Lamprey LH-RH I

Cat. No.: HY-P3673: FAQs
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Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models.

For research use only. We do not sell to patients.

Lamprey LH-RH I Chemical Structure

CAS No. : 102634-23-1

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Description

Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models^[1].

In Vitro

Lamprey LH-RH I has a primary mechanism of transport to the pituitary is simple diffusion from neuronal terminals in the neurohypophysis to the adenohypophysis. An additional route is via secretion into the third ventricle and transport by tanycytes to the adenohypophysis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lamprey LH-RH I (5-200 μg/kg; i.p.; single dose or twice) elevates plasma steroid levels and stimulates lamprey ovulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female sea-run sea lampreys^[1]
Dosage:	5 μg/kg, 50 μg/kg, 100 μg/kg, 200 μg/kg; dissolved in 0.6% NaCl in distilled water
Administration:	Intraperitoneal injection; single dose or twice; observed for 30 days
Result:	Significantly increased estradiol in a dose-related manner. Resulted 80% of the lampreys ovulation at 200 or 100 μg/kg compared in a doserelated manner.

Molecular Weight

1226.34

Formula

C₅₈H₇₉N₁₅O₁₅

CAS No.

102634-23-1

Sequence Shortening

{Glp}-HYSLEWKPG-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sower SA, et al. Comparative biological properties of lamprey gonadotropin-releasing hormone in vertebrates. Endocrinology. 1987 Feb;120(2):773-9. [Content Brief]

[2]. King JC, et al. Neuronal systems immunoreactive with antiserum to lamprey gonadotropin-releasing hormone in the brain of Petromyzon marinus. Cell Tissue Res. 1988 Jul;253(1):1-8. [Content Brief]

Lamprey LH-RH I Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lamprey LH-RH I102634-23-1GnRH ReceptorGonadotropin releasing hormone receptorGNRHRlampreysea-run sea lampreyplasma steroidovulationInhibitorinhibitorinhibit

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