Capsaicin (Synonyms: (E)-Capsaicin)

Name: Capsaicin
Brand: MedChemExpress
SKU: HY-10448
Rating: 5.0 (78 reviews)

Cat. No.: HY-10448 Purity: 99.99%: Data Sheet
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Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects.

For research use only. We do not sell to patients.

CAS No. : 404-86-4

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10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
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Based on 78 publication(s) in Google Scholar

Other Forms of Capsaicin:

78 Publications Citing Use of MCE Capsaicin

In Vivo Efficacy Study

Bio/Physico-chemical Assay

Cell Imaging/Staining

IHC

Cell Proliferation/Viability Assay

: Capsaicin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102. [Abstract]; Capsaicin (1-100 μM) dose‐response curves in HEK293T cells expressing CcIav/CcNan (EC50 indicated; empty vector control).

: Capsaicin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102. [Abstract]; Capsaicin (100 μM, 10 min) activation of p‐CcAKHR in HEK293T cells co‐expressing CcIav/CcNan, CcPKCα, and CcAKHR.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102. [Abstract]; Ca²⁺ imaging (Fluo‐4, green) in HEK293T cells expressing CcIav, CcNan, or both to capsaicin (100 μM) treatments (mCherry vector control). The negative control involved HEK293T cells expressing an empty plasmid (pcDNA3.1(+)‐mCherry) treated with capsaicin.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Jun;45(6):1160-1174. [Abstract]; An acute pain mouse model was established by injecting Capsaicin (0.01%, 20 µL in 10% DMSO/saline) into the lower left or right hind leg of mice. Following injection of nicotine into the substantia nigra (SNr) of the right hemisphere in Cap mice, both the partial thromboplasty (PWT) and partial thromboplasty (PWL) of the bilateral hind paws increased.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Apr 17;14(1):2182. [Abstract]; VPChAT-BLA-projected light inhibits Capsaicin (0.01%, 20 µl in 10% DMSO/saline)-induced acute inflammatory pain in mice with PWT.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]; Capsaicin (10 and 15mg/kg, i.p.,once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. Representative images of MTS (blue color), Picrosirius Red staining (red color), and IF staining of fibronectin (red color) and COL1A1 (green color) for kidney sections from adenine-fed (Adenine) or normal-fed (Ctrl) mice. Scale bars are 50 μm.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]; Capsaicin (10 and 15 mg/kg, i.p., once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. WB images of fibronectin and COL1A1 expressions in kidney lysates from mice.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]; Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved survival rate of Adenine (0.25% w/w)-fed mice. (A) Relative weight curves of indicated mice as described in A (n = 6). Mouse weight is measured once per 3 days, the initial weight is set to 1, and day 0 means the time point starting Adenine-rich diet. (B) Kaplan-Meier survival analysis of indicated mice as described in A (n = 12). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]; Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved survival rate and kidney function of Adenine (0.25% w/w)-fed mice. Concentrations of serum creatinine, urea, and albumin from mice (n = 8). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]; Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) treatment prevented phenotypic alteration of tubular epithelial cells in the kidneys from Adenine (ADE) (0.25% w/w)-fed mice. Representative IHC staining images of E-cadherin and vimentin kidney sections from mice. Scale bars are 25 μm.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jun 24;10(17):7906-7920. [Abstract]; The expression of cell cycle-associated molecules is altered by Capsaicin treatment in both cell lines.The cell-cycle inhibitor p27Kip1 is upregulated after Capsaicin treatment while the G1-S phase transition marker cyclin D1 is downregulated. p38 phosphorylation levels are also decreased following capsaicin treatment.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jun 24;10(17):7906-7920. [Abstract]; CNE2 and SUNE1 cell growth is inhibited by Capsaicin in a dose-dependent manner.

: Capsaicin purchased from MedChemExpress. Usage Cited in: Clin Exp Pharmacol Physiol. 2017 Jul;44(7):803-814. [Abstract]; Western blot analysis showing that the CAP (0.5 mg/kg) injection inhibits the increase of p65 expression and phosphorylation at 24 h after I/R injury.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

EC50: 290 nM (hTRPV1, in HEK293 cell)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A2058	IC₅₀	> 100 3 Compound: Capsaicin	Cytotoxicity against human A2058 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human A2058 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
A2058	IC₅₀	>100 3 Compound: Capsaicin	Cytotoxicity against human A2058 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human A2058 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
A2058	IC₅₀	> 100 3 Compound: Capsaicin	Cytotoxicity against human A2058 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human A2058 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
B16-F10	IC₅₀	> 100 3 Compound: Capsaicin	Cytotoxicity against mouse B16F10 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse B16F10 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
B16-F10	IC₅₀	117 3 Compound: 1	Antiproliferative activity against B16-F10 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Antiproliferative activity against B16-F10 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 37000154]
B16-F10	IC₅₀	>100 3 Compound: Capsaicin	Cytotoxicity against mouse B16F10 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse B16F10 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
B16-F10	IC₅₀	117 3 Compound: 1	Antiproliferative activity against B16-F10 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Antiproliferative activity against B16-F10 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 37000154]
BGC-823	IC₅₀	4.659 3 Compound: 1	Antiproliferative activity against human BGC-823 cells assessed as reduction in cell viability incubated for 5 days by MTS assay Antiproliferative activity against human BGC-823 cells assessed as reduction in cell viability incubated for 5 days by MTS assay	[PMID: 33581557]
BGC-823	IC₅₀	4.659 3 Compound: 1	Antiproliferative activity against human BGC-823 cells assessed as reduction in cell viability incubated for 5 days by MTS assay Antiproliferative activity against human BGC-823 cells assessed as reduction in cell viability incubated for 5 days by MTS assay	[PMID: 33581557]
B16-F10	IC₅₀	> 100 3 Compound: Capsaicin	Cytotoxicity against mouse B16F10 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse B16F10 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
CHO	EC₅₀	25.9 1 Compound: 1; CAP	Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method	[PMID: 31702924]
HBMEC-2	EC₅₀	16.37 3 Compound: Capsaicin	Neuroprotective activity against H2O2-induced cell damage in human HBMEC2 cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced cell damage in human HBMEC2 cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay	[PMID: 31541868]
BGC-823	IC₅₀	4.659 3 Compound: 1	Antiproliferative activity against human BGC-823 cells assessed as reduction in cell viability incubated for 5 days by MTS assay Antiproliferative activity against human BGC-823 cells assessed as reduction in cell viability incubated for 5 days by MTS assay	[PMID: 33581557]
CHO	EC₅₀	44.8 1 Compound: 1; CAP	Agonist activity at rat TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method Agonist activity at rat TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method	[PMID: 31702924]
HCT-116	IC₅₀	40.16 3 Compound: Capsaicin	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay	[PMID: 34795858]
CHO	EC₅₀	44.8 1 Compound: Capsaicin	In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells	[PMID: 12825950]
HEK293	EC₅₀	0.0053 3 Compound: 1a	Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as Ca2+ influx by Fluo-4 dye based assay Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as Ca2+ influx by Fluo-4 dye based assay	[PMID: 25666822]
CHO	EC₅₀	25.9 1 Compound: 1; CAP	Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method	[PMID: 31702924]
HBMEC-2	EC₅₀	16.37 3 Compound: Capsaicin	Neuroprotective activity against H2O2-induced cell damage in human HBMEC2 cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced cell damage in human HBMEC2 cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay	[PMID: 31541868]
CHO	EC₅₀	44.8 1 Compound: 1; CAP	Agonist activity at rat TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method Agonist activity at rat TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method	[PMID: 31702924]
HEK293	EC₅₀	0.02 3 Compound: capsaicin	Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level	[PMID: 19361197]
HCT-116	IC₅₀	40.16 3 Compound: Capsaicin	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay	[PMID: 34795858]
CHO	EC₅₀	44.8 1 Compound: Capsaicin	In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells	[PMID: 12825950]
HEK293	EC₅₀	0.0039 3 Compound: Capsaicin	Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry	[PMID: 22257892]
HEK293	EC₅₀	0.0039 3 Compound: Capsaicin	Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry	[PMID: 22257892]
CHO	EC₅₀	44.8 1 Compound: Capsaicin	Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium uptake Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium uptake	[PMID: 19135377]
HEK293	IC₅₀	0.008 3 Compound: 1a	Antagonist activity against human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx pre-treated 5 mins before capsaicin addition by Fluo-4 dye based assay Antagonist activity against human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx pre-treated 5 mins before capsaicin addition by Fluo-4 dye based assay	[PMID: 25666822]
HEK293	EC₅₀	0.0053 3 Compound: 1a	Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as Ca2+ influx by Fluo-4 dye based assay Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as Ca2+ influx by Fluo-4 dye based assay	[PMID: 25666822]
HeLa	IC₅₀	>50 3 Compound: CAP	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29685681]
HEK293	IC₅₀	0.008 3 Compound: 1a	Antagonist activity against human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx pre-treated 5 mins before capsaicin addition by Fluo-4 dye based assay Antagonist activity against human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx pre-treated 5 mins before capsaicin addition by Fluo-4 dye based assay	[PMID: 25666822]
CHO	EC₅₀	25.9 1 Compound: 1; CAP	Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method	[PMID: 31702924]
HeLa	IC₅₀	> 50 3 Compound: CAP	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29685681]
Jurkat	IC₅₀	~ 128 3 Compound: 1	Induction of apoptosis in human Jurkat cells assessed as increase in apoptotic cells by propidium iodide staining based flow cytometry Induction of apoptosis in human Jurkat cells assessed as increase in apoptotic cells by propidium iodide staining based flow cytometry	[PMID: 37000154]
K562	IC₅₀	49.41 3 Compound: CAP	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 29685681]
K562	IC₅₀	49.41 3 Compound: CAP	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 29685681]
MCF7	IC₅₀	100 3 Compound: Capsaicin	Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay	[PMID: 33508189]
HEK293	EC₅₀	40 1 Compound: capsaicin	Agonist activity at human recombinant TRPV1 expressed in human HEK293 cells Agonist activity at human recombinant TRPV1 expressed in human HEK293 cells	[PMID: 17046253]
MCF7	IC₅₀	49.97 3 Compound: CAP	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 29685681]
MDA-MB-231	IC₅₀	120 3 Compound: 24	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by MTT assay	[PMID: 32686940]
HEK293	EC₅₀	40 1 Compound: 1a	Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level	[PMID: 19951840]
HBMEC-2	EC₅₀	16.37 3 Compound: Capsaicin	Neuroprotective activity against H2O2-induced cell damage in human HBMEC2 cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced cell damage in human HBMEC2 cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay	[PMID: 31541868]
CHO	EC₅₀	44.8 1 Compound: 1; CAP	Agonist activity at rat TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method Agonist activity at rat TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method	[PMID: 31702924]
NCI-H460	IC₅₀	30.66 3 Compound: Capsaicin	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay	[PMID: 34795858]
CHO	EC₅₀	44.8 1 Compound: Capsaicin	Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium uptake Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium uptake	[PMID: 19135377]
HCT-116	IC₅₀	40.16 3 Compound: Capsaicin	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay	[PMID: 34795858]
SH-SY5Y	EC₅₀	14.02 3 Compound: Capsaicin	Neuroprotective activity against H2O2-induced cell damage in human SH-SY5Y cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced cell damage in human SH-SY5Y cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay	[PMID: 31541868]
CHO	EC₅₀	44.8 1 Compound: Capsaicin	In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells	[PMID: 12825950]
SH-SY5Y	EC₅₀	2.32 3 Compound: Capsaicin	Agonist activity at rat TRPV1 expressed in human SH-SY5Y cells assessed as intracellular calcium accumulation by Fluo-4 NW dye based fluorescence assay Agonist activity at rat TRPV1 expressed in human SH-SY5Y cells assessed as intracellular calcium accumulation by Fluo-4 NW dye based fluorescence assay	[PMID: 30783490]
MCF7	IC₅₀	49.97 3 Compound: CAP	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 29685681]
HEK293	EC₅₀	0.0039 3 Compound: Capsaicin	Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry	[PMID: 22257892]
SK-MEL-25	IC₅₀	> 100 3 Compound: Capsaicin	Cytotoxicity against human SK-MEL-25 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human SK-MEL-25 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
MCF7	IC₅₀	~ 53 3 Compound: 1	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 37000154]
HEK293	EC₅₀	0.0053 3 Compound: 1a	Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as Ca2+ influx by Fluo-4 dye based assay Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as Ca2+ influx by Fluo-4 dye based assay	[PMID: 25666822]
SK-OV-3	IC₅₀	22.03 3 Compound: Capsaicin	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay	[PMID: 34795858]
MCF7	IC₅₀	100 3 Compound: Capsaicin	Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay	[PMID: 33508189]
HEK293	EC₅₀	0.02 3 Compound: capsaicin	Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level	[PMID: 19361197]
T47D	IC₅₀	100 3 Compound: Capsaicin	Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay	[PMID: 33508189]
MDA-MB-231	IC₅₀	120 3 Compound: 24	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by MTT assay	[PMID: 32686940]
HEK293	EC₅₀	40 1 Compound: 1a	Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level	[PMID: 19951840]
U-87MG ATCC	IC₅₀	> 100 3 Compound: Capsaicin	Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
HEK293	EC₅₀	40 1 Compound: capsaicin	Agonist activity at human recombinant TRPV1 expressed in human HEK293 cells Agonist activity at human recombinant TRPV1 expressed in human HEK293 cells	[PMID: 17046253]
NCI-H1299	IC₅₀	>= 200 3 Compound: 1	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 37000154]
NCI-H460	IC₅₀	30.66 3 Compound: Capsaicin	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay	[PMID: 34795858]
SH-SY5Y	EC₅₀	2.32 3 Compound: Capsaicin	Agonist activity at rat TRPV1 expressed in human SH-SY5Y cells assessed as intracellular calcium accumulation by Fluo-4 NW dye based fluorescence assay Agonist activity at rat TRPV1 expressed in human SH-SY5Y cells assessed as intracellular calcium accumulation by Fluo-4 NW dye based fluorescence assay	[PMID: 30783490]
SH-SY5Y	EC₅₀	14.02 3 Compound: Capsaicin	Neuroprotective activity against H2O2-induced cell damage in human SH-SY5Y cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced cell damage in human SH-SY5Y cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay	[PMID: 31541868]
SK-MEL-25	IC₅₀	>100 3 Compound: Capsaicin	Cytotoxicity against human SK-MEL-25 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human SK-MEL-25 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
HEK293	IC₅₀	0.008 3 Compound: 1a	Antagonist activity against human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx pre-treated 5 mins before capsaicin addition by Fluo-4 dye based assay Antagonist activity against human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx pre-treated 5 mins before capsaicin addition by Fluo-4 dye based assay	[PMID: 25666822]
SK-OV-3	IC₅₀	22.03 3 Compound: Capsaicin	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay	[PMID: 34795858]
T47D	IC₅₀	100 3 Compound: Capsaicin	Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay	[PMID: 33508189]
U-87MG ATCC	IC₅₀	>100 3 Compound: Capsaicin	Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
HeLa	IC₅₀	> 50 3 Compound: CAP	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29685681]
Jurkat	IC₅₀	~ 128 3 Compound: 1	Induction of apoptosis in human Jurkat cells assessed as increase in apoptotic cells by propidium iodide staining based flow cytometry Induction of apoptosis in human Jurkat cells assessed as increase in apoptotic cells by propidium iodide staining based flow cytometry	[PMID: 37000154]
K562	IC₅₀	49.41 3 Compound: CAP	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 29685681]
MCF7	IC₅₀	100 3 Compound: Capsaicin	Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay	[PMID: 33508189]
MCF7	IC₅₀	49.97 3 Compound: CAP	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 29685681]
MCF7	IC₅₀	~ 53 3 Compound: 1	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 37000154]
MDA-MB-231	IC₅₀	120 3 Compound: 24	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by MTT assay	[PMID: 32686940]
NCI-H1299	IC₅₀	>= 200 3 Compound: 1	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 37000154]
NCI-H460	IC₅₀	30.66 3 Compound: Capsaicin	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay	[PMID: 34795858]
SH-SY5Y	EC₅₀	14.02 3 Compound: Capsaicin	Neuroprotective activity against H2O2-induced cell damage in human SH-SY5Y cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced cell damage in human SH-SY5Y cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay	[PMID: 31541868]
SH-SY5Y	EC₅₀	2.32 3 Compound: Capsaicin	Agonist activity at rat TRPV1 expressed in human SH-SY5Y cells assessed as intracellular calcium accumulation by Fluo-4 NW dye based fluorescence assay Agonist activity at rat TRPV1 expressed in human SH-SY5Y cells assessed as intracellular calcium accumulation by Fluo-4 NW dye based fluorescence assay	[PMID: 30783490]
SK-MEL-25	IC₅₀	> 100 3 Compound: Capsaicin	Cytotoxicity against human SK-MEL-25 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human SK-MEL-25 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]
SK-OV-3	IC₅₀	22.03 3 Compound: Capsaicin	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based assay	[PMID: 34795858]
T47D	IC₅₀	100 3 Compound: Capsaicin	Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay	[PMID: 33508189]
U-87MG ATCC	IC₅₀	> 100 3 Compound: Capsaicin	Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 24 hrs by MTT assay	[PMID: 31104785]

In Vitro

Capsaicin (50-300 μM; 24-72 hours) shows an augmented decrease in cell growth in a dose- and time-dependent manner. The observed IC₅₀ value is around 150 μM^[2].
Capsaicin (50-300 μM; 24-72 hours) shows increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels, and decreases anti-apoptotic Bcl-2 protein and increases pro-apoptotic Bad/Bax expression^[2].
Capsaicin increases the nuclear condensation, nuclear DNA fragmentation and sub-G1 DNA content^[2].
Capsaicin suppresses the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Human pharyngeal squamous carcinoma cells (FaDu) cells
Concentration:	50 µM, 100 µM, 200 µM, and 300 µM
Incubation Time:	24 hours, 48 hours and 72 hours
Result:	Showed an augmented decrease in cell growth.

Apoptosis Analysis^[2]

Cell Line:	FaDu cells
Concentration:	50 µM, 100 µM and 200 µM
Incubation Time:	12 hours
Result:	Increased the activity of caspase 3 in a time-dependent manner.

Western Blot Analysis^[2]

Cell Line:	FaDu cells
Concentration:	200 µM
Incubation Time:	24 hours
Result:	The observed activation of caspase 3 and PARP (p85) levels.

In Vivo

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Capsaicin suppresses the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3^[2].
Capsaicin (2 μg in 40 μL per mice, injected into the plantar surface of the left hind paw) induces pain-related behaviour in mice^[4].
Capsaicin (3-30 μg in 10 μL per rat, plantar injection) induces secondary mechanical hypersensitivity (SMH) (used clinically as a model to potentially predict neuropathic pain) in rats^[5].
Capsaicin (0-500 μg in 25 μL per rat, injected subcutaneously into the center of the right vibrissae pad) induces pain in the orofacial region or rats^[6].
In high dose, Capsaicin may should be adminstered under anesthesia condition^[7]^[8].
Capsaicin is more pungent than Dihydrocapsaicin (HY-N0361)^[9].
Note: The spicy taste is choking, please take precautions.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice (20-25 g; 8-10 weeks old) induced by Benzo(a)pyrene^[3]
Dosage:	10 mg/kg
Administration:	Intraperitoneal administration; once in a week; for 14 weeks
Result:	Inhibited the development of mice lung carcinogenesis.

Clinical Trial

Molecular Weight

305.41

Formula

C₁₈H₂₇NO₃

CAS No.

404-86-4

Appearance

Solid

Color

White to off-white

SMILES

CC(C)/C=C/CCCCC(NCC1=CC=C(O)C(OC)=C1)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (327.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 100 mg/mL (327.43 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2743 mL	16.3714 mL	32.7429 mL
5 mM	0.6549 mL	3.2743 mL	6.5486 mL
10 mM	0.3274 mL	1.6371 mL	3.2743 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: 20 mg/mL (65.49 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 20 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (200.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 3

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 4

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (278 KB) SDS (476 KB)

COA (243 KB) HNMR (253 KB) RP-HPLC (247 KB) LCMS (326 KB)

Handling Instructions (2659 KB)

References

[1]. McNamara FN, et al. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol. 2005 Mar;144(6):781-90. [Content Brief]

[2]. Shin YH, et al. The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules. 2016 Jun 25;21(7). [Content Brief]

[3]. Anandakumar P, et al. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Jun 6;17(2):254-259. [Content Brief]

[4]. Nah JJ, et al. Effect of ginsenosides, active components of ginseng, on capsaicin-induced pain-related behavior. Neuropharmacology. 2000 Aug 23;39(11):2180-4. [Content Brief]

[5]. Joshi SK, et al Comparison of antinociceptive actions of standard analgesics in attenuating capsaicin and nerve-injury-induced mechanical hypersensitivity. Neuroscience. 2006 Dec 1;143(2):587-96. [Content Brief]

[6]. Pelissier T, et al. The orofacial capsaicin test in rats: effects of different capsaicin concentrations and morphine. Pain. 2002 Mar;96(1-2):81-7. [Content Brief]

[7]. Matsuda H, et al. Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sci. 1999;65(2):PL27-32. [Content Brief]

[8]. Demirbilek S, et al. Small-dose capsaicin reduces systemic inflammatory responses in septic rats. Anesth Analg. 2004 Nov;99(5):1501-1507. [Content Brief]

[9]. Friedman JR, et al. Anticancer Activity of Natural and Synthetic Capsaicin Analogs. J Pharmacol Exp Ther. 2018 Mar;364(3):462-473. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	3.2743 mL	16.3714 mL	32.7429 mL	81.8572 mL
	5 mM	0.6549 mL	3.2743 mL	6.5486 mL	16.3714 mL
	10 mM	0.3274 mL	1.6371 mL	3.2743 mL	8.1857 mL
	15 mM	0.2183 mL	1.0914 mL	2.1829 mL	5.4571 mL
	20 mM	0.1637 mL	0.8186 mL	1.6371 mL	4.0929 mL
	25 mM	0.1310 mL	0.6549 mL	1.3097 mL	3.2743 mL
	30 mM	0.1091 mL	0.5457 mL	1.0914 mL	2.7286 mL
	40 mM	0.0819 mL	0.4093 mL	0.8186 mL	2.0464 mL
	50 mM	0.0655 mL	0.3274 mL	0.6549 mL	1.6371 mL
	60 mM	0.0546 mL	0.2729 mL	0.5457 mL	1.3643 mL
	80 mM	0.0409 mL	0.2046 mL	0.4093 mL	1.0232 mL
	100 mM	0.0327 mL	0.1637 mL	0.3274 mL	0.8186 mL

Capsaicin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Capsaicin (Synonyms: (E)-Capsaicin)

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Capsaicin Related Antibodies

78 Publications Citing Use of MCE Capsaicin

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View All TRP Channel Isoform Specific Products:

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