Pollutants Biochemical Assay Reagents	Metabolic Disease
Sulisobenzone (Benzophenone-4) is a benzophenone-type UV filter. Sulisobenzone can act as a endocrine disrupting compound. Sulisobenzone disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function. Sulisobenzone thyroid hormone biosynthesis and induces oxidative stress .

HY-127170

3-Hydroxycoumarin	Lipoxygenase Tyrosinase	Metabolic Disease Inflammation/Immunology
3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase with an IC₅₀ for recombinant human tyrosinase (rHT) of 26 μM, and a K_i of 3.39 μM; its IC₅₀ for LOX is 9.5 μM. 3-Hydroxycoumarin has DPPH free radical scavenging activity (IC₅₀ = 31.2 μM). 3-Hydroxycoumarin has photoprotective effects on sea urchin zygotes and embryos .

HY-W034344

Sodium methanesulfonate	Biochemical Assay Reagents	Others
Sodium methanesulfonate is a hygroscopic atmospheric aerosol, which typically forms from the reaction of methanesulfonic acid with sodium chloride or sea salt particles. Sodium methanesulfonate can serve as a substrate for oxidation reactions, undergoing heterogeneous oxidation by hydroxyl radicals at the air-aerosol interface, thereby initiating subsequent aerosol-phase chain reactions. Sodium methanesulfonate exhibits significant temperature-dependent deliquescence and efflorescence properties; particularly at lower temperatures relevant to the troposphere, its deliquescence and efflorescence relative humidity increase accordingly .

HY-17592A

Bithionol (sulfoxide) 2 Publications Verification	Parasite	Infection
Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite infection, such as paragonimiasis, flukes andcestodes infection .

HY-113000

Cetoleic acid	Endogenous Metabolite	Cardiovascular Disease
Cetoleic acid is a long-chain monounsaturated fatty acid found in deep-sea fish. Cetoleic acid can promote the synthesis of ALA in human HepG2 cells and EPA in vitro in salmon liver cells, affecting cholesterol levels in rodents. Cetoleic acid has potential applications in cardiovascular disease research .

HY-B1207S

Urethane-d5 Ethyl carbamate-d₅; Carbamic acid ethyl ester-d₅; Ethylurethane-d₅	Bacterial Parasite	Infection Neurological Disease Cancer
Urethane-d₅ is the deuterium labeled Urethane. Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro .

HY-P1346

APETx2	Sodium Channel	Neurological Disease Inflammation/Immunology
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

HY-P1346A

APETx2 TFA	Sodium Channel	Neurological Disease Inflammation/Immunology
APETx2 TFA, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

HY-108960

PPADS	P2X Receptor Interleukin Related	Neurological Disease
PPADS is a P2X receptor (P2X Receptor) antagonist and a reversible competitive antagonist of NAADP receptors, with IC₅₀ values of 68 nM (P2X1) and 214 nM (P2X3), respectively. PPADS alleviates pain-related behaviors in the central and peripheral nervous systems of mice after peripheral neuropathy, inhibits the overproduction of IL-1β, IL-6, iNOS and nNOS, and suppresses the hydrolytic activity of extracellular ATPase. PPADS blocks ATP-mediated inward currents on recombinant rat P2X₁ and P2X₃ receptors, and inhibits purinergic nerve stimulation-induced contraction of rabbit bladder detrusor muscle. PPADS is applicable to research related to neuropathic pain .

HY-P3071

ShK toxin Stichodactyla helianthus neurotoxin	Potassium Channel	Neurological Disease Inflammation/Immunology
ShK toxin blocks voltage-dependent potassium channel (K_v1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .

HY-123063

Petromyzonol 5α-Petromyzonol; 5α-PZ	Others	Others
Petromyzonol (5α-Petromyzonol) is a tetrahydroxy stearol produced by the bile of sea lamprey larvae from the bile acid precursor acetylcholic acid. Petromyzonol sulfate acts as a pheromone and oviposition chemical attractant .

HY-B1207R

Urethane (Standard) Ethyl carbamate (Standard); Carbamic acid ethyl ester (Standard); Ethylurethane (Standard)	Reference Standards Bacterial Parasite	Infection Neurological Disease Cancer
Urethane (Standard) is the analytical standard of Urethane. This product is intended for research and analytical applications. Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro .

HY-P99436

Anatumomab mafenatox ABR-214936	Transmembrane Glycoprotein	Cardiovascular Disease Inflammation/Immunology Cancer
Anatumomab mafenatox (ABR-214936) is a 73 KDa recombinant protein to recognize the tumor-associated antigen 5T4, which is widely expressing in malignancy. Anatumomab mafenatox is between a modified form of SEA and a murine Fab. The main side effects of Anatumomab mafenatox are reported to include fever, low blood pressure, pain, nausea and drowsiness .

HY-15515R

SEA0400 (Standard)	Na+/Ca2+ Exchanger Reference Standards	Cardiovascular Disease
SEA0400 (Standard) is the analytical standard of SEA0400. This product is intended for research and analytical applications. SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.

HY-127170R

3-Hydroxycoumarin (Standard)	Lipoxygenase Reference Standards	Others
3-Hydroxycoumarin (Standard) is the analytical standard of 3-Hydroxycoumarin. This product is intended for research and analytical applications. 3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage .

HY-114899

Azamethiphos	Environmental Pollutants Cholinesterase (ChE) Insecticide	Infection Neurological Disease
Azamethiphos is an acetylcholinesterase inhibitor and insecticide. Azamethiphos covalently binds to acetylcholinesterase via phosphorylation, inhibits its activity, causes acetylcholine to accumulate in cholinergic synapses, triggers uncontrolled excitation of cholinergic sites, induces paralysis and leads to death. Azamethiphos can be used as a bath insecticide in salmonid aquaculture to control sea lice infestations, and it exerts acute toxicity to European lobster larvae, including mortality and movement disorders .

HY-RS13089

SLC25A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLC25A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC25A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC25A1 Human Pre-designed siRNA Set A SLC25A1 Human Pre-designed siRNA Set A

HY-N2225

Isorhamnetin-3-O-sophoroside-7-O-rhamnoside	Others	Infection
Isorhamnetin-3-O-sophoroside-7-O-rhamnoside, the major flavonol glycoside, is isolated from sea buckthorn (Hippopha rhamnoides). Isorhamnetin-3-O-sophoroside-7-O-rhamnoside has the algicidal activity against the growth of the harmful microalgae .

HY-P3071A

ShK toxin TFA Stichodactyla helianthus neurotoxin TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
ShK toxin TFA (Stichodactyla helianthus neurotoxin TFA) is a neurotoxin. ShK toxin TFA blocks voltage-dependent potassium channel (K_v1.3 channel). ShK toxin TFA can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin TFA competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin TFA suppresses K ⁺ currents in cultured rat dorsal root ganglion neurons. ShK toxin TFA also inhibits T lymphocyte proliferation .

HY-P0245

Speract	Mitochondrial Metabolism	Metabolic Disease
Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.

HY-41314

Ethyl 3-methyl-2-butenoate	Endogenous Metabolite	Others
Ethyl 3-methyl-2-butenoate is a volatile compound that can be isolated from sea buckthorn .

HY-P10564

Pardaxin P 4	Bacterial	Infection
Pardaxin P 4 is an antimicrobial peptide found in the secretions of Red Sea Moses sole. Pardaxin P 4 acts as a biomembrane perforator that can interact with phospholipid bilayers of different compositions and induce cytotoxicity and pore formation. Pardaxin P 4 can be used in the research of antimicrobial drugs .

HY-P11214

Hydrostatin-TL1 H-TL1	TNF Receptor Integrin NF-κB ERK p38 MAPK JNK Interleukin Related	Inflammation/Immunology
Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research .

HY-N7059R

Lactobionic acid (Standard)	Reference Standards Bacterial Reactive Oxygen Species (ROS)	Infection
Lactobionic acid (Standard) is an analytical standard for lactobionic acid. This product is intended for use in research and analytical applications. Lactobionic acid is a bionic acid that can be naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties. Lactobionic acid can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs .

HY-P991394

SEA-TGT	Transmembrane Glycoprotein	Cancer
SEA-TGT is a human monoclonal antibody (mAb) targeting TIGIT. SEA-TGT enhances binding to the activating FcγRIIIA while reducing binding to the inhibitory FcγRIIb. SEA-TGT can be used in advanced solid tumors and Lymphoma research .

HY-RS17528

sea Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
sea Mouse Pre-designed siRNA Set A contains three designed siRNAs for sea gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

sea Mouse Pre-designed siRNA Set A sea Mouse Pre-designed siRNA Set A

HY-RS12601

SEA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SEA Human Pre-designed siRNA Set A contains three designed siRNAs for SEA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SEA Human Pre-designed siRNA Set A SEA Human Pre-designed siRNA Set A

HY-N12705A

Thermohexamine hydrochloride	Others	Others
Thermohexamine hydrochloride is a polyamine that can be isolated from sea urchin .

HY-P10431

Hc-CATH SEA snake cathelicidin	Bacterial	Infection Inflammation/Immunology
Hc-CATH (Sea snake cathelicidin) is an antibacterial peptide with broad-spectrum. Hc-CATH inhibits Shigella dysenteriae and Klebsiella pneumoniae with MIC of 0.16 mM-20.67 mM. Hc-CATH exhibits anti-inflammatory efficacy .

HY-N8195

Quercetin 3-O-sophoroside-7-O-rhamnoside	Others	Others
Quercetin 3-O-sophoroside-7-O-rhamnoside is a flavonoid found in sea buckthorn berries .

HY-P10595

Antho-Rwamide II	Sodium Channel	Neurological Disease
Antho-Rwamide II is a neuropeptide that can be isolated from the sea anemone Anthopleura elegantissima. Antho-Rwamide II can induce contraction of the endothelial muscles of the sea anemone and participate in neurotransmission. Antho-Rwamide II can be used to explore the function of the nervous system in invertebrates .

HY-P4898

Anthopleurin-A	Sodium Channel	Cardiovascular Disease
Anthopleurin-A is a soidum channel toxin. Anthopleurin-A is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A can be isolated from the sea anemone .

HY-115431

Antho-rwamide I	Aminopeptidase	Neurological Disease
Antho-rwamide I is a neuropeptide that can be isolated from the sea anemone Anthopleura elegantissima. Antho-rwamide I is resistant to nonspecific aminopeptidases, which increases the stability of the peptide after neuronal release .

HY-P4898A

Anthopleurin-A TFA	Sodium Channel	Cardiovascular Disease
Anthopleurin-A TFA is a soidum channel toxin. Anthopleurin-A TFA is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A TFA can be isolated from the sea anemone .

HY-114899S

Azamethiphos-d6	Isotope-Labeled Compounds Cholinesterase (ChE) Insecticide	Neurological Disease
Azamethiphos-d₆ is deuterated labeled Azamethiphos (HY-114899). Azamethiphos is an organophosphate insecticide that inhibits AChE. Azamethiphos inhibits sea lice .

HY-114899R

Azamethiphos (Standard)	Reference Standards Cholinesterase (ChE) Insecticide	Neurological Disease
Azamethiphos (Standard) is the analytical standard of Azamethiphos (HY-114899). This product is intended for research and analytical applications. Azamethiphos is an organophosphate insecticide that inhibits AChE. Azamethiphos inhibits sea lice .

HY-P10549

NGFFFamide	Endogenous Metabolite	Neurological Disease
NGFFFamide is a muscle-active neuropeptide found in sea urchins. NGFFFamide regulates muscle activity by directly interacting with receptor proteins on muscle cells, or indirectly by stimulating nerves or other cell types to release muscle-active factors. NGFFFamide can be used to study muscle contraction and relaxation .

HY-124550

Sarcophine (+)-Sarcophine	Endogenous Metabolite	Neurological Disease
Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC₅₀ value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum .

HY-119332

3-Keto petromyzonol	Endogenous Metabolite	Endocrinology
3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey .

HY-N15051

Harveynone	Others	Others
Harveynone can inhibit the formation of Sea urchin eggs Spindle .

HY-RS08730

MST1R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MST1R Human Pre-designed siRNA Set A contains three designed siRNAs for MST1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MST1R Human Pre-designed siRNA Set A MST1R Human Pre-designed siRNA Set A

HY-N7747

Sceptrin dihydrochloride	Others	Infection
Sceptrin dihydrochloride is a compound isolated from the sea sponge Agelas sceptrum that is an antimicrobial agent .

HY-N13989

Acetophthalidin	Others	Cancer
Acetophthalidin is an inhibitor of mammalian cell cycle found in a fungus isolated from a sea sediment .

HY-N7237

Stichloroside B1	Fungal	Infection
Stichloroside B1 is a class of antifungal triterpenoid oligosaccharide isolated from the sea cucumber Stichopus chloronotus (BRANDT) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1207

Urethane 4 Publications Verification Ethyl carbamate; Carbamic acid ethyl ester; Ethylurethane	Infection Structural Classification Natural Products Microorganisms Neurological Disease Classification of Application Fields Disease Research Fields Source Classification	Environmental Pollutants Bacterial Parasite
Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro .

HY-16929

Latrunculin A 10+ Cited Publications LAT-A	Macrolide Antibiotics Animals Classification of Application Fields Antibiotics Marine natural products Other Diseases Sponge Disease Research Anticancer Disease Research Fields Source Classification	Arp2/3 Complex
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-N7059

Lactobionic acid	Infection Microorganisms Classification of Application Fields Disease Research Fields Saccharides Source Classification	Bacterial Reactive Oxygen Species (ROS)
Lactobionic acid is a bionic acid that can be naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties. Lactobionic acid can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .

HY-127170

3-Hydroxycoumarin	Structural Classification other families Classification of Application Fields Other Diseases Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	Lipoxygenase Tyrosinase
3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase with an IC₅₀ for recombinant human tyrosinase (rHT) of 26 μM, and a K_i of 3.39 μM; its IC₅₀ for LOX is 9.5 μM. 3-Hydroxycoumarin has DPPH free radical scavenging activity (IC₅₀ = 31.2 μM). 3-Hydroxycoumarin has photoprotective effects on sea urchin zygotes and embryos .

HY-P1346

APETx2	Natural Products Animals Source Classification	Sodium Channel
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

HY-123063

Petromyzonol 5α-Petromyzonol; 5α-PZ	Structural Classification Marine natural products Marine microorganism Steroids Source Classification	Others
Petromyzonol (5α-Petromyzonol) is a tetrahydroxy stearol produced by the bile of sea lamprey larvae from the bile acid precursor acetylcholic acid. Petromyzonol sulfate acts as a pheromone and oviposition chemical attractant .

HY-B1207R

Urethane (Standard) Ethyl carbamate (Standard); Carbamic acid ethyl ester (Standard); Ethylurethane (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Bacterial Parasite
Urethane (Standard) is the analytical standard of Urethane. This product is intended for research and analytical applications. Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro .

HY-127170R

3-Hydroxycoumarin (Standard)	Structural Classification other families Coumarins Phenylpropanoids Plants Source Classification	Lipoxygenase Reference Standards
3-Hydroxycoumarin (Standard) is the analytical standard of 3-Hydroxycoumarin. This product is intended for research and analytical applications. 3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage .

HY-N2225

Isorhamnetin-3-O-sophoroside-7-O-rhamnoside	Infection Flavonols Flavonoids Classification of Application Fields Elaeagnaceae Hippophaë rhamnoides Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
Isorhamnetin-3-O-sophoroside-7-O-rhamnoside, the major flavonol glycoside, is isolated from sea buckthorn (Hippopha rhamnoides). Isorhamnetin-3-O-sophoroside-7-O-rhamnoside has the algicidal activity against the growth of the harmful microalgae .

HY-41314

Ethyl 3-methyl-2-butenoate	Natural Products Elaeagnaceae Hippophaë rhamnoides Plants Source Classification	Endogenous Metabolite
Ethyl 3-methyl-2-butenoate is a volatile compound that can be isolated from sea buckthorn .

HY-N7059R

Lactobionic acid (Standard)	Structural Classification Microorganisms Saccharides Source Classification	Reference Standards Bacterial Reactive Oxygen Species (ROS)
Lactobionic acid (Standard) is an analytical standard for lactobionic acid. This product is intended for use in research and analytical applications. Lactobionic acid is a bionic acid that can be naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties. Lactobionic acid can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .

HY-N12705A

Thermohexamine hydrochloride	Natural Products Animals Source Classification	Others
Thermohexamine hydrochloride is a polyamine that can be isolated from sea urchin .

HY-N8195

Quercetin 3-O-sophoroside-7-O-rhamnoside	Flavonols Flavonoids Classification of Application Fields Elaeagnaceae Hippophaë rhamnoides Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
Quercetin 3-O-sophoroside-7-O-rhamnoside is a flavonoid found in sea buckthorn berries .

HY-124550

Sarcophine (+)-Sarcophine	Natural Products Neurological Disease Classification of Application Fields Animals Marine natural products Other marine organisms Disease Research Fields Source Classification	Endogenous Metabolite
Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC₅₀ value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum .

HY-119332

3-Keto petromyzonol	Animals Classification of Application Fields Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite
3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey .

HY-N15051

Harveynone	Natural Products Microorganisms Source Classification	Others
Harveynone can inhibit the formation of Sea urchin eggs Spindle .

HY-N7747

Sceptrin dihydrochloride	Natural Products Marine natural products Sponge Source Classification	Others
Sceptrin dihydrochloride is a compound isolated from the sea sponge Agelas sceptrum that is an antimicrobial agent .

HY-N13989

Acetophthalidin	Natural Products Microorganisms Source Classification	Others
Acetophthalidin is an inhibitor of mammalian cell cycle found in a fungus isolated from a sea sediment .

HY-N7237

Stichloroside B1	Triterpenes Structural Classification Tetracyclic Triterpenoids Animals Terpenoids Source Classification	Fungal
Stichloroside B1 is a class of antifungal triterpenoid oligosaccharide isolated from the sea cucumber Stichopus chloronotus (BRANDT) .

HY-130072

Bivittoside B	Triterpenes Structural Classification Tetracyclic Triterpenoids Animals Terpenoids Source Classification	Fungal
Bivittoside B is a non-sulfated hexoside analog derived from Bovine sea cucumber, exhibiting antifungal and potential antitumor activities.

HY-N3162

Obtucarbamate B	Natural Products Animals Source Classification	Others
Obtucarbamate B is a carbamate derivative, that can be isolated from the South China Sea gorgonian coral Melitodes squamata Nutting .

HY-N12389

Quellenin	Monophenols Microorganisms Phenols Source Classification	Fungal
Quellenin is an anti-saprolegnia compound. Quellenin can be isolated from deep-sea fungus Aspergillus sp. YK-76

HY-N15514

Harzianol N	Microorganisms Terpenoids Diterpenoids Source Classification	Others
Harzianol N is a harziane-type diterpene derivative isolated from the deep-sea sediment-derived fungus Trichoderma sp. SCSIOW21 .

HY-N10262

Piliformic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Endogenous Metabolite
Piliformic acid is a fungal metabolite found in the endophytic fungus Xylariasp sp.(No. 2508) from mangrove trees from the coast of the South China Sea .

HY-127042

6,7-Epoxy-latrunculin A 6,7-Epoxy-LAT-A	Natural Products Microorganisms Source Classification	Arp2/3 Complex
6,7-Epoxy-latrunculin A can be isolated from the Red Sea sponge Negombata magnifica and is initially identified as an inhibitor of actin polymerization by its morphological effects .

HY-N16053

Antibacterial agent 288	Monophenols Marine natural products Phenols Marine microorganism Source Classification	Bacterial Fungal
Antibacterial agent 288 (Compound 1) has antibacterial and antifungal activities. Antibacterial agent 288 can be isolated from Mangrove fungus (No. B60) from the South China Sea .

HY-N15509

Harzianol K	Microorganisms Terpenoids Diterpenoids Source Classification	NO Synthase
Harzianol K is a novel harziane - type diterpene derivative discovered from the deep - sea sediment fungus Trichoderma sp. SCSIOW21. It has an inhibitory effect on NO production and can be used in the research of the anti - inflammatory field .

HY-W750691

Citranaxanthin	Natural Products Marine natural products Other marine organisms Source Classification	Drug Derivative
Citranaxanthin is a carotenoid that can be isolated from Sea Hare Dolabella auriculari. Carotenoids are important biological active, and may regulate cellular differentiation, growth control, photooxidative protection, cell membrane stability, photosynthesis, vision process and nutrition .

HY-W065835

2-Bromoaldisine	Alkaloids Pyrrole Alkaloids Marine natural products Source Classification	HIV
2-Bromoaldisine is a pyrrole alkaloid that can be isolated from the Red Sea: marine sponge Stylissa carter. 2-Bromoaldisine inhibits HIV-1 vector infection. 2-Bromoaldisine inhibits Raf/MEK/MAPK pathway .

HY-N7821

Aphidicolin 17-acetate Aphidicolin 17-monoacetate	Structural Classification Natural Products Microorganisms Source Classification	DNA/RNA Synthesis
Aphidicolin 17-acetate is a selective eukaryotic DNA polymerase α inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses .

HY-137566

Cucumarioside H	Triterpenes Animals Terpenoids Source Classification	Mitochondrial Metabolism
Cucumarioside H is a novel triterpene glycoside isolated from the Far Eastern sea cucumber Eupentacta fraudatrix, including H2, H3 and H4. These glycosides have a branched pentasyl structure with a rare 3-O-methyl-D-xylose as the terminal monosaccharide. H2 contains 23,24,25,26,27-pentanolone sterols and has an 18(16)-lactone, which is not common in sea cucumbers. The glycoside portion of H3 contains an extremely rare ethoxyl radical at the 25 position, which may be an artifact formed during the long ethanol extraction process. Studies have shown that H1-3 are cytotoxic to mouse spleen lymphocytes, hemolytic to mouse erythrocytes, and cytotoxic to Ehrlich carcinoma cells. The presence of a 25-hydroxyl group in the glycoside portion significantly reduces these activities.

HY-N15505

Cycloneroside D	Microorganisms Terpenoids Sesquiterpenes Source Classification	NO Synthase
Cycloneroside D is a novel sesquiterpene aminoglycoside compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Cycloneroside D has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC₅₀ value for inhibiting the production of NO is 42.0 μM. Cycloneroside D can be used in the research of the anti - inflammatory field .

HY-N15510

Harzianol J	Microorganisms Terpenoids Diterpenoids Source Classification	NO Synthase
Harzianol J is a harziane - type diterpene compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Harzianol J has certain anti - inflammatory activity. At a concentration of 100 µM, its inhibition rate of NO is 81.8%, and its IC₅₀ value for inhibiting the production of NO is 66.7 µM. Harzianol J can be used in the research of the anti - inflammatory field .

HY-N10177

Peniterphenyl A	Infection Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification	HSV
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits HSV-1/2 virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-N7236

Pervicoside B	Triterpenes Animals Terpenoids Source Classification	Parasite Fungal
Pervicoside B is a glycoside C isolated from Neothyone gibbosa sea cucumber. In vitro studies have shown that Pervicoside B has a potent antiparasitic effect against Leishmania mexicana, inhibiting 100% of promastigotes at 5-10 μg/mL. Pervicoside B also exhibits strong antifungal activity against Aspergillus niger, with MIC values ranging from 4.65 to 16.7 μg/mL. Pervicoside B has potential applications in the inhibition of parasitic infections and fungal diseases .

HY-115407

Cochliodone A	Natural Products Microorganisms Source Classification	Bacterial
Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC₅₀s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2) .

HY-N18756

Sea-buckthorn extract	Structural Classification Extract	Others
Sea-buckthorn extract is derived from the fruit of Hippophae rhamnoides Linn. The main active ingredient is Seabuckthorn Favone.

HY-129562

Cucumechinoside D	Other Terpenoids Animals Terpenoids Source Classification	Others
Cucumechinoside D is a potent bioactive compound, which is found in the sea cucumber Cucumaria echinata .

HY-130047

Bivittoside A	Triterpenes Structural Classification Tetracyclic Triterpenoids Animals Terpenoids Source Classification	Fungal
Bivittoside A is a non-sulfated hexoside analog derived from Bovine sea cucumber, exhibiting antifungal properties and potential for antitumor applications.

HY-W750726

7,8,7’,8’-Tetradehydroastaxanthin	Natural Products Animals Source Classification	Endogenous Metabolite
7,8,7’,8’-Tetradehydroastaxanthin is a glycopeptide isolated from the carotenoid protein of red sea star (Asterias rubens) .

HY-N15515

Harzianol O	Microorganisms Terpenoids Diterpenoids Source Classification	Others
Harzianol O is a harziane-type diterpene derivative isolated from the deep-sea sediment-derived fungus Trichoderma sp. SCSIOW21 .

HY-W714898

2-Hexadecanol	Structural Classification Natural Products Duchesnea indica (Andr.) Focke Rosaceae Plants Source Classification	Apoptosis Caspase
2-Hexadecanol is a fatty acid based compound. 2-Hexadecanol can be isolated from marine organism Sea pen. 2-Hexadecanol induces Apoptosis, elevates the expression of caspase-3 and caspase-8. 2-Hexadecanol exhibits anticancer activity against breast cancer and cervical cancer .

HY-N15504

Cycloneroside C	Microorganisms Terpenoids Sesquiterpenes Source Classification	NO Synthase
Cycloneroside C is a novel sesquiterpene aminoglycoside compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Cycloneroside C has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC₅₀ value for inhibiting the production of NO is 57.1 μM. Cycloneroside C can be used in the research of the anti - inflammatory field .

HY-126563

Phyllospadine	Structural Classification Alkaloids Phyllospadix iwatensis Makino other families Other Alkaloids Plants Source Classification	Drug Derivative
Phyllospadine (Compound I) is a flavonoidal alkaloid found in the sea-grass Phyllospadix iwatensis. Flavonoids constitute a class of plant secondary metabolites characterized by a polyphenolic structure; they possess antioxidant, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties, as well as the capacity to modulate the functions of key cellular enzymes, finding application in the treatment of diseases such as cancer, Alzheimer's disease, and atherosclerosis .

HY-N17442

Echinoside A	Triterpenes Structural Classification Polysaccharides Animals Terpenoids Saccharides Source Classification	Topoisomerase Caspase PARP Fungal DNA/RNA Synthesis
Echinoside A is a saponin. Echinoside A can be isolated from sea cucumber. Echinoside A inhibits the catalytic activity of Top2α, reduces the noncovalent binding of Top2α to DNA. Echinoside A activates Caspase-3 and induces PARP cleavage. Echinoside A induces Apoptosis. Echinoside A has anticancer activity against prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Echinoside A exhibits antifungal activity against a variety of fungi, with a minimum growth inhibitory concentration range of 3.12 to 50.0 μg/mL, including potent activity against Aspergillus and Penicillium species .

Cat. No.	Product Name	Chemical Structure