2. Metabolic Enzyme/Protease PI3K/Akt/mTOR NF-κB Immunology/Inflammation Apoptosis Epigenetics
  3. Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Caspase Interleukin Related MicroRNA
  4. Protectin D1

Protectin D1  (Synonyms: Neuroprotectin D1; NPD1)

製品番号: HY-130413 純度: 99.0%
COA 取扱説明書 Technical Support

Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders.

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Protectin D1

Protectin D1 構造式

CAS 番号 : 660430-03-5

容量 価格（税別） 在庫状況 数量
Solvent
10 μg (277.40 μM * 100 μL in Ethanol) USD 400 在庫あり
Solvent
50 μg (277.40 μM * 500 μL in Ethanol) USD 1280 在庫あり

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Protectin D1 関連抗体

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

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Human Endogenous Metabolite Microbial Metabolite

PI3K アイソフォーム固有の製品をすべて表示:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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HIF-1α HIF

Caspase アイソフォーム固有の製品をすべて表示:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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製品説明

Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders[1][2].

IC50 & Target

Human Endogenous Metabolite

 

IL-1β

 

体外実験

Protectin D1 (1 μM, 24h) exerts cardioprotective effects in primary neonatal rat cardiomyocytes by upregulating miRNA-210 expression and activating the PI3K/AKT signaling pathway[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Protectin D1 関連抗体

Real Time qPCR[3]

Cell Line: Primary neonatal rat cardiomyocytes
Concentration: 1 μM
Incubation Time: 24h
Result: Upregulated miRNA-210 expression.

Western Blot Analysis[3]

Cell Line: Primary neonatal rat cardiomyocytes
Concentration: 1 μM
Incubation Time: 24h
Result: Increased p-AKT and HIF-1α protein levels.
体内実験

Protectin D1 (0.5, 1 μM/kg/day, i.p., once daily for 3 days) improves cardiac function and reduced infarct size in I/R-induced AMI rat model by inhibiting oxidative stress and inflammation[3].
Protectin D1 (0.08 mg/kg, i.p., single dose) exerts anti-inflammatory effects in CLP-induced sepsis rat model by reducing ROS concentration, inhibiting NALP3 inflammasome activation, and decreasing pro-inflammatory cytokine levels[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: I/R-induced acute myocardial infarction (AMI) rat model, male Sprague Dawley rats (8 weeks old)[3]
Dosage: 0.5 μM/kg, 1 μM/kg
Administration: Intraperitoneal injection (i.p.), once daily for 3 days before surgery
Result: Significantly reduced I/R-induced heart rate (HR), improved left ventricular ejection fraction (EF%) and fractional shortening (FS%), and reduced myocardial infarction area.
Animal Model: Cecal ligation and puncture (CLP)-induced sepsis Wistar rat model (8 weeks old, 200 g)[4]
Dosage: 0.08 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose (12 hours before surgery)
Result: Significantly reduced ROS concentration in hepatocytes of CLP-induced rats, decreased NALP3, ASC, and Caspase-1 expression levels, and lowered serum IL-18 and IL-1β concentrations.
分子量

360.49

分子式

C22H32O4
CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C[C@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\C/C=C\CCC(O)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Solution, -20°C, 2 years
純度とドキュメンテーション

純度: 99.10%

COA (238 KB)

取扱説明書 (2659 KB)
参考文献
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Protectin D1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protectin D1660430-03-5Neuroprotectin D1 NPD1Protectin D 1Protectin D-1Neuroprotectin D 1Neuroprotectin D-1NPD1NPD 1NPD-1Endogenous MetabolitePI3KAktHIF/HIF Prolyl-HydroxylaseReactive Oxygen Species (ROS)CaspaseInterleukin RelatedMicroRNAPhosphoinositide 3-kinasePKBProtein kinase BHypoxia-inducible factorsHIFsHIF-PHILmiRNAneuroprotectin D1neural celldocosahexaenoic acidpro-resolvinganti-inflammatoryInhibitorinhibitorinhibit

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