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Results for "

Pde4+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Amyloid-β (2) Apoptosis (2) Autophagy (3) Bacterial (3) Biochemical Assay Reagents (1) Calcium Channel (4) CXCR (1) Dopamine Receptor (1) Drug Intermediate (2) Drug Metabolite (1) Endogenous Metabolite (2) Environmental Pollutants (1) Epigenetic Reader Domain (2) GABA Receptor (1) HIV (3) IFNAR (2) Influenza Virus (1) Interleukin Related (9) Isotope-Labeled Compounds (3) mAChR (2) Microphthalmia Associated Transcription Factor (MITF) (1) mTOR (1) NF-κB (2) p38 MAPK (1) Phosphodiesterase (PDE) (107) PKA (1) Platelet-activating Factor Receptor (PAFR) (1) Reference Standards (12) RSV (5) TNF Receptor (9) TRP Channel (1) Tyrosinase (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Infection (5) Inflammation/Immunology (87) Metabolic Disease (5) Neurological Disease (22)

By Targets:

Adrenergic Receptor (2)

Amyloid-β (2)

Apoptosis (2)

Autophagy (3)

Bacterial (3)

Biochemical Assay Reagents (1)

Calcium Channel (4)

CXCR (1)

Dopamine Receptor (1)

Drug Intermediate (2)

Drug Metabolite (1)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Epigenetic Reader Domain (2)

GABA Receptor (1)

HIV (3)

IFNAR (2)

Influenza Virus (1)

Interleukin Related (9)

Isotope-Labeled Compounds (3)

mAChR (2)

Microphthalmia Associated Transcription Factor (MITF) (1)

mTOR (1)

NF-κB (2)

p38 MAPK (1)

Phosphodiesterase (PDE) (107)

PKA (1)

Platelet-activating Factor Receptor (PAFR) (1)

Reference Standards (12)

RSV (5)

TNF Receptor (9)

TRP Channel (1)

Tyrosinase (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (2)

Infection (5)

Inflammation/Immunology (87)

Metabolic Disease (5)

Neurological Disease (22)

111

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15455

Roflumilast 10+ Cited Publications APTA-2217; BYK 20869; B9302-107	Phosphodiesterase (PDE) RSV	Inflammation/Immunology
Roflumilast (APTA-2217) is a selective *PDE4* inhibitor with IC₅₀s of 0.7, 0.9, 0.7, and 0.2 nM for *PDE4A1, PDE4A4, PDE4B1, and PDE4B2*, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.

HY-12887

Piclamilast RP 73401; RPR 73401	Phosphodiesterase (PDE)	Inflammation/Immunology Cancer
Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC₅₀ values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively ^[4].

HY-10469

GSK256066 1 Publications Verification	Phosphodiesterase (PDE)	Inflammation/Immunology
GSK256066 is a selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor, with an IC₅₀ of 3.2 pM for PDE4B. GSK256066 is developed for the research of chronic obstructive pulmonary disease .

HY-122942

Moracin M 4 Publications Verification	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy	Inflammation/Immunology
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent **phosphodiesterase-4 (PDE4)** inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

HY-145583

Mufemilast Hemay005	Phosphodiesterase (PDE)	Others Inflammation/Immunology
Mufemilast (Heymay005) is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 80-120 nM). Mufemilast modulates cytokines upregulated in Behςet’s syndrome (BS). Mufemilast displays a significant inhibitory effect on TNF-α, which is an important proinflammatory cytokine target in the disease process of psoriasis. Mufemilast can be studied in research for diseases such as rheumatoid arthritis, psoriasis and BS ^[4] .

HY-109085

Difamilast 3 Publications Verification OPA-15406	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology Cancer
Difamilast (OPA-15406) is a topical, selective and nonsteroidal **phosphodiesterase-4 (PDE4)** inhibitor with particularly efficient inhibition of subtype B (IC₅₀=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) .

HY-108974

Drotaverine hydrochloride	Phosphodiesterase (PDE) Calcium Channel	Neurological Disease
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.

HY-147263

Dovramilast CC-11050	Phosphodiesterase (PDE)	Infection Inflammation/Immunology
Dovramilast (CC-11050) is an orally active phosphodiesterase 4 *(PDE4)* inhibitor and can reduce the inflammatory response and improves Isoniazid (HY-B0329)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB) .

HY-100246

CI-1044 PD-189659	Phosphodiesterase (PDE)	Inflammation/Immunology
CI-1044 is an orally active *PDE4* inhibitor with IC₅₀s of 0.29, 0.08, 0.56, 0.09 μM for *PDE4A5, PDE4B2, PDE4C2* and *PDE4D3*, respectively.

HY-N2443

Tribuloside 1 Publications Verification	Phosphodiesterase (PDE) Bacterial PKA Tyrosinase TRP Channel Microphthalmia Associated Transcription Factor (MITF) Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Tribuloside is a flavonoid and *PDE4* inhibitor (IC₅₀: 6 μM). Tribuloside exhibits antibacterial and antioxidant activities, capable of scavenging DPPH free radicals. Tribuloside also promotes melanogenesis. Tribuloside can be used in the research of hypopigmentary diseases, sun protection, and inflammatory diseases such as acute lung injury .

HY-105092

Tetomilast OPC-6535	Phosphodiesterase (PDE)	Inflammation/Immunology
Tetomilast (OPC-6535) is a *PDE4* inhibitor with potential for the research of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD).

HY-117960

Orismilast LEO-32731	Phosphodiesterase (PDE)	Inflammation/Immunology
Orismilast (LEO-32731) is an orally active and selective *PDE4* inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants .

HY-B0392

(S)-(+)-Rolipram (+)-Rolipram; (S)-Rolipram	Phosphodiesterase (PDE) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
(S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC₅₀ of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells .

HY-15178

Oglemilast GRC 3886	Phosphodiesterase (PDE)	Inflammation/Immunology
Oglemilast (GRC 3886) is a potent and orally active **phosphodiesterase-4 (PDE4)** inhibitor with an IC₅₀ of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases .

HY-103050

ML-030 1 Publications Verification	Phosphodiesterase (PDE)	Inflammation/Immunology
ML-030 is a potent *PDE4* inhibitor, with IC₅₀ of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.

HY-108617

YM976	Phosphodiesterase (PDE)	Inflammation/Immunology
YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses .

HY-108622

Mesopram Daxalipram	Phosphodiesterase (PDE) Interleukin Related IFNAR	Inflammation/Immunology
Mesopram (Daxalipram) is an orally active phosphodiesterase (PDE) 4 inhibitor. Mesopram inhibits the synthesis of proinflammatory cytokines TNF-α and IFN-γ. Mesopram demonstrates efficacy in ameliorating Dextran sulfate sodium (DSS) (HY-116282C)-induced murine colitis. Mesopram can be used for the study of chronic inflammatory diseases .

HY-139178

KVA-D-88	Phosphodiesterase (PDE)	Neurological Disease
KVA-D-88 is a blood-brain barrier-permeable *PDE4* inhibitor with IC₅₀ values of 140 and 880 nM for *PDE4B* and *PDE4D, respectively. KVA-D-88 induces cAMP accumulation and inhibits* neuroactive substance-mediated hyperlocomotion, locomotor sensitization. KVA-D-88 can be used for the research of drug addiction .

HY-144683A

PF-07038124 hydrochloride	Phosphodiesterase (PDE)	Inflammation/Immunology
PF-07038124 hydrochloride is a *PDE4* inhibitor with an IC₅₀ of 0.5 nM for PDE4B2. PF-07038124 hydrochloride shows inhibitory activities against IL-13, IL4, and IFNγ (IC₅₀=125, 4.1, 1.06 nM, respectively). PF-07038124 hydrochloride can be used for research of atopic dermatitis and plaque psoriasis .

HY-14826

Tilivapram AVE8112	Phosphodiesterase (PDE)	Neurological Disease
Tilivapram (AVE8112) is an orally active *PDE4* inhibitor with procognitive effects. Tilivapram exhibits in vivo efficacy and improves processing speed and psychomotor speed. Oral administration of tilivapram may induce dose-related adverse reactions such as nausea and dizziness, but transdermal delivery enables slow, controlled elevation of plasma concentrations, thereby significantly reducing gastrointestinal discomfort and dizziness. Tilivapram is applicable to research related to neuropsychiatric disorders .

HY-12740

Lotamilast RVT-501; E6005	Phosphodiesterase (PDE)	Inflammation/Immunology
Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ of 2.8 nM.

HY-108047

MK-0873	Phosphodiesterase (PDE)	Metabolic Disease Inflammation/Immunology
MK-0873 is a selective phosphodiesterase-4 (PDE4) inhibitor. MK-0873 increases intracellular levels of cyclic adenosine phosphate (cAMP) by inhibiting the activity of the *PDE4* enzyme and subsequently activates protein kinase A (PKA). Activated PKA inhibits the activity of inflammatory cells and leads to direct relaxation of airway smooth muscle. MK-0873 can be used in studies of chronic obstructive pulmonary disease (COPD) .

HY-15179

Ronomilast Elbimilast; ELB353	Phosphodiesterase (PDE)	Inflammation/Immunology
Ronomilast (Elbimilast; ELB353) is an orally active phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ of 3 nM. Revamilast can be used for research to inflammation related diseases .

HY-11070

MK-0952	Phosphodiesterase (PDE)	Neurological Disease
MK-0952 is a selective and orally active *PDE4* inhibitor, with an IC₅₀ of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study .

HY-19830

AN3199	Phosphodiesterase (PDE)	Inflammation/Immunology
AN3199 is a *PDE4* inhibitor with an IC₅₀ of 94.5 nM. AN3199 can be used for the research of inflammation-associated diseases such as asthma and chronic obstructive pulmonary disease (COPD) .

HY-161772

(S)-Gebr32a	Phosphodiesterase (PDE)	Neurological Disease
(S)-Gebr32a is a potent *PDE4* inhibitor with IC₅₀ values of 19.5, 2.1 µM for PDE4 cat; PDE4D3, respectively .

HY-115383

Roflupram 1 Publications Verification	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
Roflupram is a selective, orally active and brain-penetrant *PDE4* inhibitor, with an IC₅₀ of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors .

HY-144683

PF-07038124	Phosphodiesterase (PDE)	Inflammation/Immunology
PF-07038124 is a *PDE4* inhibitor with an IC₅₀ of 0.5 nM for PDE4B2. PF-07038124 shows inhibitory activities against IL-13, IL4, and IFNγ (IC₅₀=125, 4.1, 1.06 nM, respectively). PF-07038124 can be used for research of atopic dermatitis and plaque psoriasis .

HY-117977

FCPR03	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
FCPR03 is a potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC₅₀ values of 60 nM, 31 nM and 47 nM for PDE4 catalytic domain, *PDE4B1* and *PDE4D7*, respectively. FCPR03 displays at least 2100-fold selectivity over other PDEs (PDE1-3 and PDE5-11). FCPR03 has anti-inflammatory, neuroprotective and antidepressant-like effects .

HY-105096

Arofylline LAS 31025	Phosphodiesterase (PDE)	Inflammation/Immunology
Arofylline is a *PDE4* inhibitor as a potential research for asthma.

HY-B0327A

Irsogladine maleate 3 Publications Verification Dicloguamine maleate; MN1695	mAChR Phosphodiesterase (PDE)	Inflammation/Immunology
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.

HY-W700638A

Benafentrine maleate AH 21-132	Platelet-activating Factor Receptor (PAFR) Phosphodiesterase (PDE)	Cancer
Benafentrine maleate is a platelet activating factor receptor (PAFR) antagonist and a *PDE 4* inhibitor .

HY-125251

D159153	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
D159153 is a highly selective phosphodiesterase 4 (PDE4) inhibitor. D159153 is promising for research of asthma, chronic obstructive pulmonary disease (COPD), and neuroinflammatory disorders .

HY-N2958

Braylin	Phosphodiesterase (PDE)	Inflammation/Immunology
Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases .

HY-151174

PDE4-IN-12	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE4-IN-12 is a potent pan-PDE4 inhibitor, with IC₅₀s of 3.5 and 15 nM for *PDE4* and PDE7, respectively (SI=2.71 and 4.27, respectively). PDE4-IN-12 shows well tolerated, can be used in study of inflammatory bowel diseases (IBDs) .

HY-15455S

Roflumilast-d4 1 Publications Verification APTA-2217-d₄; BYK 20869-d₄; B9302-107-d₄	Isotope-Labeled Compounds Phosphodiesterase (PDE) RSV	Inflammation/Immunology
Roflumilast-d₄ is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC₅₀s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells .

HY-131707

LEO 39652	Phosphodiesterase (PDE)	Inflammation/Immunology
LEO 39652 is a dual-soft *PDE4* inhibitor with IC₅₀s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for *PDE4A, PDE4B, PDE4C* and *PDE4D, respectively. LEO 39652 also inhibits* TNF-α with an IC₅₀ value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) .

HY-124582

NEO214 1 Publications Verification	Autophagy mTOR	Cancer
NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram (HY-16900) and perillyl alcohol (HY-N7000). It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma .

HY-U00410

PDE4 inhibitor intermediate 1	Drug Intermediate	Others
PDE4 inhibitor intermediate 1 is an intermediate for PDE4 inhibitor synthesis.

HY-100118

BW-A 78U	Phosphodiesterase (PDE)	Inflammation/Immunology
BW-A 78U is a *PDE4* inhibitor with an IC₅₀ of 3 μM.

HY-177077

Davalomilast	Phosphodiesterase (PDE)	Inflammation/Immunology
Davalomilast (Example 100) is an *PDE4* inhibitor with anti-inflammatory property. Davalomilast can be studied in research for autoimmune diseases and dermatology research .

HY-19390

KW-4490	Phosphodiesterase (PDE)	Inflammation/Immunology
KW-4490 is a selective phosphodiesterase 4 (PDE4) inhibitor. KW-4490 can be used for the researches of inflammation and immunology, such as asthma .

HY-106245

HT-0712	Phosphodiesterase (PDE)	Neurological Disease
HT-0712 is a Phosphodiesterase Type 4 (PDE4) inhibitor. HT-0712 enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia .

HY-103024

ICI-63197	Environmental Pollutants Phosphodiesterase (PDE)	Neurological Disease
ICI-63197 is a phosphodiesterase 3 (PDE3) and *PDE4* inhibitor with K_i values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects .

HY-19672

Lirimilast BAY 19-8004	Phosphodiesterase (PDE)	Inflammation/Immunology
Lirimilast (BAY 19-8004) is a potent, selective and orally active **phosphodiesterase-4 (PDE4)** inhibitor with an IC₅₀ value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties .

HY-108623

Atizoram CP-80,633	Phosphodiesterase (PDE)	Inflammation/Immunology
Atizoram (CP-80,633) is an orally active phosphodiesterase type 4 (PDE4) inhibitor. Atizoram blocks cAMP degradation, thereby increasing intracellular and plasma cAMP levels. Atizoram inhibits TNFα release. Atizoram can be used in research related to acute respiratory distress syndrome .

HY-106044

Etazolate SQ 64442	Phosphodiesterase (PDE) GABA Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Etazolate (SQ 64442) is a α-secretase activator, selective *PDE4* inhibitor, selective GABA_A receptor modulator. Etazolate reduces IL-1β levels Etazolate exerts a dose-dependent anti-inflammatory and anti-œdematous effect accompanied by lasting memory improvement. Etazolate produces an antidepressant-like effect .

HY-109085R

Difamilast (Standard) OPA-15406 (Standard)	Reference Standards Phosphodiesterase (PDE)	Inflammation/Immunology
Difamilast (Standard) is the analytical standard of Difamilast. This product is intended for research and analytical applications. Difamilast (OPA-15406) is a topical, selective and nonsteroidal **phosphodiesterase-4 (PDE4)** inhibitor with particularly efficient inhibition of subtype B (IC₅₀=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) .

HY-15455R

Roflumilast (Standard) APTA-2217 (Standard); BYK 20869 (Standard); B9302-107 (Standard)	Reference Standards Phosphodiesterase (PDE) RSV	Inflammation/Immunology
Roflumilast (Standard) is the analytical standard of Roflumilast. This product is intended for research and analytical applications. Roflumilast (APTA-2217) is a selective *PDE4* inhibitor with IC₅₀s of 0.7, 0.9, 0.7, and 0.2 nM for *PDE4A1, PDEA4, PDEB1, and PDEB2*, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.

HY-W002463

3-Chlorophenyl boronic acid	Biochemical Assay Reagents	Others
3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .

Cat. No.	Product Name	Type

HY-W002463

3-Chlorophenyl boronic acid

Biochemical Assay Reagents

3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122942

Moracin M 4 Publications Verification	Classification of Application Fields Phenols Polyphenols Plants Moraceae Endogenous metabolite Inflammation/Immunology Disease Research Fields Morus alba Linn. Source Classification	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent **phosphodiesterase-4 (PDE4)** inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

HY-N2443

Tribuloside 1 Publications Verification	Tribulus terrester Linn. Flavonols Flavonoids Zygophyllaceae Phenols Polyphenols Plants Source Classification	Phosphodiesterase (PDE) Bacterial PKA Tyrosinase TRP Channel Microphthalmia Associated Transcription Factor (MITF) Interleukin Related
Tribuloside is a flavonoid and *PDE4* inhibitor (IC₅₀: 6 μM). Tribuloside exhibits antibacterial and antioxidant activities, capable of scavenging DPPH free radicals. Tribuloside also promotes melanogenesis. Tribuloside can be used in the research of hypopigmentary diseases, sun protection, and inflammatory diseases such as acute lung injury .

HY-N2958

Braylin	Structural Classification Rutaceae Coumarins Phenylpropanoids Plants Zanthoxylum tingoassuiba A.St.-Hil. Source Classification	Phosphodiesterase (PDE)
Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases .

HY-N3945R

Glaucine (Standard) O,O-Dimethylisoboldine (Standard); S-(+)-Glaucine (Standard); NSC 34396 (Standard)	Alkaloids Structural Classification other families Plants Isoquinoline Alkaloids Glaucium flavum Papaveraceae Source Classification	Reference Standards Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

HY-122942R

Moracin M (Standard)	Structural Classification Phenols Polyphenols Plants Moraceae Endogenous metabolite Morus alba Linn. Source Classification	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy Reference Standards
Moracin M (Standard) is the analytical standard of Moracin M. This product is intended for research and analytical applications. Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

Cat. No.	Product Name	Chemical Structure

HY-15455S

Roflumilast-d4 1 Publications Verification
Roflumilast-d₄ is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC₅₀s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells .

HY-108974S

Drotaverine-d10 hydrochloride

Drotaverine-d₁₀ (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects .

HY-15455S2

Roflumilast-d3
Roflumilast-d₃ is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.

HY-15455S1

Roflumilast-d4 N-Oxide
Roflumilast-d₄ N-Oxide is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC₅₀s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells .

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Pde4+Inhibitors

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