2-Bromoaldisine
Based on 1 Customer Validation
2-Bromoaldisine is a pyrrole alkaloid that can be isolated from the Red Sea: marine sponge Stylissa carter. 2-Bromoaldisine inhibits HIV-1 vector infection. 2-Bromoaldisine inhibits Raf/MEK/MAPK pathway.
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- CAS No.: 96562-96-8
- 화학식: C8H7BrN2O2
- 분자량:243.06
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
>10000 nM
Compound: 2
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Inhibition of human adenocarcinoma cell line Caco-2 proliferation
Inhibition of human adenocarcinoma cell line Caco-2 proliferation
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[PMID: 11784156] |
| LoVo | IC50 |
>10000 nM
Compound: 2
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Inhibition of human adenocarcinoma cell line LoVo proliferation
Inhibition of human adenocarcinoma cell line LoVo proliferation
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[PMID: 11784156] |
Chemical Information
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CAS No. 96562-96-8
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Appearance Solid
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분자량 243.06
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화학식 C8H7BrN2O2
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Color White to off-white
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SMILES
C1CNC(=O)C2=C(C1=O)C=C(N2)Br
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Structure Classification
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Initial Source
marine sponge Stylissa carteri
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
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Data Sheet (270 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Bromoaldisine Related Classifications
HY-W065835 Related Classifications
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